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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086

A group of Republicans in the House of Representatives have formally nominated President Donald Trump for the 2019 Nobel Peace Prize.In a letter addressed to Berit Reiss-Andersen, the chair of the Nobel Committee, the group nominated Trump on the basis of his work to end the war between North and South Korea."Since taking office, President Trump has worked tirelessly to apply maximum pressure on North Korea to end its illicit weapons programs and bring peace to the region. His Administration successfully united the international community, including China, to impost one of the most successful international sanctions regimes in history. The sanctions have decimated the North Korean economy and have been largely credited for bringing North Korea to the negotiating table," the letter reads in part.The letter is signed by Indiana Rep. Luke Messer and 17 other Republican members of Congress.   929

A federal judge halted construction of the controversial Keystone XL oil pipeline on Thursday, in a blow to the Trump administration and a win for environmental groups.US District Judge Brian Morris found that the US government's use of a 2014 environmental review to justify issuing a presidential permit for construction of the cross-border pipeline violated the National Environmental Policy Act, the Endangered Species Act and the Administrative Procedure Act, according to the court order issued Thursday."The Court enjoins Federal Defendants and TransCanada from engaging in any activity in furtherance of the construction or operation of Keystone and associated facilities," the court document reads, "until the Department has completed a supplement to the 2014 SEIS (Supplemental Environmental Impact Statement) that complies with the requirements of NEPA and the APA."Environmental groups involved in bringing the 2017 lawsuit celebrated the decision."Keystone XL would be a disaster for the climate and for the people and wildlife of this country," said Jackie Prange, senior attorney at the Natural Resources Defense Council, one of the plaintiffs. "As the court has made clear yet again, the Trump administration's flawed and dangerous proposal should be shelved forever."In March 2017, President Donald Trump's administration issued a permit approving construction of the pipeline, reversing the Obama administration's decision to block the controversial project.The White House has not responded to CNN's request for comment on the judge's order.The permit approval followed years of intense debate over the pipeline amid steadfast opposition from environmental groups.They argued that the pipeline would support the extraction of crude oil from oil sands, a process that pumps more greenhouse gases into the atmosphere than standard crude oil extraction. They also opposed the pipeline because it would run across one of the world's largest underground deposits of fresh water.Native American groups argued the pipeline would cut across their sovereign lands.The-CNN-Wire 2099

A historically active Atlantic Hurricane season is nearing a close, but there appears to be at least one more threat looming in the Caribbean Sea.Hurricane Zeta is currently churning just south of the Yucatan Peninsula with maximum sustained winds of 80 mph — and is currently projected to make landfall on the Louisiana coast later this week.The National Hurricane Center issued a hurricane watch for portions of the Louisiana and Mississippi coasts on Monday. The hurricane watch runs from Morgan City, Louisiana to the Alabama/Mississippi border. The hurricane gained hurricane status Monday afternoon after Hurricane Hunters flew through the storm. In addition to gustier winds, the Hurricane Hunters found Zeta's pressure has dropped. According to the National Hurricane Center's latest update, Zeta is projected to make landfall on the eastern part of the Louisiana coastline on Wednesday evening or early Thursday morning. At that point, officials believe the system will be "at or near hurricane strength."Zeta is the 28th named storm of 2020 — the second-most all-time in a single year. And no region has been targeted more by tropical storms this year than the Louisiana coast.The Louisiana coastline has already been targeted by four major storms this year — Cristobal, Laura, Marco and Delta. The strongest of those storms, Laura, reached category 4 status and caused extensive damage to the Lake Charles area, contributing to 17 deaths in the U.S.According to one NOAA researcher, the Louisiana coast has spent more than three whole weeks in NHC forecast cones this year, by far the most of any region. 1624

A little girl with a passion for writing letters is now becoming a published author.Emerson Weber went viral earlier this year when her dad tweeted her story.Emerson had about a dozen pen-pals at the time. She writes them letters filled with jokes and stories, and she always decorates the envelopes.“It's like a little piece of art that someone's going to find in their mailbox, and I get my inspiration from everywhere,” said Weber, author of “Sincerely, Emerson.”Weber wanted to thank her mail carrier for always taking all her letters, so she wrote him too. Her mail carrier then shared that letter with his supervisor at work, who shared it regionally, and the responses poured in. Two boxes full of letters from postal workers arrived.Some sent back stamps or asked her to send a letter to more people in their family.Many postal workers said they felt seen for the first time in a long time, and she wrote back to all of them.“In this time that's a little crazy, they're still out there doing their job, so we can stay connected to our pen pals and people we love,” said Weber.After her story spread online, even more people from all over started writing Weber.She hopes when people read her book, they realize how one act of kindness can spread.“And I also hope they take the time to write a letter because people really appreciate that,” she said. “Your grandparents, your friends, anyone would really love to get a letter from you and it's just so meaningful.”Her picture book based on the viral story, “Sincerely Emerson,” comes out next week. 1562