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WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.
BEIJING, Feb. 10 (Xinhua) -- China's drought control authorities announced Thursday that hours of snowfall and irrigation have eased to some extent the severe drought in parts of the nation.Rapid spreading of the dry spell in the country's winter wheat producing regions has been curbed by wide-spread snowfall in the areas along the Yangtze, Huaihe and Yellow rivers and in the country's northern part on Wednesday and Thursday, the Office of State Flood Control and Drought Relief Headquarters said in a statement on its website.Drought-hit areas in Henan and Anhui, which are two major wheat-producing provinces, were reduced by 6.3 million mu (420,000 hectares) and 4.1 million mu, respectively, from Wednesday, the statement said. The agency added that irrigation also contributed to easing the effects of the drought.The statement said that as of Thursday, eight drought-hit provinces had irrigated 143 million mu of drought-affected wheat producing areas, which accounts for 52 percent of the combined winter wheat producing areas in the provinces. The eight provinces include the territories of Shandong, Henan, Hubei, Anhui, Shanxi, Shaanxi, Gansu and Jiangsu.As of 3 p.m. Thursday, the drought had affected 101.28 million mu of crops nationwide and left 2.81 million people and 2.57 million heads of livestock short of drinking water, said the statement.Cloud seeding on Wednesday and Thursday during a recent cold front, also helped alleviate drought in some regions, according to a report posted on the website of the China Meteorological Administration on Thursday.The report also said that the artificial precipitation had mitigated the shortage of moisture in the soil in parts of Henan and Anhui. The situation is expected to improve as the rain and snow continues.However, experts urged more measures from local governments to ensure winter wheat production since the current precipitation is not adequate to "completely ease the drought", the report said.

BAIKONUR, Kazakhstan, April 5 (Xinhua) -- Russian manned spacecraft Soyuz TMA-21 has been transported to the launch pad and raised to a vertical position, ready to blast off on April 5, Xinhua correspondents reported Saturday from the site.The launch is dedicated to the 50th anniversary of the first flight into space in 1961 carried out by Russian cosmonaut Yuri Gagarin.For hours, journalists and tourists from all over the world had braved a nasty weather and watched the train and trucks delivering the rocket to the pad.Service towers move towards the Soyuz TMA-21 spacecraft, named after the first cosmonaut Yuri Gagarin, as it is set on its launch pad at Baikonur cosmodrome April 2, 2011. The International Space Station (ISS) crew of U.S. astronaut Ronald Garan and crew mates Russian cosmonauts Alexandr Samokutyaev and Andrey Borisenko is due to travel by Soyuz spacecraft to the ISS on April 5.The Soyuz TMA-21 rocket will deliver three crew members to the International Space Station (ISS) on April 5. In a six-month mission, these cosmonauts will carry out over 40 experiments.The Soyuz TMA modification is a replacement of the Soyuz TM as it was equipped with smaller and more efficient computers and improved displays. The Soyuz TMA-21 will also serve as the return vehicle of the ISS crew.
WASHINGTON, April 13 (Xinhua) -- The U.S. Food and Drug Administration (FDA) announced on Wednesday that it has approved the cPAX Aneurysm Treatment System for surgery on brain aneurysms that are difficult to manage because of their size and shape.An aneurysm is a bulge in the wall of a blood vessel, which can rupture as it increases in size, causing hemorrhage or death. Brain aneurysms often produce no symptoms until they grow and press on nerves in the brain, or until they begin to leak blood or rupture.Aneurysms can be repaired in two ways: surgeons can close the base of the aneurysm with a surgical clip, or use a technique commonly known as coiling, in which surgeons use a catheter to thread metallic coils through a blood vessel in the groin and into the blood vessel in the brain that contains the aneurysm. Surgeons then fill the aneurysm with the detachable coils, which block it from circulation and cause blood to clot, effectively destroying the aneurysm.Aneurysms larger than 10 millimeters are difficult to treat with clipping or coiling. The cPAX device system is indicated for use in those brain aneurysms."Like coiling, the cPAX Aneurysm Treatment System is a form of endovascular repair," said Christy Foreman, director of the Office of Device Evaluation in the FDA's Center for Devices and Radiological Health. "But instead of tiny metallic coils, it uses a special polymer material to fill the space within the aneurysm."According to the FDA, the cPAX device system is indicated for use in adults aged 22 and older and should not be used in patients with an active infection or in those in whom anticoagulation and antiplatelet therapy is contraindicated.
LOS ANGELES, April 12 (Xinhua) -- With the help of NASA Telescopes, astronomers have uncovered one of the youngest galaxies in the distant universe, with stars that formed 13.5 billion years ago, the Jet Propulsion Laboratory (JPL) announced on Tuesday.The finding addresses questions about when the first galaxies arose, and how the early universe evolved, JPL noted in a press release.Infrared data from both the Hubble Space Telescope and the post- coolant, or "warm," phase of NASA's Spitzer Space Telescope mission revealed that the galaxy's stars are quite mature, which means they must have formed when the universe was just a toddler, said JPL in Pasadena, Los Angeles.This challenges theories of how soon galaxies formed in the first years of the universe and could even help solve the mystery of how the hydrogen fog that filled the early universe was cleared, according to astronomers involved in the study.This galaxy is not the most distant ever observed, but it is one of the youngest to be observed with such clarity, JPL said.Normally, galaxies like this one are extremely faint and difficult to study, but, in this case, nature has provided the astronomers with a cosmic magnifying glass, JPL said.The galaxy's image is being magnified by the gravity of a massive cluster of galaxies parked in front of it, making it appear 11 times brighter. This phenomenon is called gravitational lensing."Without this big lens in space, we could not study galaxies this faint with currently available observing facilities," said Eiichi Egami of the University of Arizona in Tucson. "Thanks to nature, we have this great opportunity to see our universe as it was eons ago."The findings may help explain how the early universe became " reionized," according to JPL."Seeing a galaxy as it appeared near the beginning of the universe is an awe-inspiring feat enabled by innovative technology and the fortuitous effect of gravitational lensing," Jon Morse, NASA's Astrophysics Division director at the agency's headquarters in Washington, said in the release."Observations like this open a window across space and time, but more importantly, they inspire future work to one day peer at the stars that lit up the universe following the big bang."
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