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SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617

SAN DIEGO (KGTV) — Included in the new defense budget bill just passed by Congress is what some call the most sweeping military housing reforms in decades. However, San Diego military families are concerned that a loophole will allow the private companies that oversee the housing developments to continue ignoring what they call "slum" conditions.10News has been digging for months into the problems reported by residents at local communities run by Lincoln Military Housing, one of the biggest companies in the industry. Residents say they have been plagued by mold, which has caused illness, as well as rodent and insect infestations, and shoddy maintenance and repairs.RELATED: .7 million awarded to Housing Commission to house military veterans"Lincoln Military Housing doesn't do a very good job of maintaining the infrastructure of these homes," says resident Erika Bradley.Bradley says the recent storms have led to more problems with leaks and mold. She says around 50 families living in the Santo Terrace community in Tierrasanta were forced to leave their homes and move into hotels.The new deal agreed to by Congress include the framework of significant reforms, including a tenant bill of rights, a strict set of regulations for how complaints should be handled, and an arbitration process that leaves the final decision in the hand of base commanders, rather than the companies. RELATED: Marine Corps family wins lawsuit against Lincoln Military Housing, after kids sickened by moldHowever, the language in the bill appears to indicate that the companies will not be forced to sign on to the new processes, making them voluntary. While the military and Congress can use the failure to agree to the processes as grounds to decide not to renew the contract with a company, most of the housing companies have long-term deals in place. That means it's possible that it could be nearly 30 years before some of them would be forced to consider making changes."It's kind of something that looks really good on paper," Bradley says, "but how does it actually help us in our day to day lives?"10News asked if Lincoln plans to agree to the new procedures. A spokesperson responded that the company is reviewing the provisions passed by Congress. RELATED: Navy takes action on complaints of mold, rats in military housingIn a statement to 10News, she said "Lincoln Military Housing, along with our military partners, have instituted a series of reforms to improve service for military families. We will continue to work with our partners on ways we can continue to improve service and strengthen the program.” 10News also reached out to Congresswoman Susan Davis and Senator Dianne Feinstein, who have both worked on military housing issues. Neither was available for an interview. 2794

SAN DIEGO (KGTV) — It's a new season with new threads for the San Diego Padres.The Padres unveiled new home and away sets of uniforms sporting the team's classic brown colors during a fashion show-style event at Petco Park Saturday.Third baseman Manny Machado, first baseman Eric Hosmer, and shortstop Fernando Tatis Jr. were on hand to model the new look the Friars take into 2020. Two styles of the new uniforms featured a return to pinstripes, one on a white base reading "Padres" and the other on dark gray reading "San Diego." The third uniform was brown with gold "San Diego" across the chest and dark gray pants. 627

SAN DIEGO (KGTV) - It is Tax Day, and if you’re like most Californians, you’re probably wondering what happened to the nice refund you’re used to getting. Or worse, you owe the government this year. So how do you Make it in San Diego on Tax Day? We found an expert who can help.It's the worst sticker shock imaginable. You're used to a little something back from the government every year in the form of a refund, but suddenly you find yourself with a hefty bill. And the feds don't look kindly on late payments."I always tell people: if you owe money, the first step is don't panic," says Ariel Jurow-Kleiman an Assistant Professor of Law at the University of San Diego. Jurow-Kleiman should know. She's helped people in this situation many times before as a tax attorney and now teaches tax law at USD. Here's the problem."The Federal tax laws were changed in a way that will dramatically affect California residents," explains Professor Kleiman.And that's probably what hit you, too. Many itemized deductions you used to get were either tossed out or capped. "It used to be you could deduct all of your state income taxes," adds Jurow-Kleiman.Now those California income taxes are capped at ,000. And your house, the interest on the mortgage was capped too - double whammy. So, if you owe, here's the first step: do not put off filing. "Absolutely, it is so important to file your taxes on time even if you think you're going to owe," says Professor Kleiman, emphasizing the point. There are penalties for filing late: 5% of your tax liability and up to a maximum of 25%. So, let's say you owe 00 and didn't file for a month, that alone will cost you at least an extra . So, file right away, and pay what you can now."There is interest, it fluctuates, right now it's 6%. It compounds daily so every day, every week that you owe there is a little bit more interest that's added on," warns Jurow-Kleiman.That compound interest can accrue quickly but Professor Kleiman says there are options. You could file for an extension and pay the full amount later. Or you could work out an installment agreement but know some fees could be tacked on. In some cases, paying off your taxes with a credit card could be cheaper than the interest from the government."If you're considering owing money to the government versus owing money to a private lender,” adds Professor Kleiman, “It's very often better to borrow money from a private lender and pay your taxes."However, Professor Kleiman adds that’s not always the case. She advises avoiding payday lenders or someone who charges very high-interest rates. And there is help, especially for those with low incomes, the elderly and the disabled.We have provided links to the Volunteer Income Tax Assistance Program and the local Taxpayer Advocate. For local low income clinics you can call the University of San Diego LITC at (619) 260-7470 or Legal Aid Society of San Diego LITC at (877) 534-2524.Finally, make sure you don’t fall into this situation again next year by checking that you have the proper withholding in your paycheck. You can discuss that with your Human Resources representative at work or a tax expert. 3181

SAN DIEGO (KGTV) — Mardi Gras is right around the corner, which means San Diegans are getting ready to "laissez les bons temps rouler" (let the good times roll.)Several events this weekend will kick off the local festivities in San Diego. All of it culminating on March 5, known as "Fat Tuesday,"traditionally the last day of the Carnival season.Looking for Kings Cake as well? Try out this delicious recipe from San Diego Family Magazine!Here are some great events you won't want to miss out on:San Diego Mardi Gras Fat Tuesday Celebration When: March 1 - 2, March 5 Where: Gaslamp District Cost: Starts at Mardi Gras gets started early in San Diego's Gaslamp District with 20 parties over the weekend and then for one more night on Fat Tuesday. Tickets get guests access to more than 20 nightclubs, bars, and restaurants, an opening night and finale party, and food and drink specials around downtown.Gaslamp District Mardi Gras Big Easy Bites & Booze TourWhen: March 2Where: Gaslamp DistrictCost: Starting at Enjoy a taste of San Diego and Mardi Gras with 20 Mardi-Gras inspired plates, Carnival cocktails, an exclusive after party at a secret location, and more during the Gaslamp Mardi Grass Big Easy Bites and Booze Tour through downtown.2nd annual Blvd. Mardi Gras CrawlWhen: March 3Where: El Cajon Boulevard, North ParkCost: Tickets are free for - specialsA traveling party will take over North Park's El Cajon Boulevard, bringing guests across local breweries, bars, and restaurants for drink and food specials, led by the Euphoria Brass Band along the way! The final stop will be a party at the Lafayette Hotel for music, dancing, and the best-decorated “Mardi-Bra” contest.Mardi Gras 10K & 5KWhen: March 3Where: Rancho Bernardo Community ParkCost: - Celebrate Mardi Gras and enjoy a Carnival in the park in Rancho Bernardo at the inaugural Mardi Gras 10K & 5K. Hit the scenic trails around RB in colorful Mardi Gras gear and enjoy a finish line festival!Mardi Gras Party at House of BluesWhen: March 5Where: House of Blues San DiegoCost: No cover, open to publicHouse of Blues celebrate Mardi Gras with a party at its restaurant and Voodoo Room, featuring a special food and drink menu, circus and interactie entertainment, and live music by Madame Leroux & Krewe. 17th Annual Hillcrest Mardi GrasWhen: March 5Where: Hillcrest Pride FlagCost: - Hillcrest will host a neighborhood-wide party crawl through the area's best bars, clubs, and music venues. Themed party stops will greet guests with drink deals, collectible beads, giveaways, and live entertainment! 2613