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The US Food and Drug Administration has received 127 reports of seizures or other neurological symptoms possibly related to e-cigarettes, the agency announced Wednesday. Investigators have yet to determine, however, whether vaping was directly linked to the cases."The FDA is continuing its scientific investigation to determine if there's a direct relationship between the use of e-cigarettes and a risk of seizure or other neurological symptoms," said Dr. Ned Sharpless, the acting FDA commissioner.The FDA said the reported cases occurred between 2010 and 2019, and in addition to seizures, some people reported fainting or tremors. Sharpless said that "we still don't have enough information to determine if e-cigarettes are causing these reported incidents" but called on the public to continue submitting reports.Additional information "may help us identify common risk factors and determine whether any specific e-cigarette product attributes, such as nicotine content or formulation, may be more likely to contribute to seizures," he said.Dozens of new reports, no clear patternsIn April, the FDA announced that it had received 35 reports of seizures related to vaping, particularly among younger users. "Seizures or convulsions are known potential side effects of nicotine toxicity," the agency said at the time.There have been 92 new reports since then, but the FDA didn't announce any clear pattern across the cases.Cases were reported in both first-time and experienced e-cigarette users, and "seizures have been reported as occurring after a few puffs or up to one day after use," the FDA said in April. Several people had previously had a seizure diagnosis, the agency said at the time, and a few had also been using other drugs such as marijuana."Additional reports or more detailed information about these incidents are vital to help inform our analysis," Sharpless said Wednesday. Cases can be reported to the FDA 1943

The Trump administration said Wednesday it is appealing a federal judge's order that blocks the administration from implementing asylum restrictions on the southern border.According to a court filing, the administration told the 9th Circuit Court of Appeals it plans to appeal federal District Judge Jon Tigar's December 19 order, which extended an initial block on the new rules.President Donald Trump signed a presidential proclamation last month that would bar migrants who illegally cross into the United States over the southern border from seeking asylum outside of official ports of entry.Previously, a panel of judges on the 9th Circuit upheld Tigar's original temporary injunction in an opinion penned by federal Circuit Judge Jay Bybee, a George W. Bush nominee.And last week, the Supreme Court let stand Judge Tigar's original order temporarily blocking the Trump administration's new asylum restrictions in a 5-4 ruling in which Chief Justice Roberts sided with the four liberal justices.Trump has continually railed against the 9th Circuit as "very unfair." 1082

Top congressional negotiators clinched a "deal in principle" to fund the US government, an agreement that comes a little more than a week before the deadline and likely takes the threat of 201

The Pentagon has ordered an additional 8,000 ventilators, with delivery of the first 1,400 by early May. The .4 million order was placed with several suppliers under existing Defense Logistics Agency contracts.A Pentagon spokesman, Air Force Lt. Col. Michael Andrews, identified the four suppliers as Zoll, Combat Medical, Hamilton Medical, and VyAire. Andrews said delivery locations will be prioritized by FEMA and the Department of Health and Human Services. These are in addition to the 2,000 ventilators that the Pentagon previously said it would make available to FEMA from Defense Department stockpiles. 625

The U.S. Attorney's Office has announced arrests have been made in a “prolific” drug trafficking ring in Western New York.Four people have been arrested in a crime ring which stretches from Buffalo to Los Angeles, according to U.S. Attorney James Kennedy, Jr. Three of those people are from Buffalo: David Burgin, Rodney Pierce and David Washington are all charged with multiple drug crimes. 403