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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086

A former Playboy model who allegedly had a nine-month affair with President Donald Trump is suing the company that kept her original account from publication, The New York Times reported Tuesday.The Times said Karen McDougal is suing to be released from an agreement mandating her silence.The report would make McDougal the latest woman to take legal action over an agreement restricting her from speaking out about an alleged relationship with the President prior to his time in government. The White House has said Trump denies the affair.Shortly before the presidential election, the Wall Street Journal published a story saying American Media Inc., the company that owns The National Enquirer, paid 0,000 to McDougal, but did not run her story in a tabloid maneuver known as "catch and kill." The contract, according to the Journal, did not require the Enquirer to run the story and required McDougal's silence.The New Yorker?published an article last month that referenced an eight-page document McDougal wrote about the alleged affair, which a friend provided to the magazine and McDougal confirmed.Adult film actress Stormy Daniels has taken Trump and his personal attorney, Michael Cohen, to court in an attempt to end a nondisclosure agreement that is alleged to require her to keep silent about an affair she had with Trump over a decade ago. Cohen and the White House have denied the affair.Cohen admitted last month to facilitating a payment to Daniels, whose legal name is Stephanie Clifford, and lawyers for both him and Trump have claimed Clifford has violated the nondisclosure agreement and could owe a monetary penalty of more than million.The Times report said McDougal's suit claims Cohen was "secretly involved" in her talks with American Media Inc., and outlines a number of similarities between the two. Both alleged affairs started in 2006, and both women originally shared the same attorney, Keith Davidson of Los Angeles.In response to the original Journal story about the Enquirer and McDougal, American Media Inc. denied paying to kill damaging stories about Trump.The news of McDougal's suit came as New York judge allowed a defamation case brought by Summer Zervos, who has accused Trump of sexual assault, to move forward by denying a defense motion to dismiss the case. 2376

A man is hospitalized after a flight heading to Tulsa, Okla. was diverted to Phoenix's Sky Harbor International Airport due to an odor on-board.A Frontier Airlines flight that took off from San Diego had to land in Phoenix due to the odor, fire officials said.The plane landed without incident and most passengers were able to de-board from the plane, a Phoenix fire spokesman said. Seventeen people were evaluated as a precaution after an "odor came through the plane and was then gone," a fire spokesman said. A 62-year-old man was taken to the hospital.The cause of the odor is being investigated by Frontier Airlines. 639

A House committee issued a scathing report Wednesday questioning whether Boeing and government regulators have recognized problems that caused two deadly 737 Max jet crashes and whether either will be willing to make significant changes to fix them.Staff members from the Transportation Committee blamed the crashes that killed 346 people on the "horrific culmination" of failed government oversight, design flaws and a lack of action at Boeing despite knowing about problems. The committee said the Max complied with FAA safety regulations even though the planes crashed in Indonesia and Ethiopia. Members say this shows a need for reforms. Boeing says it's made changes and it cooperated with House investigators. A message was left seeking comment from the FAA. 772

A football coach. An athletic director. And young, fresh-faced students.They are among the 17 people killed by a gunman at Marjory Stoneman Douglas High School in Parkland, Florida, on Wednesday.Broward County Sheriff Scott Israel said Thursday that all families who lost loved ones in the shooting have been notified.  332

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