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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086
A locked-down pandemic-struck world cut its carbon dioxide emissions this year by 7%, the biggest drop ever, new preliminary figures show.The Global Carbon Project, an authoritative group of dozens of international scientists who track emissions, calculated that the world will have put 37 billion U.S. tons (34 billion metric tons) of carbon dioxide in the air in 2020. That’s down from 40.1 billion US tons (36.4 billion metric tons) in 2019, according a study published Thursday in the journal Earth System Science Data.Scientists say this drop is chiefly because people are staying home, traveling less by car and plane, and that emissions are expected to jump back up after the pandemic ends. Ground transportation makes up about one-fifth of emissions of carbon dioxide, the chief man-made heat-trapping gas.“Of course, lockdown is absolutely not the way to tackle climate change,” said study co-author Corinne LeQuere, a climate scientist at the University of East Anglia.The same group of scientists months ago predicted emission drops of 4% to 7%, depending on the progression of COVID-19. A second coronavirus wave and continued travel reductions pushed the decrease to 7%, LeQuere said.Emissions dropped 12% in the United States and 11% in Europe, but only 1.7% in China. That’s because China had an earlier lockdown with less of a second wave. Also China’s emissions are more industrial based than other countries and its industry was less affected than transportation, LeQuere said.The calculations — based on reports detailing energy use, industrial production and daily mobility counts — were praised as accurate by outside scientists.Even with the drop in 2020, the world on average put 1,185 tons (1,075 metric tons) of carbon dioxide into the air every second.Final figures for 2019 published in the same study show that from 2018 to 2019 emissions of the main man-made heat-trapping gas increased only 0.1%, much smaller than annual jumps of around 3% a decade or two ago. Even with emissions expected to rise after the pandemic, scientists are wondering if 2019 be the peak of carbon pollution, LeQuere said.“We are certainly very close to an emissions peak, if we can keep the global community together,” said United Nations Development Director Achim Steiner.Chris Field, director of the Stanford Woods Institute for the Environment, thinks emissions will increase after the pandemic, but said “I am optimistic that we have, as a society learned some lessons that may help decrease emissions in the future.”“For example,” he added, “as people get good at telecommuting a couple of days a week or realize they don’t need quite so many business trips, we might see behavior-related future emissions decreases.”___Follow AP’s climate coverage at https://www.apnews.com/Climate___Follow Seth Borenstein on Twitter at @borenbears .___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3048

A former Nazi labor camp guard who has been living in the United States for decades has finally been deported to Germany after years of diplomatic wrangling, the White House announced on Tuesday.Jakiw Palij, who worked as a guard at the Trawniki Labor Camp, in what was then German-occupied Poland, had been living out his post-war years in Queens, New York City.Palij, 95, was born in what was then-Poland and now Ukraine, and immigrated to the US in 1949, becoming a citizen in 1957. The former Nazi guard lied to US immigration officials about his role in World War II, saying he worked on a farm and in a factory, the White House said in a statement.In 2001, Palij admitted to US Department of Justice officials that he had in fact trained and worked at the Trawniki Labor Camp in 1943. On November 3, 1943, around 6,000 Jewish prisoners at the camp were shot to death in one of the single largest massacres of the Holocaust, according to the White House statement. 977
A growing group of Republicans want Attorney General Jeff Sessions to be the party's choice in the Alabama Senate race, but ethics experts say Sessions either would have to have to leave the Department of Justice or continually disavow campaigns to put him in the seat if he wants to run for the office and avoid legal trouble.This week Senate Majority Leader Mitch McConnell of Kentucky and Senate Majority Whip John Cornyn of Texas both said they would support Sessions as a write-in candidate over Republican candidate Roy Moore, who has been accused of pursuing sexual relationships with teenagers when he was in his 30s.Moore denies the allegations, and says he has no plans leave the race. And Sessions has not indicated that he's planning to run for his old seat.But ethics experts say that even if Sessions does not himself campaign to be a write-in candidate in the race, he could have an "affirmative duty" to disavow campaigns to put him in the Senate while he's still the attorney general. If he remains silent, he could be in violation of the Hatch Act, a 1939 law restricting the ability of most federal employees to engage in political campaign activities.Walter Shaub, a former director of the US Office of Government Ethics who's now at the nonprofit Campaign Legal Center, told CNN that the federal Office of Special Counsel has issued an advisory opinion on write-in candidates, which specifies:"(S)uch a candidacy is permissible only if spontaneous and accomplished without an employee's knowledge. You acknowledge that you have heard rumors of a write-in effort to elect you to the school board. It would be a violation of the Act if you encouraged this effort or remained silent. The Act imposes on you an affirmative duty to disavow this effort through public announcements and other appropriate means." It remains to be seen whether the OSC considers the comments by McConnell and Cornyn as imposing an "affirmative duty.""There's a question as to whether it's a write-in campaign or a stray comment from one guy," Shaub said following McConnell's comments. "If McConnell keeps talking about it, he's going to create an affirmative duty."Larry Noble, a senior director at the Campaign Legal Center who's a CNN contributor, said Republicans such as McConnell are "putting (Sessions) in a very difficult position" by even suggesting he be a write-in candidate."We are close to the line of his having to disavow," Noble added.For Sessions to be eligible as a write-in candidate, Noble said, he would have to "affirmatively disavow" any campaign or resign from office to avoid violating the Hatch Act.Sessions would likely be asked about his support for the write-in candidacy frequently until the December 12 election. Questions could also be raised about whether he was having private conversations about the effort with the state party and the Republican National Committee, which also would violate the Hatch Act.In response to a request for comment, Sarah Isgur Flores, director of public affairs for the Department of Justice, said, "Our ethics officials will need to evaluate precisely what has been said by others and then review what, if any, affirmative obligations we may have."Samuel Bagenstos, a University of Michigan Law School professor who specializes in constitutional litigation, noted that a few previous attorneys general -- including Dick Thornburgh and Robert Kennedy -- have campaigned for Senate seats, but neither were floated as write-in candidates."It's extremely suboptimal for an attorney general, who is supposed to have some insulation from electoral politics, to be actively running for a political office," Bagenstos said, adding, "And of course there would be lots of possible recusal questions."Aside from ethical considerations, running as a write-in candidate would be a long shot even if Sessions resigned.Few candidates have won Senate seats via write-in campaigns. Sen. Lisa Murkowski, R-Alaska, won her seat that way in 2010, but prior to her election the last person to do it was Strom Thurmond in 1954.However unlikely, a Sessions victory would serve two purposes for the GOP: The party would retain the seat, and Sessions would leave the DOJ after months of public criticism by President Donald Trump over his decision to recuse himself from the Russia investigation and not to prosecute Trump's political enemies. 4412
A Los Angeles coroner says rapper Mac Miller died from a mixture of some pretty heavy drugs. The rapper died two months ago and his autopsy shows the combination of fentanyl, cocaine and alcohol is what killed him.Miller was 26 years old and a native of Pittsburgh, Pennsylvania. His real name is Malcolm James McCormick and he had a public struggle with drug abuse, USA Today reports. 415
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