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The US Food and Drug Administration approved Janssen Pharmaceuticals Inc.'s esketamine on Tuesday for treatment-resistant depression; the drug is the chemical cousin of ketamine, the powerful anesthetic that has been used illegally as the club drug Special K.It will be sold as Spravato. More specifically, it's for patients who have tried at least two other medications without success, and it should be taken with an oral antidepressant."There has been a longstanding need for additional effective treatments for treatment-resistant depression, a serious and life-threatening condition," Dr. Tiffany Farchione, acting director of the Division of Psychiatry Products at the FDA's Center for Drug Evaluation and Research, said in a 745

Three unprovoked shark attacks in the last three weeks has caused concern along the Carolina coast, especially after an 8-year-old boy was attacked on Sunday. An unnamed 8-year-old suffered puncture wounds on the leg, 230

The Transportation Security Administration released tips on Thursday to help travelers traverse through security and make it to their destination on time during the busy Thanksgiving holiday. The TSA said it expects to screen 26.8 million air passengers and crew members from Nov. 22 through Dec. 2, a 4 percent increase over 2018. Here are 10 tips the TSA wants travelers to know:Get to the airport early—two hours prior to a domestic flight and three hours before an international flight. Only a turkey gets to the airport in the last minute during the Thanksgiving travel period. Don’t be a turkey!Know which foods can travel in your carry-on bag. Pies, cakes, stuffing mix, casseroles, are all good in a carry-on bag because they are solid food items.Know which foods should go into a checked bag. Gravy, cranberry sauce, wine, jam, preserves, should all go into a checked bag. Why? They are not solids. Basically if you can spill it, spray it, spread it, pump it or pour it, (say that three times fast) then it’s not a solid and should be packed in a checked bag.Wear slip-on shoes. Shoe laces and zip-up boots take extra time to remove and put back on. Wearing slip-ons just saves you time. But admittedly, it’s fun to watch someone else hop around on one foot as they try to remove a boot.Place your electronic carving knife (or your non-electric knife) in your checked bag. Should be a no-brainer, wouldn’t you think?Pack smart. Don’t bring along any prohibited items. If you are not sure if an item should go in a carry-on bag, checked bag, either or neither, don’t be shy, just tweet your question to @AskTSA or ask via Facebook Messenger.Download the free MyTSA app. The best thing about it is the “Can I bring” feature. Type in an item and it lets you know immediately if you should pack it in a checked or carry-on bag. It also can let you know if there is an airport delay and whether TSA Precheck lanes are available. Super helpful. And if you get bored during the holiday, you can use it to play a game with your relatives by asking them to guess if an item should be packed in a checked or carry-on bag and using the app to provide the correct answer.Use your time in the checkpoint line wisely. It’s the perfect time to take items out of your pockets and place them in your carry-on bag and to get your ID and boarding pass ready to hand to the TSA officer.Enroll in TSA Precheck--if not before Thanksgiving, then before your next trip. It allows you to leave on your shoes, lightweight jacket and belt when you go through the checkpoint. Plus, you can leave your electronics and your one-quart-size liquids bag in your carry-on bag instead of removing it at the checkpoint. It’s like driving in the fast lane.Pay attention to the guidance that the TSA officers are providing at the checkpoint. They may be directing you to a shorter line or guiding you around someone who is moving slowly. And they may be giving you some advice that will lessen the likelihood that you’ll need a pat-down.Justin Boggs is a writer for the E.W. Scripps National Desk. 3081

There has been a small increase in vaccine exemption rates among kindergarteners in the United States, according to a new report from the US Centers for Disease Control and Prevention.The finding, published in the CDC's 232

The US State Department has updated its travel advisories for 35 countries with a new indicator to highlight the risk of kidnapping and hostage taking.The announcement comes days after American tourist Kimberly Sue Endicott and her tour guide were rescued by security forces after being abducted in Uganda's Queen Elizabeth National Park.High-threat countries including Uganda will now be labeled with a "K" in order to "communicate more clearly to US citizens the risks of kidnapping and hostage taking by criminal and terrorist actors around the world," the department said Tuesday.Travel advisories the following countries have been updated to include the "K" indicator: Afghanistan, Algeria, Angola, Bangladesh, Burkina Faso, Cameroon, Central African Republic, Colombia, Democratic Republic of the Congo, Ethiopia, Haiti, Iran, Iraq, Kenya, Lebanon, Libya, Malaysia, Mali, Mexico, Niger, Nigeria, Pakistan, Papua New Guinea, Philippines, Russian Federation, Somalia, South Sudan, Sudan, Syria, Trinidad and Tobago, Turkey, Uganda, Ukraine (in Russian-controlled eastern Ukraine), Venezuela, and Yemen.Endicott and her guide were abducted at gunpoint while on a game drive last week, according to the Ugandan Tourism Board and Ugandan police.Four other people were taken at the same time, but they were freed while Endicott and her driver were taken from the park, officials said.The State Department said it was aware of the rescue."We are aware of reports that a US citizen hostage was recovered on April 7 by Ugandan security officials," a State Department spokesperson told CNN. "Privacy considerations prevent us from commenting further at this time." 1672