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The US Food and Drug Administration approved Janssen Pharmaceuticals Inc.'s esketamine on Tuesday for treatment-resistant depression; the drug is the chemical cousin of ketamine, the powerful anesthetic that has been used illegally as the club drug Special K.It will be sold as Spravato. More specifically, it's for patients who have tried at least two other medications without success, and it should be taken with an oral antidepressant."There has been a longstanding need for additional effective treatments for treatment-resistant depression, a serious and life-threatening condition," Dr. Tiffany Farchione, acting director of the Division of Psychiatry Products at the FDA's Center for Drug Evaluation and Research, said in a 745

The Walt Disney Co. was built on the shoulders of Mickey Mouse, so it may come as a surprise that there never has been a theme park attraction based on the lovable rodent.That’s about to change with the debut of Mickey & Minnie’s Runaway Railway ride on Wednesday at Disney’s Hollywood Studios at Walt Disney World.The ride gives visitors the impression that they are watching a cartoon featuring Mickey and Minnie come to life as the Disney characters look for the perfect place for a romantic picnic and then end up on a train ride on the “Runnamuck Railroad.” The ride features trackless vehicles, multiple dimensional sets and projections on multiple planes, as well as animatronic figures and theatrical effects.“We’ve taken our whole grab bag of theatrical tricks and blended them together so seamlessly you won’t be able to tell what’s what,” said Kevin Rafferty, executive creative director at Walt Disney Imagineering. “There is more happening in each and every scene than you could possibly have time to see in just one experience.” 1058

Turkish artillery hit close to a US special operations unit near the Syrian city of Kobani on Friday, according to a US official familiar with the initial assessment.The artillery shells hit several hundred yards from where the US forces were located. There are no American injuries in the early reports and at this time no indication this was deliberate, the official said. 387

This is the time for Mexico, with the help of the United States, to wage WAR on the drug cartels and wipe them off the face of the earth. We merely await a call from your great new president!— Donald J. Trump (@realDonaldTrump) November 5, 2019 256

Tuesday marked the first day consumers could purchase Apple's new Mac Pro desktop computer, and it is already being scorned on social media for its price tag. While a basic model of the Mac Pro sells for ,999, Apple's upgrades to the computer could set a buyer back more than ,000. Yes, a computer on the consumer market is selling for more than most cars. There is no word on whether solitaire comes preinstalled. While the computer is on the consumer market, its designed for those who require "extreme performance." “We designed Mac Pro for users who require a modular system with extreme performance, expansion and configurability. With its powerful Xeon processors, massive memory capacity, groundbreaking GPU architecture, PCIe expansion, Afterburner accelerator card and jaw-dropping design, the new Mac Pro is a monster that will enable pros to do their life’s best work,” said Phil Schiller, Apple’s senior vice president of Worldwide Marketing. The computer features some expensive upgrades, which could add thousands to final cost. For instance, upgrading from an eight-core processor to a 28-core processor could add an additional ,000. Upgrading the memory to the computer from 32GB to 1.5 TB adds ,000 to the purchase price. An upgraded graphics card could cost as much as ,800. An upgrade to the story also could add ,400 to the price. The Mac Pro's large price tag has prompted many to poke fun at Apple on social media. 1464