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SAN DIEGO (KGTV) — Researchers at UC San Diego Health are now looking for volunteers to participate in a COVID-19 clinical trial, starting locally next week.Oxford-AstraZeneca’s vaccine clinical trials will take place in 36 states across the country.“This is the second vaccine trial for the prevention of COVID-19, and like the first, it is a trial of 30,000 individuals nationally,” said Dr. Susan Little, a professor of Medicine and UCSD and the lead on this trial.Little said UCSD researchers hope to enroll about 1,600 people in eight weeks to participate in the trial.“Eighteen or older, in generally good health, but with underlying conditions that put them at greater risk for COVID-19,” she said. “Or people with increased risk of acquiring COVID-19 because of their professions or where they live.”Little said a bus would act as a mobile vaccine clinic. The bus will stop in parking lots in communities that have been historically underrepresented in medical research or disproportionately affected by COVID-19.“We’re going to focus on communities most impacted, the South Bay, East County, underserved communities and communities that have been hardest hit by COVID-19 those with the highest rate of infection in the community,” she said. “It’s a series of two vaccines, a month apart, people will be prescreened over the phone, and then they’ll be vaccinated on day one and day 29. Then they’ll be followed for two years thereafter.”In Phase 1 and Phase 2 clinical trials, Little said the vaccine proved to be safe.“We know that it’s safe in the sense that it causes local tenderness, some mild fatigue headache. Side effects went away in about one week,” she said. “This will be placebo-controlled, so I won’t know, and the participants won’t know whether they got a vaccine or placebo.”She said for every one person who gets the placebo, two people will get the vaccine.If people develop COVID-19 symptoms during the trial, two other mobile wellness clinics will be available for treatment.“Anybody who develops symptoms that are worrisome to COVID, we will come see them in our wellness vehicles and test them for COVID. The most important thing is to assess the sort of severity of their symptoms and determine whether they’ve developed COVID while on the study,” she said.Little said the goal is that there might be enough data to see if this vaccine is effective in six to nine months.“We have two ways out of this pandemic, treatment, and vaccines,” she said. “Our hope is through vaccine efforts like this, we won’t just find one vaccine that works, but we might find several.”Anyone interested in volunteering can learn more by clicking here, or calling 619-742-0433. 2696

SAN DIEGO (KGTV) – Restrictions in California due to the COVID-19 pandemic have forced many youth sports teams around San Diego County to head to other states to play games.Under current pandemic-related guidelines, youth sports teams in California have been limited to practices only. The restrictions have been frustrating for many parents and coaches.Anthony Lococo, a coach for San Diego travel baseball organization King Kong Baseball, said, "At this point, we thought we would be in a position where there would be a plan in place to get us back to playing. If I told you five or six months ago that we'd have to travel to play, I would have told you no way. I thought we would have had a plan in place by now."Rene Miramontes, director of coaching for local-based Crusaders Soccer, feels traveling to play in other states was bound to happen."In youth sports in particular, with no recourse, you have to start looking for options,” Miramontes said.Those options include heading east to places like Yuma, Arizona. In fact, the San Diego Union-Tribune reported about a recent baseball tournament in Yuma which featured 51 teams. Of those teams, 49 were from California."I gave it a couple months, with the plan that if we weren't open by October or November, we would have to look into going to other states," said Lococo.Since pandemic regulations went into effect in March, many youth tournaments in San Diego have been canceled, costing the city a lot of money. According to the U-T report, the amount of money lost could be in the hundreds of millions of dollars.Now, San Diego families are heading to places like Arizona and Utah for tournaments, and of course, absorbing the costs that come with it.Lococo plans to take his King Kong Baseball teams to Arizona in the next month."As a family, you are renting a hotel for one to two nights, depending on how long the tournament is. Price-wise, you're probably talking five, six, seven hundred dollars per family,” said Lococo.Of course, the most important thing is the safety of the young athletes. Which in turn brings about the discussion of whether playing games transmits the disease."In my opinion, there are no indicators that show us that," said Miramontes. "I see no reason why we are still in the no contact state." 2291

SAN DIEGO (KGTV) — Researchers at the University of California, San Francisco are working on a spray designed to block the novel coronavirus from hijacking cells in the body, like a biological mask or internal personal protective equipment.They’re doing it by borrowing a defense mechanism from an unlikely source: llamas.The team, led by UCSF graduate student Michael Schoof, engineered a synthetic molecule based on one found in a llama’s immune system that acts like an antibody but is one-tenth the size.Human antibody treatments, known as convalescent plasma, require a transfusion in a hospital setting. But this smaller molecule, called a nanobody, can be easily self-administered via an inhaler or nasal spray and rapidly manufactured using yeast, Schoof said.The scientists named their product AeroNabs. They say it could be an inexpensive intervention for treating and preventing COVID-19 while the world waits for a vaccine.“We don't know how effective vaccines will be. We don't know how long it will take to rapidly deploy them, so we envision this product as hopefully a bridge until there is widespread, effective vaccination,” Schoof said.Once a vaccine is available, AeroNabs could offer protection for individuals who are unable to be inoculated for health reasons, he said, or an early treatment option.The team is in talks with commercial partners and hopes to begin clinical trials soon.In the 1980s, Belgian scientists discovered that about half of the antibodies in camels, llamas and alpacas are shaped differently than the antibodies found in other mammals, including humans. Researchers later learned they could use a fragment of these oddly shaped camelid antibodies to bind to antigens.Those fragments are called nanobodies.Currently, there is only one FDA-approved drug that uses nanobodies. Caplacizumab was approved last year to treat a rare blood disorder.The team at UCSF sifted through billions of nanobodies to find one that binded best to the spike proteins on the coronavirus, then engineered it to stick even better.The coronavirus uses its spikes to enter cells and replicate; the spikes are essentially the pathogen’s key into the body. By coating the spikes with nanobodies or antibodies, the viral key no longer fits into the body’s receptors and the virus can’t get in.“This works in the lab. It needs to be translated into the clinic,” said Schoof.The team at UCSF still needs to figure out the best delivery method, whether it is a nebulizer, an inhaler or a nasal spray. 2524

SAN DIEGO (KGTV) -- San Diego Gas and Electric and the city of San Diego are in a disagreement that could be worth up to 0 million.The controversy is over San Diego's Pure Water project, which would turn sewage into high treated drinking water. The city's goal is to have a third of its water supply be reclaimed water by 2035. To accomplish that, the city plans to build a billion pipeline to pump sewage from the Morena area to the North City Water Reclamation Plant on the edge of Miramar.On Thursday, the City Council voted 5-4 to approve about .1 billion for the project. But completing the pipeline would require SDG&E to remove its gas and electric lines. The city says SDG&E usually does that on its own dime, but this time - the utility says it will not spend the money. The City Attorney's office is now involved.The council voted 8-1 to authorize million this fiscal year, but is retaining its legal rights to recover the money. The city may have to spend another million next fiscal year to complete the project.In a statement, SDG&E says it supports the project but is working to protect its ratepayers."Our goals are to assist the City with their plans and ensure our customers, especially those outside City limits who will not benefit from the project, are not unfairly burdened with utility relocation costs," the statement said. The city hopes to begin advertising for construction for the pipeline next month.   1491

SAN DIEGO (KGTV) – San Diego County is working to make it easier for San Diegans to get flu shots, which health officials say is especially important this year because of the coronavirus pandemic.On Thursday, local leaders kicked off efforts to promote flu vaccinations. Over the course of the next few weeks, they will be hosting pop-up clinics across the county where people can get free flu shots.The pop-up clinics are designed for those who don’t have insurance or those who can’t get the vaccine from their health care provider or pharmacy.Valentina Christiansen came to one of the clinics to get flu shots for her family. She said, “I think it’s great because I tried to go through our health plan and that’s over a month out, and we wanted to get it sooner. We heard about the opportunity and we’re excited to be able to do that.”Dr. Denise Foster, chief nursing officer for the county, said getting the flu vaccine can also help in the battle against the coronavirus. Keeping flu patients out of the hospital frees up beds and resources for those fighting COVID-19.“The flu vaccine can prevent the flu and prevent people from seeking health care services that might be needed right now connected to the pandemic,” Foster said.Foster added there are more people that have gotten the flu vaccine this year in comparison to this same time last year. They’re hoping this trend continues.Free flu shot clinics will take place on specific dates at these locations:Saturday, Oct. 24 at South Public Health Center, 690 Oxford Street, Chula VistaTuesday, Oct. 27 at North Coastal Public Health Center, 3609 Ocean Ranch Blvd, OceansideWednesday, Oct. 28 at Central Public Health Center VIP Trailer, 3177A Oceanview BlvdThursday, Oct. 29 at East Public Health Center, 367 N. Magnolia Avenue, El CajonTuesday, November 3 at North Inland Public Health Center, 640 W. Mission Ave #2, Escondido 1896

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