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Researchers published what they say is the first case of a living person diagnosed with the degenerative brain disease chronic traumatic encephalopathy or CTE.While unnamed in the study, lead author Dr. Bennet Omalu confirmed to CNN that the subject of the case was former NFL player Fred McNeill -- who died in 2015.Omalu is credited with first discovering CTE in professional football players. Until now, the only way to diagnose the disease is with a brain exam after death.The diagnosis was first made using an experimental brain scan that can trace a signature protein of CTE called tau. The authors then confirmed the diagnosis with an autopsy. The case study was published in the journal Neurosurgery this week.'It looked like just depression'Omalu first presented these findings exclusively to CNN's chief medical correspondent, Dr. Sanjay Gupta, in 2016. McNeill's wife, Tia, and his two sons, Gavin and Fred Jr., told Gupta then that they saw Fred transform from a fun loving family man at the center of their lives into a man who was dealing with symptoms of memory loss, anger and depression that tore their family apart."There are some times where the father is the stronghold in the family, or the anchor. If you lose that, everything kind of falls apart. That's kind of what happened for us. It looked like financial issues at first; it looked like marital issues, and they separated; then it looked like just depression," Gavin told Gupta.CTE is known for plaguing people with Alzheimer's like symptoms such as memory loss, rage, mood swings, and in some cases, suicidal ideation.Severity of the disease is categorized into four stages, with stage 4 being the most severe. While researchers don't know exactly why certain people develop the disease and others don't, they believe that it results from repeated blows to the head that trigger a build up of tau proteins in the brain.CTE has been called football's "concussion crisis," however experts point out that CTE can develop from any repeated head injury. According to the Boston University CTE Center, "this trauma includes both concussions that cause symptoms and subconcussive hits to the head that cause no symptoms." These subconcussive hits can include the repeated trauma the brain experiences from constant plays, hitting the turf, and tackling. Wrestlers, boxers, and military troops have also been diagnosed with the disease.Seeing CTEWhile McNeill is the first case to be confirmed with an autopsy, the experimental technology has been used on at least a dozen other former NFL players, including Pro Football Hall of Famer, Dallas Cowboy Tony Dorsett. Omalu helped develop and is invested in the diagnostic exam, which uses a radioactive "tracer" called FDDNP to bind to tau proteins in the brain. The tau proteins can then be seen on a PET scan of the brain.Critics have said the protein also can highlight another protein called amyloid, which may be indicative of Alzheimer's or other forms of dementia. But Omalu noted that in CTE, tau makes distinctive patterns in the brain. It has a "specific topographic signature," he said, and that pattern can be detected in imaging.Omalu said he and his team are currently raising money to start a phase 3 clinical trial to further test the technology and replicate what they have seen in McNeill. He anticipates that once funds are raised, it will take another two to three years for the trial and then another year, at least, for approval from the US Food and Drug Administration. When asked, how soon a commercial test could be available, Omalu predicted it could be as soon as a few years. "We are looking at less than five years," he said. 3711
PROVIDENCE, R.I. (AP) — Eight acrobats injured when the rigging suspending them by the hair plummeted to the floor during a circus performance in Rhode Island in 2014 have reached a .5 million settlement with ownership and management of the arena where the circus was held.Zachary Mandell, an attorney for the women, confirmed the settlement, first reported by The Providence Journal.A metal clip that held the acrobats 20 feet above the floor of the Dunkin' Donuts Center snapped.The women sued the Rhode Island Convention Center Authority, which owns the arena, and SMG, which manages it.According to the Associated Press, SMG arranged with Feld Entertainment to bring the Ringling Bros. and Barnum & Bailey Circus to Providence.The Department of Labor's Occupational Safety and Health Administration (OSHA) found that the clip was overloaded after the accident, so they cited Feld and imposed a fine, the AP reported.An attorney for both entities said he could neither confirm nor deny a settlement.Mandell added that insurers would pay the settlement. 1070

President Trump's steel tariff could cost Ford and General Motors billion a year.That's the hit each company could take if the tariff translates into a similar increase in steel prices, according to a Goldman Sachs analysis. Trump has proposed a 25% tariff on imported steel, along with a 10% tariff on aluminum. billion represents 12% of Ford's profit last year and 7% of GM's, the analysis said.The report looked at Ford and GM's 2017 production mix to make its calculation.Ford said in a statement that the tariffs "could result in an increase in domestic commodity prices — harming the competitiveness of American manufacturers." GM said it supports trade policies "that enable U.S. manufacturers to win and grow jobs in the U.S."Both automakers say they use mostly American-made steel for vehicles they make in the United States.Trump argues that the tariffs will bolster US production of steel and aluminum and combat unfair trade practices. But businesses outside the steel and aluminum industries have warned that the tariffs will lead to higher prices and hurt the economy.The American International Automobile Dealers Association, which was formed to advocate free trade, said car prices could go up "substantially." The group also warned that retaliatory tariffs from other countries could drive up the price of US goods in general. 1366
President Donald Trump’s former adviser Kellyanne Conway said late Friday that she has tested positive for the coronavirus, days after attending a White House event with several others who have since come down with COVID-19.Conway tweeted Friday that she has a “light cough” and is “feeling fine.” “I have begun a quarantine process in consultation with physicians,” she added.Conway attended the Rose Garden announcement Saturday where President Donald Trump announced his nomination of Judge Amy Coney Barrett to the Supreme Court. Among the attendees, Republican Sens. Mike Lee and Thom Tillis, the president of the University of Notre Dame, as well as Trump himself tested positive Friday for the coronavirus. 721
Reports indicate that Toys R Us could be the next retailer to file for bankruptcy.The Wall Street Journal reports that the toy retailer could file for Chapter 11 bankruptcy in the next few weeks, just a few months out from the crucial holiday season.According to the Journal, the chain's suppliers are hesitant to ship new items before putting money down. The company is facing a debt of billion stemming from a leveraged buyout in 2005.Toys R Us has already received most of its holiday shipments, but could soon be prevented from receiving any additional toys before the shopping season begins.Toys R Us is just one of a number of retailers who have struggled as Americans have started doing more of their shopping online. Just this year, at least 18 major retailers have announced that they plan on closing a significant number of stores.Read the Wall Street Journal's report here.Alex Hider is a writer for the E.W. Scripps National Desk. Follow him on Twitter @alexhider. 1004
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