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New research suggests that antibodies the immune system makes to fight the new coronavirus may only last a few months in people with mild illness, but that doesn’t mean protection also is gone or that it won’t be possible to develop an effective vaccine.“Infection with this coronavirus does not necessarily generate lifetime immunity,” but antibodies are only part of the story, said Dr. Buddy Creech, an infectious disease specialist at Vanderbilt University. He had no role in the work, published Tuesday in the New England Journal of Medicine.The immune system remembers how to make fresh antibodies if needed and other parts of it also can mount an attack, he said.Antibodies are proteins that white blood cells called B cells make to bind to the virus and help eliminate it. The earliest ones are fairly crude but as infection goes on, the immune system becomes trained to focus its attack and to make more precise antibodies.Dr. Otto Yang and others at the University of California, Los Angeles, measured these more precise antibodies in 30 patients diagnosed with COVID-19 and four housemates presumed to have the disease. Their average age was 43 and most had mild symptoms.Researchers found that the antibodies had a half-life of 73 days, which means that half of them would be gone after that much time. It dovetails with a previous report from China also suggesting antibodies quickly fade.The results “call for caution regarding antibody-based ‘immunity passports,’ herd immunity, and perhaps vaccine durability,” the California authors write.That’s true, Creech said, but other parts of the immune system also help confer protection. Besides churning out antibodies, B cells develop a memory so they know how to do that again if needed.“They would get called into action very quickly when there’s a new exposure to the virus. It’s as if they lie dormant, just waiting,” he said.Other white blood cells called T cells also are better able to attack the virus the next time they see it, Creech said.Although circulating antibodies may not last long, what we need to know is if and how people remake antibodies if exposed to the coronavirus again and if they protect against another infection, Alison Criss, an immunologist at the University of Virginia, wrote in an email. “We also need to know if there is a protective T cell response” that reappears.Vaccines, which provoke the immune system to make antibodies, might give longer-lasting protection than natural infection because they use purified versions of what stimulates that response, she noted.Creech agreed.“This shouldn’t dissuade us from pursuing a vaccine,” he said. “Antibodies are only a part of the story.”___Marilynn Marchione can be followed on Twitter at http://twitter.com/MMarchioneAP___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2967
NEW YORK — Author Joanna Cole, whose “Magic School Bus” books transported millions of young people on extraordinary and educational adventures, has died at age 75. Scholastic says Cole, a resident of Sioux City, Iowa, died Sunday. With the ever maddening but inspired Ms. Frizzle leading her students on journeys that explored everything from the solar system to underwater, “Magic School Bus” books have sold tens of millions of copies and were the basis for a popular animated TV series and a Netflix series. Ms. Frizzle was based in part on a teacher Cole had growing up. Plans for a live-action movie, with Elizabeth Banks as Ms. Frizzle, were recently announced. 675

NEWPORT BEACH (CNS) - Ten firefighters and 11 lifeguards have recently tested positive for COVID-19 in Newport Beach, officials confirmed today.The numbers are a cumulative total throughout the past month and most have already returned to work, Fire Chief Jeff Boyles told City News Service.The infections apparently happened through community spread and not while the firefighters and lifeguards were on duty.Boyles told the Los Angeles Times that all fire stations and trucks remain staffed, but the department is not sending crews to help fight brush fires in other counties. 586
New details in the case of 13-year-old Patricia Alatorre who was allegedly raped and murdered last week by a man from Los Angeles who she communicated with on social media. The details in those court documents are very graphic, much of which wouldn't be appropriate to release.It was in the neighborhood near Wible Rd and Hosking Ave where police say 13-year-old Patricia Alatorre was kidnapped near her home last week. Documents revealed a lot of information about how she communicated with her suspected 24-year-old killer, the kind of communication they had prior to her death, and the tragic way she lost her life."That's sad. That's unacceptable. We don't want anybody killed, but it's incredibly sad when people kill children," said Kern County District Attorney Cynthia Zimmer.Zimmer shared her thoughts after court documents were released Wednesday morning detailing the tragic events leading up to Alatorre's death. Officials said she was killed in South Bakersfield shortly after midnight on July 2nd after 24-year-old Armando Cruz from Inglewood communicated with her on social media over the course of a week. They would send explicit photos to each other, according to documents.Things would take a turn for the worst, according to Bakersfield Police Sgt. Robert Pair."As you can imagine this is a particularly sensitive case. It's involving details that is especially graphic."Documents state Cruz convinced Alatorre to meet with him to engage in explicit acts on two occasions despite knowing she was only 13. He drove from Los Angeles to Bakersfield to meet her. On the second encounter, Cruz drove her around the block as she screamed, telling him she didn't want to go with him.It was about this time documents state she was raped. She tried to get up and physically struggled with Cruz and that's when he allegedly strangled her and tied her up with duct tape. He then took her body with him but the details following are too graphic to release.On Sunday night Cruz was arrested by BPD in Los Angeles County and brought back to Bakersfield. On Tuesday he was charged with 12 felony counts."The first count is first-degree murder and in connection with first-degree murder, I charged four special circumstances which carry the penalty of life without the possibility of parole, in prison, or the death penalty," explained Zimmer.Cruz has pleaded not guilty to that first-degree murder charge and all other felony charges, including kidnapping, and aggravated sexual assault. He is due back in court on July 30th. 2538
NEW YORK (AP) — In a sign of how the pandemic is remaking Hollywood traditions, AMC Theatres and Universal Studios on Tuesday announced an agreement for a shortened theatrical window, with the studio’s films playing for a minimum of just 17 days in cinemas compared to the typical 90 days.Studios have increasingly sought to shorten that window and deliver new movies more quickly into the home.After 17 days, Universal Pictures and Focus Features will have the option to make their films available across premium video on demand platforms, including Netflix, Amazon Prime and AMC Theatres On Demand.“The theatrical experience continues to be the cornerstone of our business. The partnership we’ve forged with AMC is driven by our collective desire to ensure a thriving future for the film distribution ecosystem and to meet consumer demand with flexibility and optionality,” said Donna Langley, Chairman of Universal Filmed Entertainment Group in a press release.This deal applies to U.S. theaters, international distribution between the two companies is still being negotiated.AMC and other theater chains have struggled during the pandemic as businesses closed earlier this year and indoor spaces face state-by-state guidance on social distancing and reopening policies.AMC says this multi-year deal with Universal is a commitment and belief that customers will come back.“We would note that just as restaurants have thrived even though every home has a kitchen, AMC is highly confident that moviegoers will come to our theatres in huge numbers in a post-pandemic world. As people enjoy getting out of their homes, we believe the mystical escape and magical communal experience offered at our theatres will always be a compelling draw," said AMC CEO Adam Aron in a statement.Universal said they are working with AMC and other distribution partners on restarting theatrical releases, including upcoming installments of Fast & Furious, Jurassic World, Despicable Me, and others.Tuesday's agreement repairs a rift between AMC and Universal brought on by the on-demand release of “Trolls World Tour” in April. The new deal covers Universal films in the U.S. over the next three years. 2195
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