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HONG KONG, July 19 (Xinhua) -- A gene controlled by male hormone was critical for the growth of liver tumor, leading to a higher incidence of the disease in men than in women, according to the Chinese University of Hong Kong which made the results public on Tuesday.There is a significant gender bias in liver cancer incidence. In Hong Kong, men are three times more likely to develop liver cancer than women. Such phenomenon prompted researchers from the university to carry out a genomic location analysis in liver cancer cells starting from 2008.The researchers discovered, out of 17,000 human genes, that a gene called Cell Cycle-Related Kinase (CCRK) was directly controlled by androgen receptor. They further found that CCRK was critical for the induction of signaling pathway leading to abnormal liver cell growth and tumor formation.The results also reveal that 70 percent of patients with liver cancer were found to produce high levels of CCRK. More importantly, these patients were more likely to have late-stage cancers and lived shorter than those with low CCRK level.Using mouse models, the researchers found that either lowering the level or blocking the signaling pathway of CCRK in liver cancer cells could significantly reduce the tumor growth rate.The study has validated that CCRK is an important gene that has potential to cause liver cancer and the gene can be tested as a new targeted therapy in future.Vice-Chancellor of the university Joseph Sung, who is also team leader of the research project, said the results explained why men have a higher risk of liver cancer than women and helped push ahead with the development of a novel treatment of the disease.The above study results were published online in July in Journal of Clinical Investigation.

LOS ANGELES, June 4 (Xinhua) -- Pregnant women who eat high-fat diet may be more likely to have a higher rate of stillbirth, a new study suggests.Researchers at Oregon Health & Science University (OHSH) came to the conclusion after observing 24 pregnant Japanese macaques that ate either a diet comprising 32 percent calories from fat or a control diet with 14 percent fat calories for at least four years.The researchers found the monkeys that ate a high-fat diet experienced a significant decrease in blood flow from the uterus to the placenta, a reduction of 38 percent to 56 percent, and a rise in placental inflammation.This was the case regardless of whether the monkeys were obese or slender. The risk of stillbirth was further compounded, however, when the monkeys were obese with hyper-insulinemia, or pre-diabetes.A large order of McDonald's french fries are shown May 22, 2008. McDonald's has switched to cooking oils free of trans fats in all of its restaurants in the United States and Canada, Chief Executive Jim Skinner said on may 23Eating a high-fat diet decreases blood flow from the mother to the placenta, the temporary organ that nourishes the unborn fetus, thus raising the risk of stillbirth, the researchers explained.Because the placental structure of the Japanese macaque is very similar to that in humans, cause and effect can be better established, the researchers said.Additional studies are needed to determine exactly how a high- fat diet decreases placental blood flow, the researchers noted.This is the first study to explain exactly how a fatty diet contributes to stillbirth, the researchers said in the study appearing in the June edition of the journal Endocrinology.The researchers hope their work will inform expectant moms and their physicians about the inherent dangers of a high-calorie, high- fat diet."This study demonstrates that maternal diet during pregnancy has a profound influence on both placental and fetal development," said Antonio Frias, M.D., principal investigator and assistant professor of obstetrics and gynecology (perinatology/maternal-fetal medicine) in the OHSU School of Medicine."The high-calorie, high-fat diet common in our society has negative effects on placental function and may be a significant contributor to adverse pregnancy outcomes, such as stillbirth."Previous studies have shown that nearly all adverse outcomes during pregnancy -- abnormal fetal growth, preeclampsia, preterm labor and stillbirth -- are in some way associated with an abnormally developed, or damaged, placenta, the temporary organ that nourishes the unborn fetus.In addition, maternal obesity has been associated with placental inflammation and dysfunction and an increased risk of stillbirth.Taking these findings into account, the researchers hypothesized that eating a diet high in fat during pregnancy also may increase the risk of placental inflammation and the risk of stillbirth.The researchers said they plan to conduct further studies on the impact of dietary changes and diet supplementation on improving outcomes in both monkeys and humans.

BEIJING, Aug. 2 (Xinhuanet) -- The first close-up pictures of the asteroid Vesta, a protoplanet that dates back to the early days of the solar system, were revealed Monday by NASA scientists.The images were taken by the U.S. space agency's Dawn robotic probe, which is two weeks into a planned year-long survey of the second largest object in the main asteroid belt, located between Mars and Jupiter.About twice the size of California, Vesta is second in size only to Ceres, Dawn's next target and, along with Pluto, one of just five known dwarf planets. NASA is spending 466 million dollars to explore Vesta and Ceres during the course of a 10-year mission.Images from Dawn show Vesta a surprisingly diverse terrain and several unexplained geologic features. Chaotic terrain near the south pole is dominated by a towering central peak and huge ripple-like grooves stretching around its equatorial belt. Bright spots, dark pits and craters are filled with unexplained streaks of black and white debris. Terrain north of the grooves is much more heavily cratered.Scientists believe Vesta grew from a clump of gas and dust left over after the sun's birth some 4.65 billion years ago, a supernova explosion, which added radioactive materials to the growing body.Dawn will spend about a year circling Vesta, tweaking its orbit and altitude using an innovative technology called ion propulsion system, chief engineer Marc Rayman with NASA's Jet Propulsion Laboratory in California said.The ion propulsion system will enable Dawn to leave Vesta's orbit after a year of study and head off to Ceres, which is the largest object in the asteroid belt.

CHONGQING, May 28 (Xinhua) -- Non-infectious chronic diseases have become the major threat to human health in China as deaths from such diseases account for 85 percent of annual total deaths in the country, a report issued Saturday warned.The report said a 2008 national survey on mortality cause in China showed that the figure was up from 53 percent in 1973. Such diseases result in 3.7 million deaths annually.The Disease Prevention and Control Bureau under the Ministry of Health, and the Chinese Center for Disease Control and Prevention conducted the study, which was released at a national forum on prevention and control of chronic diseases in Chongqing.The mortality-cause survey shows that four non-infectious chronic diseases -- Cerebrovascular disease, cancer, respiratory disease and heart disease -- are the four principal causes that led to the largest number of deaths in China.Chronic diseases are the leading cause of mortality in the world, accounting for 60 percent of all deaths, reports the World Health Organization.According to the report, changes in lifestyle is one of the reasons that chronic diseases are increasing. Food with high contents of fat, protein and salt can lead to high blood pressure, high blood-fat and high blood sugar. Meanwhile, more people ride in vehicles instead of walking, meaning they exercise less.Experts at the forum called for more efforts to prevent and treat chronic diseases."It allows no delay," Kong Lingzhi, the vice director of the Disease Prevention and Control Bureau said, underlining the importance of reinforcing public education on chronic disease prevention and control."The earlier patients are aware of chronic diseases and receive proper medical treatment, the more likely they could overcome the diseases," she said.According to Kong, China has set a strategy to cope with chronic diseases in which government assumes the main responsibility, while the focus is on prevention.She said China would work to establish a prevention mechanism that pools the efforts of households, communities, professional institutions, and society at large.

LOS ANGELES, June 24 (Xinhua) -- Near-Earth asteroid 2011 MD will whip past Earth on June 27, but will not pose any threat, NASA's Jet Propulsion Laboratory (JPL) said on Friday.The asteroid will pass only 12,000 kilometers (7,500 miles) above the Earth's surface at about 9:30 EDT, according to JPL in Pasadena, Los Angeles.This small asteroid, only 5-20 meters in diameter, is in a very Earth-like orbit about the Sun, but an orbital analysis indicates there is no chance it will actually strike Earth on Monday, JPL said.If a rocky asteroid the size of 2011 MD were to enter Earth's atmosphere, it would be expected to burn up high in the atmosphere and cause no damage to Earth's surface, said JPL.The accompanying diagram gives a view of the asteroid's trajectory from the general direction of the Sun. This view indicates that 2011 MD will reach its closest Earth approach point in extreme southern latitudes (in fact over the southern Atlantic Ocean), according to JPL. The incoming trajectory leg passes several thousand kilometers outside the geosynchronous ring of satellites and the outgoing leg passes well inside the ring, JPL said.For a brief time, it may be bright enough to be seen even with a modest-sized telescope.One would expect an object of this size to come this close to Earth about every six years on average.The asteroid was discovered by the LINEAR near-Earth object discovery team observing from Socorro, New Mexico.