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BEIJING, Aug. 22 (Xinhuanet) -- Researchers have discovered how a human egg captures an incoming sperm for fertilization, paving the way to help couples suffering from infertility, according to media reports on Monday.An international team of researchers found that a sugar chain known as the sialyl-lewis-x sequence (SLeX) makes the outer coat of the egg “sticky,” which has proven to be helpful in binding the egg and the sperm.As a result, this observation has filled in a huge gap in the understanding of fertility and provides hope for ultimately helping couples who currently cannot conceive.Scientists and doctors know that a sperm identifies an egg when proteins on the head of the sperm match and bind to a series of specific sugars in the egg’s outer coating. With a successful match of proteins, the outside surfaces of the sperm and egg then bind together before merging, which is then followed by delivery of sperm’s DNA into egg.To identify this molecules, the researchers used ultra-sensitive mass-spectrometric imaging technology to observe and identify which molecules are most likely to be key in the binding process.They experimented with a range of synthesised sugars in the laboratory and found that it is SLeX that specifically binds sperm to an egg.According to the World Health Organisation, infertility affects about 15 percent of reproductive-aged couples around the world and almost one in every seven couples in Britain has problems conceiving a child for various reasons.

BEIJING, Aug. 12 (Xinhuanet) -- The risk of developing coronary heart disease is 25 percent higher for women smokers compared with men, according to a study published in the British medical journal "The Lancet".The authors say this could be due to the physiological differences between the sexes with cigarette smoke toxins having a more potent effect on women.The study by Dr Rachel R Huxley from the University of Minnesota and Dr Mark Woodward from Johns Hopkins University involved a meta-analysis of around four million individuals and 67,000 coronary heart disease events from 86 studies.The researchers found that the pooled adjusted female-to-male relative risk ratio (RRR) of smoking compared with not smoking for coronary heart disease (CHD) was 1.25 (25 percent) higher for women.This RRR increased by 2 percent for every additional year of follow-up, meaning that the longer a woman smokes, the higher her risk of developing CHD becomes compared with a man who has smoked the same length of time.The authors say, "The finding lends support to the idea of a pathophysiological basis for the sex difference. For example, women might extract a greater quantity of carcinogens and other toxic agents from the same number of cigarettes than men. This occurrence could explain why women who smoke have double the risk of lung cancer compared with their male counterparts."Worldwide, there are 1.1 billion smokers, of whom a fifth are women.According to the Tobacco Atlas, India, with around a crore female smokers, ranks third in the top 20 female smoking populations across the globe, only the U.S. with 2.3 crore female smokers and China with 1.3 crore female smokers, are worse off.

JOHANNESBURG, June 1 (Xinhua) -- An estimated 2 million adolescents ages 10 to 19 are living with HIV, with 86 percent of them from sub-Saharan Africa, according to a global report on HIV prevention launched in Johannesburg on Wednesday.For the first time, the world gets to see the number of adolescents between the ages of 10 to 19 living with HIV in the report named Opportunity in Crisis: Preventing HIV from early adolescence to young adulthood.The report is a jointly publication by the United Nations Children's Fund (UNICEF), UNAIDS, the United Nations Educational, Scientific and Cultural Organization (UNESCO), the United Nations Population Fund (UNFPA), the International Labor Organization (ILO) , the World Health Organization (WHO) and World Bank.According to the report, people aged 15-24 accounted for 41 percent of new infections over the age of 15 in 2009. Worldwide, an estimated 5 million young people in that age group were living with HIV in 2009. Most of them live in sub-Saharan Africa. Globally, young women make up more than 60 percent of all young people living with HIV. In sub-Saharan Africa that rate jumped to 72 percent.Despite these challenges, the report acknowledges that some progress has been made in preventing new infections among young people."In many high-burden countries, HIV prevalence and incidence have declined among young people. While in 2001 there were 5.7 million young people living with HIV, the figure stands at 5 million (in 2009)," said the UNICEF eastern and southern Africa regional director, Elhadj As Sy, at the media briefing.He pointed that sexual transmission and injection drug use remain the major modes of transmission of HIV among young people. Early sexual debut, early pregnancy and early experiences with drug use all raise risks for HIV infection.The report reveals that unemployment and poverty are reported as the main reasons young people enter the sex trade. Worldwide, many young people driven by economic pressure, exploitation, social exclusion and lack of family support turn to commercial sex and injecting drug use.In 2001, the world made a commitment to reduce the prevalence of HIV among young people by 25 percent by 2010. The actual reduction achieved (from 5.7 million to 5 million) is 12 percent, and it represents less than half the target percentage."To avoid the current programming failures, we have to adopt a ' Continuum of Prevention Approach'." said Lina Mousa, deputy director of UNFPA Africa Regional Office."This continuum of prevention must be reflected in national HIV strategic plans, poverty reduction strategies and global fund proposals. This response must be developed with and for young people so that they own the response together with their communities," she added.To build this continuum of prevention for adolescents and young people, the reports outlined nine specific recommendations including providing young people with information and comprehensive sexuality education, strengthening child protection and social protection measures, engaging communities in shaping a positive social environment that promotes healthy behavior, establishing laws and policies that respect young people's rights.

SAN FRANCISCO, June 1 (Xinhua) -- Microsoft on Wednesday gave a preview of its next-generation operating system code-named "Windows 8."The software giant introduced the successor to Windows 7 at the ninth edition of The Wall Street Journal's Digital: All Things Digital in Rancho Palos Verdes, California, some 48 km south of Los Angeles.With an interface quite different from legacy Windows, Windows 8 looks more like Windows Phone 7 and features an app management from Windows mobile operating system. It is the first major attempt by Microsoft to expand a mobile operating system to desktop status, and is expected to be touch-friendly and work seamlessly on desktops, laptops and tablet computers.For legacy Windows users, they need to swipe up from the bottom of the screen to get to the Windows 7-based view. Microsoft said the new system will be compatible with all Windows 7 logo PCs, software and peripherals.During the demonstration, Steven Sinofsky, Microsoft's head of Windows, also said the importance of not abandoning the established technologies from the traditional PC. "The mouse and the keyboard aren't evil. They're just tools. There are a number of applications that require the greater precision offered by the mouse." said Sinofsky.Sinofsky did not say when Windows 8 would be available.Although there are some tablets running Microsoft's current Windows 7 operating system, the software giant has been criticized for failing to adequately respond to the fast growth of tablet computers, like Apple's iPad.

WASHINGTON, July 15 (Xinhua) -- Researchers at Mount Sinai School of Medicine have found that grape seed polyphenols -- a natural antioxidant -- may help prevent the development or delay the progression of Alzheimer's disease.The research, led by Giulio Pasinetti, was published online Friday in the Journal of Alzheimer's Disease, which causes brain changes that gradually get worse.This is the first study to evaluate the ability of grape- derived polyphenols to prevent the generation of a specific form of amyloid (A) peptide, a substance in the brain long known to cause the neurotoxicity associated with Alzheimer's disease.In partnership with a team at the University of Minnesota, Pasinetti and collaborators administered grape seed polyphenolic extracts to mice genetically determined to develop memory deficits and A neurotoxins similar to those found in Alzheimer's disease. They found that the brain content of the A*56, a specific form of A previously implicated in the promotion of Alzheimer's disease memory loss, was substantially reduced after treatment.Previous studies suggest that increased consumption of grape- derived polyphenols, whose content, for example, is very high in red wine, may protect against cognitive decline in Alzheimer's. This new finding corroborates those theories."Since naturally occurring polyphenols are also generally commercially available as nutritional supplements and have negligible adverse events even after prolonged periods of treatment, this new finding holds significant promise as a preventive method or treatment, and is being tested in translational studies in Alzheimer's disease patients," said Pasinetti.In Alzheimer's disease, brain cells degenerate and die, causing a steady decline in memory and mental function.

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