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SAN DIEGO (KGTV) - Anyone touched by Alzheimer's knows how painful the disease is. "It's affected my family. It's affected most families. It's such a prevalent disease. As people get older, it becomes quite likely this will become an issue," said Paul Aisen, director of USC's Alzheimer's Therapeutic Research Clinic (ACTC).Aisen's team began their research in San Diego many years ago and teamed up with USC about four years ago. He's spent over 30 years trying to solve Alzheimer's mysteries and is leading the upcoming clinical trial.Aisen says the large-scale study is the culmination of decades of work from scientists worldwide."Our focus lately has been trying to alter the disease, prevent it, or significantly slow its progression. How should we do that? We think attacking amyloid early is the most promising approach," said Aisen. Researchers believe sticky amyloid deposits, which form on the brain later in life, start the Alzheimer's process. Aging, genetics, and lifestyle factors can all contribute to amyloid build-up.The worldwide clinical trial aims to target amyloid. A drug called BAN2401 will be delivered intravenously, designed to bind to the sticky amyloid. The binding neutralizes beta amyloid and helps "tag" it, so the immune system can recognize it and clear it from the brain. A previous phase 2 study showed that BAN2401 removes brain amyloid and possibly slows cognitive decline.They're seeking participants over 50 who are not yet showing symptoms of Alzheimer's but do have elevated amounts of amyloid on their brain. Researchers can determine that through a PET scan or spinal tap. "We think that the most promising approach of all is to take a vigorous attack on amyloid while the brain is still functioning normally. And we can see amyloid in people many years before they develop the symptoms of Alzheimer's."Investigators hope that by treating a patient with BAN2401 very early in the disease, before symptoms occur, it will significantly slow disease progression. "If we're successful, it will have a huge impact on human health," said Aisen. There will be 100 sites worldwide for the study, including major cities like San Diego and Los Angeles. Study participants will receive treatment for four years, given either the drug or a placebo. Results are expected in seven years, Aisen says. If you or a loved one wants to participate, learn more here.Screening will officially begin in May. 2438

SAN DIEGO (KGTV) -- As hospitals in San Diego County receive vaccines from Pfizer and Moderna, a new concern is surfacing in the United Kingdom.A new COVID variant is reportedly infecting people rapidly and may be 70% more contagious than COVID-19. The new variant reportedly caused over 60% of infections in London this month alone.But there is good news, according to UC San Diego infectious disease expert Dr. Robert Schooley."It doesn't seem to be any more difficult to neutralize and should be responsive to the vaccines we're using,” Schooley told ABC 10News.RELATED: Britain hit with several travel bans over new coronavirus strainEven though there's no evidence yet of the new variant being deadlier than COVID-19, many European countries aren't taking any chances. Some countries have canceled inbound flights from England."The one caveat is if this virus accelerates an epidemic and more people are infected around you, your chance of getting infected will be greater with new and old strains, and so this vaccine will have to work harder, and we'll have to get more people vaccinated to have same level of population protection,” Schooley said.While the U.S. has yet to announce travel bans involving the UK specifically, Schooley said restrictions would certainly help the spread of any virus amid a global pandemic. 1336

SAN DIEGO (KGTV) -- As Santa Ana winds move out of the region, a freeze warning was issued for portions of San Diego County.The National Weather Service issued a freeze warning for the county's valleys and deserts from midnight through 10 a.m. Friday. Overnight temperatures dropped into the low 30s, with a few areas seeing temperatures in the mid- to upper 20s.The warning will affect cities including Escondido, El Cajon, San Marcos, La Mesa, Santee, and Poway.RELATED: Winter returns to Southern California mountains 528

SAN DIEGO (KGTV) – At least 10 people were arrested during demonstrations in downtown San Diego Wednesday night that were sparked by the grand jury decision in the Breonna Taylor case.ABC 10News learned there were initially two separate protests planned in the downtown area. Eventually, the two groups joined together.Protesters marched through downtown chanting and holding signs demanding justice for Taylor. The demonstration made its way to San Diego Police Department headquarters on Broadway.Shortly after 10 p.m., SDPD tweeted that there were acts of violence and vandalism and declared the protest outside headquarters “an unlawful assembly.”According to the tweet, the crowd was ordered to disperse or face arrest. In response to acts of violence & vandalism, the protest in front of the SDPD Headquarters building (1401 Broadway) has now been declared an unlawful assembly.Demonstrators are ordered to immediately disperse. If you do not do so you may be arrested. pic.twitter.com/coUlOTVZ6p— San Diego Police Department (@SanDiegoPD) September 24, 2020 ABC 10News confirmed with police that at least 10 people were taken into custody during the protest, but officials did not disclose what charges the arrestees face.Taylor, a 26-year-old emergency medical worker, was shot and killed by Louisville police officers during a botched drug raid on her home in March. The warrant used to search her home was connected to a suspect who did not live there, and no drugs were found inside.A grand jury in Louisville on Wednesday decided that no officers will face charges for Taylor's death.Prosecutors argued the two officers who fired at Taylor were justified in using force to protect themselves after they were shot at by Taylor's boyfriend.The officer who fired the fatal shot and another officer who fired his weapon at Taylor face no charges, but former Louisville Metro Police Department Detective Brett Hankison was indicted with three counts of wanton endangerment for firing shots that went through Taylor's apartment and into an adjoining unit.City News Service contributed to this report 2118

SAN DIEGO (KGTV) – Chick-fil-A participating locations will be hosting Military Appreciation Night Wednesday night.The popular chicken chain will be offering a free entrée and activities for all members of the military and their families.Activities at the Chula Vista restaurant on Olympic Parkway include a bounce house, crafts with Home Depot, a game truck, face-painting and a photo booth.The restaurant will be hosting several vendors offering raffle prizes including a barbeque grill, a big-screen TV, gift cards and 25 vouchers for a year’s worth of free Chick-fil-A.    604