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Could the no-calorie sweetener you rely on to replace sugar in your diet actually cause weight gain instead of the weight loss you were expecting?The answer may be yes, according to a new study."Artificial sweeteners are not risk-free," said Brian Hoffmann, assistant professor in the Department of Biomedical Engineering at the Medical College of Wisconsin and Marquette University, and a lead author of the study. "They are a very controversial topic when it comes to health and nutrition ... but they're so prevalent in society that I think we owe it to ourselves to try and figure out what's actually going on."Hoffmann presented his new research Sunday at the annual?Experimental Biology meeting in San Diego. Relying on rats and human cell cultures, his team identified a number of pathways linking artificial sweeteners with metabolic changes at the genetic level that could lead to diabetes and obesity. Specifically, the researchers found that three weeks of exposure to aspartame and acesulfame potassium -- two artificial sweeteners frequently combined in products such as Equal -- altered the expression of certain genes responsible for lipid metabolism in the cells of both rats and humans."Aspartame had some significant changes, and one of those was an increase in lipids in the bloodstream and a decrease in a biomolecule that is involved in clearing (lipids) from the bloodstream. And we saw the exact same thing with the acesulfame potassium," Hoffmann said."We then took those particular sweeteners and put them on endothelial cells -- the cells that line the blood vessels and would be exposed to them in the body -- and we detected a marked dysfunction, suggesting why sweeteners and diet soda have been linked to potential cardiovascular problems," he added.What was perhaps most surprising, according to Hoffmann, was that these metabolic changes did not occur in the presence of natural sugars such as glucose and fructose. This suggests that artificial sweeteners could contribute to metabolic disorders such as diabetes and obesity by an entirely different mechanism than natural sugars, he said.Artificial sweeteners appear to contribute to metabolic disorders by altering the activity of certain genes responsible for the breakdown of macromolecules such as fats and proteins, Hoffmann said. This is different from normal sugars, which contribute to cardiovascular disease through insulin resistance and by damaging the cells lining the body's blood vessels."People are generally consuming non-nutritive sweeteners believing they are a 'healthy choice,' but this may not be true," said research scientist Meghan Azad of the University of Manitoba in Winnipeg, who was not involved in the new study."This is especially important given the widespread and increasing consumption of artificial sweeteners in the general population and the increasing use of artificial sweeteners in our food supply," said Azad, who has authored a paper that reviewed a number of studies on the potential downside of artificial sweeteners on weight and health.According to Azad, over 40% of adult Americans consume no-cal sweeteners on a daily basis, and studies that measure the sweeteners in blood and urine show that many people who report not using artificial sweeteners are unknowingly consuming them.It's the latest assault in the ongoing debate over artificial sweeteners and their impact on health -- a debate that began when one of our most popular foods, sugar, turned sour in terms of health. 3527
CLEVELAND — A mother in Shaker Heights, Ohio said her daughter was ridiculed after asking her cheerleading coaches for a larger uniform. Mother Lakessa Taylor claims the fat-shaming didn't end there.Laylonie Dowdell, 16, rejoined the cheerleading squad at Shaker Heights High School this fall, but after a summer off, her uniform was a little snug.Her mother told her to request a new, larger one and the teen said what happened next left her speechless."They basically refused to order me a uniform because they said it held my boobs down," Dowdell said.She not only complained that her top was extremely tight, she told an assistant coach her pants were too small as well."She replied, 'I wonder why? You're eating too much,' and insisted I run laps back and forth to the stop sign and back until my ride got there," said Dowdell.Dowdell said she didn't want to show her two coaches she was upset, so her coping mechanism was to always smile and giggle."You're supposed to be my coach, she's supposed to mentor me, uplift me, but you're putting me down," said Dowdell.In a video from an away game in Medina, Ohio you can see Dowdell having to pull her uniform down.After struggling with it at another game in Mentor, Ohio she said she was approached by the assistant cheerleading coach while holding a hot dog and a pop.Dowdell said the coach asked her: "What are you putting in your mouth now? Why are you eating that?"Dowdell's mom said the hurtful comments left her daughter broken."We train our children to fend off bad things from other children, but we don't train them to defend themselves against adults," Taylor said.Taylor said as soon as her daughter told her what was going on, she notified the principal."I complained to the school on Monday. Today is Friday. I haven't heard anything from the school," said Taylor.While she hasn't heard anything from the school district, Taylor got a chance to talk with the assistant coach."She told me herself, 'Well, Laylonie was laughing and joking and so I didn't think there was anything wrong with what I said. Laylonie talks to me about her weight sometimes, so it was OK for me to say those things to her,' " said Taylor.Since coming forward and sharing her story, both coaches in question have resigned. WEWS was told the head coach planned to do so anyway at the end of football season."This is not the only complaint. We're talking about several. I've talked to four parents in the last 24 hours," said Taylor.In light of these allegations, the district is praising the head coach for her 23 years of service, calling her a devoted coach, a mentor and a "valuable member" of the athletic department."It's disturbing that the school is commending this lady for all that she has done," said Taylor.The district refused WEWS's requests for an on-camera interview, but a spokesperson said they take complaints of this nature very seriously.In the meantime, Dowdell said for the first time ever she's having issues with her body image."I know I'm pretty, I know I'm beautiful. But, when I look in the mirror I'm not as skinny as the next girl, or I can lose a few," said Dowdell.In a statement, the district said that despite these resignations, the investigation into these complaints will continue. 3290

CNN reporter Jim Acosta's press credentials for the White House were stripped "until further notice," after Press Secretary Sarah Sanders accused him of "placing his hands on a young woman."Sanders tweeted out a video of Acosta at a news conference questioning President Trump, but some sources are saying the video is doctored.The news conference aired nationally before the video was released, and many people saw the original incident. They say the video appears to have cut out Acosta saying "pardon me, ma'am" to a White House intern who was reaching to take away a microphone.In the allegedly doctored video, it appears Acosta's arm movement of pushing away the intern was sped up. 695
CORONADO, Calif. (KGTV) -- A man's peaceful visit to Coronado's Dog Beach turned into one of major concern when he saw boat debris lining the shore.Todd Tremelling feared the dogs and marine life would eat the materials. Tremelling was at Dog Beach over the weekend when he saw a boat stuck along the fence that separates the public part of the beach from Naval Air Station North Island.The boat is one of about a dozen abandoned boats that have washed ashore due to storms. On Saturday, he saw a crew from the base removing the boat with a backhoe."They were using the bucket to beat it into a million pieces, or probably 10 million," said Tremelling, who regularly takes his two dogs to the beach. When he returned on Sunday, he saw the shoreline was lined with boat debris, including wood paneling, fiber glass, and foam that lined the hull. Tremelling filled a bucket with the debris before an animal could eat it. "They need to do a better job," said Tremelling, of the removal. Sandy Duchac, a spokeswoman for Naval Air Station North Island, said crews follow strict procedures when removing the boats. "At the end of the day we do everything we can to remove the debris from the boats that people allow to come ashore," she said. "There's very little we can do about teh debris that ends up on the Coronado side."Duchac said the Navy has removed about a dozen boats that washed ashore after storms in the last year. It's almost impossible to identify the owners because the boats are often abandoned and the ownership information has been removed.It costs taxpayers about ,000 to remove each boat. 1646
CLEVELAND — Twenty-seven men from Northeast Ohio have been arrested after they allegedly expressed interest in engaging in sexual activity with undercover officers those men believed to be minors during an operation led by the Ohio Internet Crimes Against Children (ICAC) Task Force called “Operation Moving Target,” according to Cuyahoga County Prosecutor Mike O’Malley.Initial charges were filed against the individuals include attempted unlawful sexual conduct with a minor, disseminating matter harmful to juveniles, importuning, and possessing criminal tools.The arrested individuals include:Adam Davis, 41, PainesvilleRajwant Singh, 44, Mayfield HeightsGermaine Truett, 38, ClevelandJason Johnson, 37, ClevelandRonel Washington, 24, Garfield HeightsHector Pietri, 29, ClevelandKyle Vansteenburg, 28, ClevelandRaphael Robinson, 26, ClevelandCorey Huber, 32, ElyriaMichael Labondano, 30, LyndhurstNicholas Cook, 38, Bedford HeightsChazz Johnson-Hawks, 22, SolonIan Rensel, 43, BedfordJerry Harris, 35, WestlakeCarson Strnisa, 21, Seven HillsJustin Cowger, 22, ClevelandKim Koran, 61, ClevelandNathan Troup, 39, New Castle, PA (Registered Sex Offender in the State of Pennsylvania)Abed Aldur, 45, ParmaArturo Martinez, 47, University HeightsPhillip Jones, 30, StreetsboroKeith Kozak, 41, BrooklynPedro Correa Jr., 42, ClevelandRyan Dempsey, 37, AshtabulaJohnathan Smith, 34, ClevelandRobert Spisak, 45, Broadview HeightsJason Schmucker, 37, CantonThe four-day operation started on Aug. 24 and ended on Aug. 27. The arrested individuals, ranging in age from 21 to 61 years old, allegedly engaged in sexually explicit online conversations with undercover officers posing as children on popular social media applications, according to a news release.The county prosecutor alleges that the men expressed interest in engaging in sexual activity with the purported children and/or disseminated images of their genitals during these online conversations.After the conversations, the individuals traveled to a pre-arranged location, which was a vacant house in Cuyahoga County, to engage in sexual activity, with the undercover agents posing as children.All were arrested and taken to the Cuyahoga County Jail. Several of those arrested were in possession of firearms, condoms, lubricant, sex toys and drugs.Each case will be presented to a Cuyahoga County grand jury.“As we have seen the number of Cybertips dramatically increase this year, it is clear that online predators remain a serious threat to our children,” said O’Malley in a release. “Hopefully the success of yet another operation serves as a stern warning to offenders that you will be found, you will be arrested, and you will be prosecuted."This article was written by Kaylyn Hlavaty for WEWS. 2762
来源:资阳报