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With over 160 vaccines in development, the race to defeat COVID-19 continues.A California company hopes to deliver its vaccine to your mailbox; one that is pain-free and doesn't require a needle and syringe."One of the things I wanted to do was make vaccines more patient-friendly, so they don't hurt and you're not afraid to take them," said Dr. Dan Henderson, a virologist and the CEO of Verndari, Inc.The biopharmaceutical company is based in Napa, California. Dr. Henderson originally came to the wine country to retire but stepped back into the lab during the Ebola crisis. He says some adults avoid vaccines because of a fear of needles, so Verndari set out to do something different. They created the VaxiPatch, a single-dose vaccination kit that uses a dermal patch with a metal microneedle array to deliver vaccines. Once applied, the person wears the patch like a Band-Aid for five minutes. The vaccine uses the COVID-19 "spike" protein that enables the virus to infect human cells and works to enhance a person's immune person.Unlike traditional vaccines, the patch doesn't need to be refrigerated, which Henderson says would make it easier and cheaper to send to developing countries. The company initially set out to make a flu vaccine but switched gears during the pandemic; they continue to adapt to the world's changing needs. "Now, for the First World, it's a shelter-in-place vaccine," said Henderson.They're working with the FDA to see if it could be mailed to your home. The vaccine would leave a temporary blue mark so the patient could take a photo and send it to their health care provider as proof of vaccination. In collaboration with the UC Davis, they've begun clinical trials in animals. Dr. Henderson says so far the results are promising.Other researchers are also working on getting a patch like this on people's arms.Scientists at the University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center have created a fingertip-sized skin patch that is also showing promising results in animal testing. Verndari hopes to test its vaccine in humans in the fall, and if all goes well, it could be made available to the public early next year. Dr. Henderson believes they could manufacture about 20 million doses a month. "It would mean a lot because it's important to me to make a contribution and a contribution like that, to me, is priceless." 2408

YOSEMITE NATIONAL PARK, Calif. (AP) — A Romanian tourist has died in a fall near a waterfall in Yosemite National Park in California.Authorities say 21-year-old Lucian Miu was scrambling on wet rocks below Bridalveil Fall on Wednesday when he fell about 20 feet. He died at a hospital.The Fresno Bee says two other people were injured in separate falls in the park this week.One had hiked to a viewing platform below Bridalveil Fall on Monday and then slipped while climbing up a boulder field toward a pool at the base.The other slipped off a boulder at Lower Yosemite Fall and fell into a creek Thursday, becoming trapped underwater between rocks before managing to escape. 683

— down 9 percent since its peak of 72 percent in 1960, according to the U.S. Census Bureau.Love remains the top reason given for why folks are getting married. That's above things such as the need for companionship, having kids, and financial stability, 255

Clifford said he believes that the FDA "cries wolf" too often when it comes to warning about the effects of kratom."For instance, two years ago the FDA claimed 44 deaths (caused by kratom)," he said. "The American Kratom Association was able to obtain the toxicology reports ... they discovered that the people who died had other drugs in their systems, that no one had died from kratom alone."Clifford said he believes the FDA is conflicted by pharmaceutical industry, and pharmaceutical lobbyists don't want the kratom to prosper at the industry's expense. But also said that the kratom industry has been asking the FDA to implement manufacturing guidelines for years in the hopes of keeping customers safe and healthy."We don't want anyone to get sick from Salmonella or E-coli," he said. 797

for their roles in a conspiracy to bring large amounts of heroin, fentanyl, cocaine, crack cocaine and marijuana from California to the Cleveland area to sell.Teams of law enforcement officers hit the streets early Tuesday morning across Northeast Ohio.According to the indictment, the drugs were sent to Ohio from California via domestic shipping."At a time when a record number of our neighbors were dying from drug overdoses, this organization allegedly brought in large amounts of fentanyl, heroin and cocaine from California and sold it all over Northeast Ohio," U.S. Attorney Justin Herdman said. "Some members of the conspiracy used rifles and other firearms to protect their products while others laundered tens of thousands of dollars in drug money.""Illegal drug activity brings danger to our communities — it will not be tolerated," said FBI Special Agent in Charge Eric B. Smith. "Collaborative law enforcement efforts will continue to identify and disrupt drug trafficking organizations bringing violence to our streets."The case was investigated by the Northern Ohio Law Enforcement Task Force (NOLETF) and SouthEast Area Law Enforcement Narcotics Task Force, a collaboration of suburban northeast Ohio police departments.The NOLETF is a long-standing multi-agency task force comprised of investigators from the FBI, DEA, IRS , U.S. Coast Guard Investigative Service, and a dozen law enforcement agencies in northeast Ohio. The NOLETF is also one of the initial Ohio High Intensity Drug Trafficking Area (HIDTA) initiatives. HIDTA supports and helps coordinate numerous Ohio drug task forces in their efforts to eliminate or reduce drug trafficking in Ohio.Named in the 30-count indictment are: Brandon Fletcher, 35, of Warrensville Heights Edgar Arturo Sanchez, 27, of Paramount, CaliforniaStephon Carter, 34, of ClevelandDonnie Palmer, 34, of Cleveland Heights, OhioKevin Philmon, 37, of ClevelandWayne Nix, 27, of Warrensville Heights, OhioRobert Hawes, 46, of Bedford, OhioAntonn Melton, 37, of Maple Heights, OhioKevin Williams, 34, of Euclid, OhioRobert Pollard, 29, of Lithonia, GeorgiaFreddie Murphy, 33, of ClevelandEric Armstrong, 58, of South Euclid, OhioJamillMcDonald, 37, of Cleveland Heights, OhioSteven Bouyer, 52, of ClevelandDarcell Jackson, 32, of Euclid, OhioLonnie Jordan, 29, of Maple Heights, OhioDeWitt Chisholm, 38, of Warrensville Heights, OhioThis story was originally published by Tracy Carloss on 2443