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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) — Jalen McDaniels, San Diego State University basketball's sophomore forward, was accused of filming consensual sex acts with a classmate in 2016 without her knowledge and sharing it with friends, according to a civil lawsuit filed Wednesday in Washington.The civil suit alleges McDaniels recorded the intimate moments with an 18-year-old female student while they were both seniors at Federal Way High School near Tacoma, Wash.The lawsuit goes on to say while McDaniels later told the plaintiff about the unauthorized recordings and that he had shared it with his friends, she learned from other students that the video became widely circulated. When she confronted McDaniels, he explained he had gotten away with a similar incident involving another female student, according to the lawsuit.The plaintiff's attorney, Joan Mell, who filed the suit, wrote her client has suffered from several self-destructive behaviors as a result, including attempting suicide.SDSU is accused of wrongdoing in the lawsuit as well.Mell alleges in the lawsuit that SDSU was contacted by Washington police to provide them with McDaniels' phone number, but failed to do so. The suit says SDSU, instead, alerted former basketball coach Steve Fisher, who secured McDaniels a lawyer, and McDaniels refused to cooperate.The suit goes on to allege McDaniels' refusal to cooperate and, "that others concealed his wrongdoing prevented prompt criminal investigation and referral to the prosecutor's office for timely filing of criminal charges under Washington’s criminal offense of distribution of intimate images."In a statement, SDSU said there would be "no change in [McDaniels'] status at the university" at this time, after an investigation by Washington authorities resulted in no charges before McDaniels' enrollment at the school: 1837

SAN DIEGO (KGTV) -- Mayor Kevin Faulconer is among local leaders expected to leave for Mexico City Sunday morning. The trip, which includes Imperial Beach Mayor Serge Dedina, is meant to strengthen ties between the border. The mayors plan to discuss border infrastructure projects, pollution in the Tijuana River Valley and economic ties with leadership in Mexico. RELATED: Trump threatens to 'close' parts of US/Mexican border if Mexico doesn't immediately halt immigrationThe trip comes as President Trump said he would shut down the border with Mexico if the country doesn’t handle the wave of asylum seekers entering the U.S. The San Diego Regional Chamber of Commerce says shutting down the border would have severe consequences. “Our daily lives are effected by the border crossings and how long that takes. So we certainly wish that not to be something to be toyed with,” said Jason Wells, Executive Director of the San Ysidro Chamber of Commerce. The San Ysidro Port of Entry is the busiest land crossing in the U.S. with nearly 100,000 vehicles and pedestrians crossing every day. 1098

SAN DIEGO (KGTV) — In a scientific 10News/Union-Tribune poll, 500 adults were surveyed on their thoughts on the response to the coronavirus thus far.Adults were asked whether they trusted news about the virus coming from government officials and media, and if they've started to stockpile supplies in response.Overall, a majority of San Diegans surveyed are concerned about the virus, but many also believe the government is making it seem less dangerous while the media is making it seem more dangerous.Most San Diegans who participated also say they have not started to stockpile supplies like toilet paper and hand sanitizer in response.Here's a look at some of the survey's results:How concerned are you about the coronavirus?Extremely: 23 percentSomewhat: 38 percentOn The Fence: 14 percentNot Very Concerned: 19 percentNot At All Concerned: 6 percentNot Sure: 1 percentBased on what you know, do you believe each of the following is telling the truth about the coronavirus? Making the coronavirus seem more dangerous than it actually is? Or making the coronavirus seem less dangerous than it actually is?The World Health Organization, or WHO, in Switzerland:Telling The Truth: 48 percentMaking It Seem More Dangerous: 30 percentMaking It Seem Less Dangerous: 7 percentNot Sure: 15 percentThe US Centers for Disease Control and Prevention, or CDC, in Atlanta:Telling The Truth: 47 percentMaking It Seem More Dangerous: 29 percentMaking It Seem Less Dangerous: 12 percentNot Sure: 12 percentPresident Donald Trump: Telling The Truth: 22 percentMaking It Seem More Dangerous: 16 percentMaking It Seem Less Dangerous: 47 percentNot Sure: 15 percentState health officials:Telling The Truth: 39 percentMaking It Seem More Dangerous: 33 percentMaking It Seem Less Dangerous: 13 percentNot Sure: 16 percentGovernor Gavin Newsom:Telling The Truth: 29 percentMaking It Seem More Dangerous: 26 percentMaking It Seem Less Dangerous: 10 percentNot Sure: 35 percentNational news media:Telling The Truth: 22 percentMaking It Seem More Dangerous: 64 percentMaking It Seem Less Dangerous: 5 percentNot Sure: 9 percentDo you support or oppose the use of Marine Corp Air Station Miramar as a place to quarantine those who have or may have been exposed to the coronavirus?Support: 57 percentOppose: 22 percentNot Sure: 21 percentAs a result of the coronavirus, have you ... Bought extra hand sanitizer?Yes: 28 percentNo: 72 percentBought extra toilet paper?Yes: 16 percentNo: 84 percentBegun to stockpile non-perishable food items?Yes: 14 percentNo: 86 percent 2554

SAN DIEGO (KGTV) - It's been more than a month since the big ship fire in San Diego Bay.The flames are out but the boat is still there.It's become a sort of "morbid tourist attraction." Tourists and locals stopping to take photos of the charred Norton Sound bobbing up and down in the bay.RELATED: Multi-alarm fire erupts on fishing vessel docked in San Diego BayRestaurateur Melissa Moore was working just feet away when the ship mysteriously turned into a giant oven on Sept. 29. The smoke hung over Seaport Village sickening those nearby."As workers, we all started having headaches. We had to just leave," Moore recalled.Now it's early November and many are wondering why the boat is still parked in front of the Greek Islands Cafe - which Moore's family owns.RELATED: Questions remain after investigation into boat fire at San Diego HarborThe Port of San Diego told 10News they were working with the U.S. Coast Guard to move the ship as soon as possible. Contractors were disposing of chemicals on board.The Coast Guard cautioned there was no immediate leak or threat to the environment.Where did the ship come from?...10News learned the Norton Sound - which now has gaping holes in it - was originally owned by an American company in Seattle. It sailed into our bay in March.A San Diego shipping agent found it a place to dock. And then it was sold to a company in Mexico.Since the fire, a company employee has met with the Port and the Coast Guard at least once."I never did hear what was exactly in there," Moore said.No cargo was listed on the paperwork. San Diego Fire-Rescue said the cause of the fire was still under investigation, but there is currently no reason to suspect arson.So what now?...For now, the pier is locked off - which frustrates Moore."That is something people like to walk down," Moore said.RELATED: Mystery surrounds fishing boat that erupted in fire on San Diego BayStructural engineers must inspect it, according to the Coast Guard, and said the owner may not be able to afford to pay for the Norton Sound's removal.The Coast Guard is planning to use money from a special clean-up fund - paid for by a tax on oil refineries - to remove the ship. However, that may not happen for a few more weeks."The only positive thing is that people are still coming down here taking pictures.  (laughs)  other than that, they can take it away," Moore said. 2431

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