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WELLINGTON, Aug. 8 (Xinhua) -- A New Zealand study has found that people who work at least 50 hours a week can be up to three times more at risk of alcohol problems than people who work fewer hours.The study, conducted by the University of Otago, used data that followed more than 1,000 people born in Christchurch in 1977 through to age 30.Study leader Dr Sheree Gibb said it aimed to examine whether working hours were related to alcohol problems in early adulthood.Data from more than 1,000 participants at ages 25 and 30 showed a significant association between longer working hours and alcohol- related problems.Longer working hours were associated with higher levels of alcohol problems including frequent alcohol use and alcohol abuse or dependence.People who worked 50 hours or more on average a week were 1.8 to 3.3 times more likely to have alcohol-related problems than those who were not working, and about 1.2 to 1.5 times more likely to have alcohol-related problems than those who worked 30 to 49 hours a week.The higher risk of alcohol abuse for those who worked longer hours was evident in both men and women, according to the study.Gibb said the finding could suggest a need for consideration of policies and programs targeting individuals who worked long hours, with the aim of reducing rates of alcohol-related problems.The article had been accepted for publication by the UK-based journal Addiction.
STOCKHOLM, July 7 (Xinhua) -- A patient has been given a new trachea made from a synthetic scaffold seeded with his own stem cells in a Stockholm's hospital, the Swedish medical university Karolinska Institutet said on Thursday.The operation was performed on June 9th at Karolinska University Hospital in Huddinge and the patient, a 36-year old man, has been well on the way to recovery and would be discharged from the hospital on Friday, the university said in a statement.The patient had been suffering from late stage tracheal cancer with the tumor had reached approximately 6cm in length and was extending to the main bronchus.Since no suitable donor windpipe was available, the transplantation of the synthetic tissue engineered trachea was performed as the last possible option for the patient.The successful transplantation of tissue engineered synthetic organs, referred to as regenerative medicine, could open promising therapeutic possibilities for the thousands of patients who suffer from similar conditions.Transplantations of tissue engineered windpipes with synthetic scaffolds in combination with the patient's own stem cells as a standard procedure means that patients would not have to wait for a suitable donor organ.This would be a substantial benefit for patients since they could benefit from earlier surgery and have a greater chance of cure, according to the statement.

SHENZHEN, June 18 (Xinhua) -- China established its first national gene bank on Friday in south China's city of Shenzhen with the support of the Beijing Genomics Institute (BGI), officials said.With the establishment of the National Gene Bank in Shenzhen, China will be able to better protect, research and utilize its precious genetic resources, boosting the genetics industry and safeguarding the country's genetic information, said Qi Chengyuan, head of the high-tech industry department of the National Development and Reform Committee (NDRC).The gene bank, which was approved by the NDRC in January, is based on data and facilities belonging to the BGI, but will grow with the help of extensive cooperation with other biological organizations both home and abroad, Qi said.The national gene bank "aims to lead the development of international bioindustry as one of the world's largest gene banks," said Yang Huanming, the BGI's president.The BGI, the world's largest genome-mapping institute, has more than 1,000 biological analysis devices working with top-of-the-line genome-sequencing machines.Analysts say the BGI differs from conventional labs, as it can handle data in vast quantities and industrialize its research. Some believe lower wages in China have also contributed to the BGI's competitiveness.Yang Bicheng, the BGI's spokesman, said the payment and welfare packages BGI offers are competitive in China's bioindustry."A researcher with about two years of experience earns around 100,000 yuan (15,440 U.S. dollars) a year. More outstanding researchers can get more, but the gap is not too great," Yang said.Yang said greater motivation comes from better prospects for academic achievements."Our young researchers can work with the world's leading scientists, participate in global science projects and be pioneers in new fields of research. Only BGI offers these kinds of opportunities in China," Yang said.The BGI has published 18 research papers in Science Magazine and the Nature Journal since 2007. The facility has become an international center for genome research and industrialization, with advanced technology and top talent, said Ji Xiaoming, head of the international cooperation department of the Ministry of Science and Technology.China is working to make its genetic research industry into one of the country's pillar industries.A plan approved by the State Council, or China's cabinet, in October 2010 said China will boost the industry by encouraging innovation, promoting industrial application of biological research, fostering market demand and deepening international cooperation.
WASHINGTON, Aug. 4 (Xinhua) -- U.S. scientists have found two gene mutations occurring in oligodendrogliomas, the second-most common form of brain cancer, according to a study to be published Friday in journal Science.For years scientists have been looking for the primary cancer genes involved in oligodendrogliomas evolvement. Scientists know the two chromosomes held the probable mutations, but the particular gene information remains unclear.Now scientists at Duke University Medical Center and Johns Hopkins University have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19.The genes they identified, CIC or FUBP1, are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, said Hai Yan, a Duke associate professor of pathology and co-corresponding author of the study.The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas. They found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.These genes were difficult to find until the technology improved, said Yan."The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist both in reducing the chance of relapsing and increasing odds of success.
HONG KONG, Sept. 9 (Xinhua) -- The Hong Kong Polytechnic University (PolyU) announced Friday that its surveying experts had successfully developed methodologies for precise mapping of the Moon, after intensive analysis of the data captured by the Chinese lunar orbiter ChangE-1 and other lunar exploration missions.According to the PolyU, the team has made significant contributions to lunar mapping. Their efforts culminated in the development of a unique and innovative approach to the creation of accurate 3D models of the lunar surface.The team has produced the most updated parameters of the lunar figure (the shape of the moon), which is essential for lunar mapping using 17.5 million laser altimetry measurements from the ChangE-1and the Japanese SELENE missions.In addition, they also used the new topographic and gravity models to calculate improved crustal thickness and mass distribution of the Moon and established that the average thickness of the Moon's crust is about 40 km on the near side and 50 km on the far side.It was introduced that the resulting lunar mapping was the hard work of a dedicated research team led by Professor Chen Yong-qi, Emeritus Professor of the Department of Land Surveying and Geo-Informatics, who is also serving on the Expert Committee of China's Lunar Exploration Programme (ECCLEP), with the concerted efforts of team members Prof. Chen Wu, Prof. Ding Xiao-li, Prof. Baki Iz, Dr. Bruce King, and Dr. Wu Bo.According to Chen Yong-qi, the lunar mapping project started in 2006. The primary objective was to develop the methodologies and techniques for mapping the Moon surface, which is much more challenging than mapping the Earth's surface because of very few surveyed control points which are essential for accurate map making.Statistics showed that there were only fourteen lunar laser ranging retro reflectors (LRRR) and Apollo lunar surface experiment package (ALSEP) transmitter sites with accurately known coordinates available only on the near side of the Moon, installed by the U.S. Apollo and former Soviet Union Luna missions in the 1960s.Moreover, according to the team, the gravitational field of the Moon is not as well-known as that of Earth, which means the accuracy of the computed lunar satellite's position at any given time is lower than for Earth satellites, thus degrading the mapping accuracy and reliability.In addition, the team expressed that highly reflective lunar surface created significant problems for the automatic processing of images to develop 3D models using the technique of photogramemtry, which is a widely used and highly reliable technique for the creation of maps and 3D models on Earth.Furthermore, the team also revealed they had a plan to compare such data with other data sources in order to evaluate the performance of the ChangE mapping sensors. Since Chen Yong-qi is serving on the ECCLEP, the team has direct access to more recent data captured by the ChangE satellite.
来源:资阳报