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Dr. Anthony Fauci delivered more good news regarding a potential coronavirus vaccine, indicating some Americans could begin getting vaccinated by the end of this month.During an interview with CNN’s Wolf Blitzer, Fauci, the director of the National Institute of Allergy and Infectious Diseases National Institute of Allergy and Infectious Diseases, said it’s possible a vaccine could begin reaching some Americans by the end of the month, but was confident some would begin getting vaccinated by the end of the year.Fauci’s declaration came on the same day Pfizer said that its Phase 3 vaccine candidate was showing an effectiveness of over 90%. Fauci said the announcement was promising, but a few more questions need to be addressed before it is given approval. Fauci said that things like the vaccine’s durability and effect on the elderly are among concerns that still need to be tackled.“We may have doses that we’re able to give to people by the end of November, beginning of December,” Fauci told CNN’s Blitzer. “Now you have to go through the hoops of making sure all of the I’s are dotted and the T’s are crossed about the safety and regulatory aspects of it, but we would be giving vaccine, very likely, by the end of this year. That is good news.”Last month, the FDA put into place guidelines on approving a vaccine, which was more restrictive than what the White House had hoped for. The FDA noted that a vaccine candidate must be at least 50% effective. Vaccine candidates should include a median follow-up duration of at least two months after completion of the full vaccination regimen to help provide adequate information to assess a vaccine’s risk-benefit.“In addition to outlining our expectations for vaccine sponsors, we also hope the agency's guidance on COVID-19 vaccines helps the public understand our science-based decision-making process that assures vaccine quality, safety and efficacy for any vaccine that is authorized or approved,” Peter Marks, M.D., Ph.D., director of the FDA's Center for Biologics Evaluation and Research, said.While it is possible some will begin getting vaccinated in the coming weeks or months, questions remain on how soon a majority of the country will have the opportunity to become vaccinated. The first Americans slated to become vaccinated will be health care workers and people with a high risk of coronavirus complications, such as the elderly and those living in assisted living facilities, according to an NPR report.Given that Pfizer’s vaccine candidate is showing a high level of effectiveness, Fauci called the development “extraordinary.”"We know there's light at the end of the tunnel, but that doesn't mean that we're going to give up the important public health measures that we continually still have to do every single day,” Fauci said.While there is urgency for both public health and economic reasons for a vaccine, some experts have expressed concern over the speed of a vaccine and whether the expedited timeline is long enough to demonstrate efficacy.Even though a vaccine could be ready by year’s end, trials will be expected to continue for over a year to monitor for possible side effects.According to the FDA, a typical Phase 3 trial would take one to three years.“NIH is committed to supporting several Phase 3 vaccine trials to increase the odds that one or more will be effective in preventing COVID-19 and put us on the road to recovery from this devastating pandemic,” said NIH Director Francis S. Collins, M.D., Ph.D. “We also know that preventing this disease could require multiple vaccines and we’re investing in those that we believe have the greatest potential for success.”Pfizer said based on current projections, it expects to produce globally up to 50 million vaccine doses in 2020 and up to 1.3 billion doses in 2021. 3823

DULZURA, Calif. (KGTV) -- New details emerged Monday in a warrant released after a man is accused of poisoning his wife.A search warrant revealed that the woman had been sick for months and had no idea what was going on with her.According to the warrant, the young mother began to feel sick in September, then started feeling better before her condition worsened in January.She suffered hair loss, no longer had the strength to walk or open a door and had to be helped around by family members and her extremities even became like dead weights, according to the warrant.RELATED: East San Diego County man suspected of poisoning his wife with Thallium The warrant goes on to say that she suffered major loss of use of her extremities and was near death.Doctors determined that she received thallium poisoning by oral ingestion. Thallium is a chemical element used in rat poison and ant killers.Investigators determined that the poisoning could have only been done by someone with personal access to the food and drinks she consumed.According to the warrant, her husband Race Remington Uto, 27, had the most access to commit the crimes.Investigators searched the couple’s home in Dulzura and confiscated laptops, a coffee blender, four cups and other electronics.The warrant also shows that Race had an affair while he was deployed in the Navy and that the couple had gone through counseling.Race told detectives he has no idea how his wife came into contact with the poison. She also said she had no idea who would want to hurt her.The warrant shows the victim thought she may have been exposed to the poison while working in an old school building. 1661

Dominic Raab has resigned as Brexit Secretary. In a statement he said he “cannot in good conscience support the terms proposed for our deal with the EU.”The pound has plunged on the back of Raab’s surprise resignation. Last night, after the United Kingdom and European Union agreed on the text of a Brexit withdrawal agreement, British Chancellor Phillip Hammond held a conference call with business leaders to convince them the draft agreement was the way forward. But Raab’s resignation has sent the business community back into uncertainty with the threat of a no deal scenario resurfacing.When addressing the House Thursday morning, British Prime Minister Theresa May said Wednesday's deal is not the final Brexit deal. May said that delivering Brexit involves difficult choices. She said she respected the views of those who resigned and thanked them.“There is no deal which delivers the Brexit the British people voted for without this insurance policy,” May said, referring to the Irish border backstop agreement that has infuriated some Brexiters.Two Cabinet ministers, two junior ministers and a parliamentary aide resigned on Thursday morning, just hours after May won approval from her Cabinet for the draft Brexit deal.   1296

Devastated to hear of today’s shooting in Texas. We pray for the victims and their families. Our team at Apple Cielo Vista and the entire El Paso community are close to our hearts, and we’re grateful to the first responders on the scene.— Tim Cook (@tim_cook) August 3, 2019 288

Drug kingpin Joaquin "El Chapo" Guzman will be examined by a psychologist next week after his lawyer argued the conditions of his confinement in New York have taken a toll on his memory and mental state.US District Judge Brian Cogan in Brooklyn granted permission Wednesday for Guzman to be evaluated following a defense motion alleging that solitary confinement in a cold, small cell at a federal lockup in Manhattan had the drug lord forgetting names and places and suffering from hallucinations, paranoia and depression."I'm not alleging that he's not competent" to stand trial, Guzman's new attorney, Eduardo Balarezo, told reporters after a pretrial hearing."I'm alleging that the conditions that he's been under for the last nine months or so are affecting his memory, affecting his ability to relay information that I need as his lawyer to defend him."Guzman, who is commonly known by his nickname "El Chapo," which loosely translates as "shorty," was extradited to the United States from Mexico in January and immediately brought to the federal courthouse in Brooklyn for his arraignment on a 17-count indictment.His trial in Brooklyn is set to begin in April 2018.Wednesday's hearingThe 60-year-old defendant, dressed in a dark blue prison uniform, entered the courtroom for Wednesday's brief hearing smiling and waving at his former beauty queen wife, Emma Coronel, and their six-year-old twin daughters. He followed the proceedings through an interpreter.Federal prosecutors have turned over 90,000 pages of discovery -- most detailing drug shipments and seizures -- but Balarezo said he took issue with government plans to wait until two weeks before trial to share the testimony of alleged collaborators."Every one of them is going to be here trying to reduce their sentence," the attorney said outside court.The head of the Sinaloa Cartel, Guzman is named in a sweeping 17-count indictment alleging that from 1989 to 2014 he led a continuing criminal enterprise responsible for importing and distributing massive amounts of narcotics and conspiring to murder rivals who posed a threat, according to federal prosecutors.Guzman is also charged with firearm violations related to drug trafficking and money laundering connected to the smuggling from the United States to Mexico of more than billion in cash from narcotics sales.Guzman has pleaded not guilty to the charges, which carry a minimum sentence of life in prison. Federal prosecutors also intend to seek a billion criminal forfeiture order against him.Years as a fugitiveGuzman has been confined to a solitary windowless cell, removed from the general population in a facility that is part of the federal Bureau of Prisons.Chasing 'El Chapo': Prison breaks, hideaways and life on the lamBefore hiring Balarezo, Guzman last summer retained attorney Jeffrey Lichtman, who represented John Gotti Jr. in a 2005 federal trial which ended with the dismissal of murder conspiracy charges.Prior to Lichtman, the man accused of running one of the world's largest drug trafficking organizations was represented by court-appointed public defenders.After more than a dozen years on the run after escaping from prison in 2001 -- allegedly by hiding in a laundry cart -- Guzman was again arrested in 2014.However, a year later he escaped through a hole in his cell block that led to a tunnel nearly a mile long. In 2016 Mexican security forces rearrested Guzman in Sinaloa.Mexican drug cartels take in between and billion annually from US drug sales, and a 2015 Congressional Research Service report estimates at least 80,000 people have been killed due to organized-crime-related incidents since 2006.RELATED: Mexico arrests top Sinaloa cartel heroin trafficker 3743