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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) - It is an effort to remove guns from dangerous people and an aggressive strategy by the City Attorney's office to implement a law that has been in place since 2016. Since the beginning of the year, the City Attorney’s office obtained 25 gun restraining orders, affecting teenagers to senior citizens.  “I think we have opened people's eyes to the availability of a tool that works,” said City Attorney Mara Elliott. “I think we all recognize that there are some people that should not have a gun or access to a gun.” It's a push to use a law Elliott said is underutilized. Now, she's training law enforcement to use it more.  These civil restraining orders prohibit someone from having a gun or ammunition. Law enforcement or close family members can request it if they're afraid someone will hurt themselves or others. A temporary order is issued until a hearing for a permanent one takes place. “It's not the city attorney or the police department making the determination... ultimately it's somebody that's got no horse in the race... a judge,” Elliott said.  This law came after a 2014 murder spree near Santa Barbara. Elliot Rodger stabbed three young men to death, then shot and killed three others. His family reported mental health concerns before the shooting.  “In the past, we had to wait for a tragedy. We don't have to wait anymore,” Mara Elliott said.  The City Attorney's office represents law enforcement in court.  Those with these restraining orders range in age from 19 to 81. All were men, except one. About a quarter involved were either current or former military. A City Attorney spokesperson said these numbers do not include minors that were connected to school shooting threats.  Team 10 spoke to one man who received a restraining order against him. He agreed to talk to 10News if he was not identified. According to the man, a fight with his wife was the catalyst for the restraining order. He claimed that he did not threaten his wife. “No, we never had a violent thing. Just words,” the man said.  It was a different story in the court petition. It said his wife was afraid and that the 81-year-old threatened “to shoot her” and the neighbor. His son, according to documents, was worried his parents were losing their sanity. It also showed he was arrested several years ago for domestic violence, but the charges were dropped. Still, he called the restraining order against him unfair. “I think every case is different. It depends on people you’re dealing with,” he said, calling himself a safe gun owner.  That man’s guns are at the San Diego Police Department. Under this law, guns are surrendered to law enforcement. An individual could also store them or sell them to a licensed firearms dealer. A permanent restraining order lasts a year. It expires unless someone seeks an extension. “We’ve done a lot to try and calm the nerves of those concerned about their Second Amendment rights,” Elliott said.  “Conceptually, the idea of taking firearms from criminals or people that are mentally unfit is something we stand behind,” said Michael Schwartz with the San Diego County Gun Owners PAC.  However, he still had concerns after meeting with the City Attorney. “If they've already broken the law, then we can take firearms from criminals or people that are mentally unfit. If they haven't broken the law, then why are we taking firearms from them?” Schwartz asked. He is also concerned about the potential for abuse of this law. The City Attorney's office said orders are issued when it’s not clear when or if a person will be charged or someone hasn't been convicted yet and the public needs protection. “I'm hoping that it makes people feel safer and it saves lives and I'm convinced we've done that,” Elliott said.  Elliott said it is still too early to determine any kind of trend of those served with a restraining order. There is a proposal right now to expand this law, allowing co-workers and school employees to request these types of restraining orders. That is heading to the Senate.     4173

SAN DIEGO (KGTV) -- Los Angeles County health officials are scrambling to prevent the spread of hepatitis A after three people became infected with the potentially deadly virus while in San Diego two months ago.In a motion filed by Los Angeles County's Fifth District Supervisor Kathryn Barger, she is asking the Dept. of Public Health to provide a report within 14 days on current efforts to stop an outbreak and a plan for response should one occur."At this time Public Health does not consider there to be a hepatitis A outbreak in Los Angeles County, however it is important that the County proactively educate the community on ways to prevent hepatitis A infection, and have a response plan in the event that the County does see an increase in hepatitis A cases," Barger said in her prevention plan.Citing public health officials, Barger says that the three people who acquired the infection had been in San Diego in mid-July.READ: Most hand sanitizers will not kill Hepatitis A?San Diego County health officials are in the midst of an hepatitis A epidemic with the first cases reported early this year. The virus is known to have sickened at least 421 people and killed 16 in San Diego County.The outbreak started with the homeless and drug using population, according to health officials.Now it has spread to the general population, with nearly 50 documented cases of people becoming sick, who have no ties to homeless or drug users, said the San Diego County Public Health Department.READ:?City opens bathrooms for homeless during hep A crisisCrews are power-washing sidewalks with a bleach solution in East Village downtown.Last week, San Diego county health officials warned customers of a Pacific Beach restaurant that they may have been exposed to a person with hepatitis A on several specific dates and times.San Diego County health officials confirmed the patient worked at World Famous Restaurant while infected. READ: Statement from World Famous RestaurantHepatitis A varies in severity, with mild cases lasting two weeks or less and in more severe cases lasting four to seven weeks or longer. Some individuals, especially children, may not develop jaundice or any symptom at all. However, even mildly ill people can still be highly infectious and should consult a physician, according to County Public Health Officer Dr. Wilma Wooten.Someone with hepatitis can be contagious to others before they develop symptoms, according to the HHSA.READ:?How can you tell if you have hepatitis A? 2569

SAN DIEGO (KGTV) -- Major decisions that could boost - or deal a real blow - to Republican candidates running for state offices about to be made in San Diego.It's because the California G.O.P. Convention kicks off Friday at the Sheraton Harbor Island. About 1,000 Republican delegates will be voting on a variety of endorsements for this year's ballot.G.O.P. gubernatorial candidates like Travis Allen and John Cox will attend, hoping to earn enough delegate votes for the party's endorsement for this year's election.The party is focussed only on state offices and initiatives - such as repealing the gas tax, said Cynthia Bryant, the state party's executive director.This is San Diego's second major political convention leading up to the June primary. The Democrats held their statewide convention here in February - with a who's who of national politicians.It was also the site of major news when the party declined to endorse Sen. Dianne Feinstein in her bid for re-election.The big difference for Republicans is that the party will not be taking up major federal issues like gun rights and immigration, Bryant said. The state party also won't be adopting a platform. Instead, Republicans will be focussing on the big decisions in the state - like repealing the recent 12 cent per gallon gas tax hike.They'll also be endorsing candidates for Governor, Lt. Governor, and attorney general. Still, Thad Kousser, who chairs the political science department at UC San Diego, says a lot of the decisions made could shape whether the Republicans can recruit new members. "Is this going to be a red meat crowd that really responds only to the visceral issues of immigrations? Or is it going to be a more strategic party that responds to issues that could help Republicans expand their base?" Kousser said. There are some closely watched congressional elections in San Diego County, including who will replace Republican Congressman Darrell Issa in the 49th district, and whether G.O.P Rep. Duncan Hunter can defend his seat in the 50th. Those endorsements could come later on. The convention runs through Sunday. 2157

SAN DIEGO (KGTV) - Loved ones gathered at Sunset Cliffs Friday to remember a high school student who died after jumping from 20 feet up, and drowning.10News learned the 15-year-old Anthony Womack and some friends skipped school to spend time at Sunset Cliffs on Wednesday.His friends told San Diego Lifeguards that the teen jumped into the water but immediately started to panic. The friends said they were unaware that Womack did not know how to swim.Friday night more than 100 people gathered to remember and mourn his loss."It was amazing seeing him every single day, seeing how happy he was walking to class," student Christian Perez said."I was walking to PE and heard someone say Anthony's drowning, and I ran up to them and said what happened and they said Anthony, Anthony's dead. Right when I heard that my whole body just froze, I had no words to say, I just started bursting out tears," he said.As the news spread, Christian said everyone was stunned, "the whole school was quiet, walking through, all the friends, it felt empty not having him there."Anthony's Grandma spoke with friends who were at the cliffs the day he died, giving her closure knowing exactly what happened. She also said it was only the second time he ever ditched school."He passed but he's still here, he's in all their hearts, their eyes and their minds, they all know him," Anthony's uncle, Garney Crews, said.At the vigil Crews brought the students together on the cliff, where Anthony jumped, "they had all their heads down, they were mourning , we don't want that. Anthony wouldn't want that."Instead he worked to spread the light his nephew shone, "hopefully it changes their heart and they become happy and they learn from it and they strive from it and they grow from it and when they pass this point at sunset cliffs, it's not just another place where water hits the rock, it's the place where their friend was taken to a higher level."Saturday there will be a car wash to fund-raise for Anthony's funeral, at the Church of God of Prophecy from 8 a.m. to 1 p.m. 2062

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