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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789

SAN DIEGO (CNS) - A woman and a man were attacked by a man with a knife in the East Village area of San Diego and the suspect was at large this morning.The 32-year-old woman was sitting near a Jack in the Box restaurant in the 1100 block of C Street, near Park Boulevard, at 10:40 p.m. Friday when a man walked up to her and, without saying anything, cut the left side of her face with a knife and ran away northbound on Park Boulevard, according to Officer Robert Heims of the San Diego Police Department.The victim was taken to a hospital with non-life threatening wounds.About a block away, the suspect approached a 62-year-old man and pressed a knife against the left side of the man's neck, then ran away in an unknown direction. The man suffered scratches to his neck, but did not go to a hospital, Heims said.A detailed description of the suspect was not immediately available. 892

SAN DIEGO (CNS) - A woman driving on a suspended license who had more than three times the legal blood-alcohol limit when she crashed her SUV head-on into another vehicle while driving her three young daughters through Rancho Bernardo was sentenced Thursday to 14 years in state prison. Mayra Alejandra Gonzalez, 30, -- on probation for a prior DUI -- had a .29% blood-alcohol content when she drove on the wrong side of Camino del Norte Nov. 12, 2018. Her SUV crashed head-on into an oncoming 2011 Jeep Liberty, causing severe injuries -- including a skull fracture and a brain bleed -- to her 9- month-old daughter, who was riding unrestrained. The defendant's 2-year-old daughter suffered facial injuries and her 8-year-old daughter broke a bone. The 57-year-old driver of the other car suffered broken bones and underwent five surgeries to treat his injuries. RELATED: Mother arrested for wrong-way DUI crash that injured childrenDeputy District Attorney Ramona McCarthy told the court at Thursday's sentencing that Gonzalez was drinking throughout the day on Nov. 12 and driving with her kids in her vehicle on a trip that stretched from North San Diego County to East County and back. She crashed into a signpost and a parked car, and backed into a wall prior to the crash that led to her conviction, the prosecutor said. ``She put alcohol and what she wanted to do above the safety of her children and the safety of the community,'' McCarthy told the court. Considering the condition of her then-9-month-old, who still uses a feeding tube to this day as a result of the crash, McCarthy said ``It's a miracle (Gonzalez) is not here on a murder charge.'' RELATED: Mom pleads guilty to Rancho Bernardo DUI crash that injured her daughtersGonzalez was arrested the day after the collision at Palomar Medical Center. At the time of the crash, she was on probation and driving on a suspended license due to a 2017 North County DUI, in which she crashed while pregnant and with at least one of her children riding in the vehicle. She had .23% blood-alcohol content in that case. Gonzalez, who pleaded guilty in August to felony child abuse and drunk driving charges, addressed the court, asking for leniency and the chance to see her family sooner. ``My children are my world, my reason for living,'' said Gonzalez, adding she was ``very, very remorseful'' for the crash. RELATED: Mother of three going to prison for DUI crashShe said she's since taken numerous classes on parenting and alcohol abuse in an attempt to better herself and would never drink and drive again. San Diego County Superior Court Judge Laura W. Halgren said she believed Gonzalez was remorseful for what happened, but said deterring others from making the same mistakes and taking Gonzalez's history of drinking and driving into account factored into imposing a higher sentence. 2860

SAN DIEGO (CNS) - A man accused of carrying out a series of credit union heists in San Diego County, stealing more than ,000 over a three-month span, pleaded not guilty Friday to 10 felony counts, including robbery and attempted robbery.Karl Doron, 43, was arrested Tuesday after he entered the Navy Federal Credit Union, 6755 Mira Mesa Blvd., and allegedly demanded cash from the employees, according to FBI Special Agent Davene Butler.Police officers and FBI agents had been monitoring Doron based on information they had gathered in an investigation that began in late December, when the first robbery occurred, Butler said.Upon leaving the credit union, he was taken into custody without incident and found to be carrying a loaded handgun, the agent said.RELATED: FBI searching for 'Gloved Robber' in series of credit union heistsDeputy District Attorney Andy Aguilar said Doron, whose alleged spree started three days after Christmas, used gloves, glasses, coats and other clothing to mask his identity. He would pass notes to the tellers asking for cash, and was successful on all but two occasions, the prosecutor alleged.Investigators have recovered ,000 Doron allegedly took in his last heist, but ,500 remains outstanding, he said.The defendant faces 14 years and four months in prison if convicted of all counts.Doron's attorney, Deanna L. Lopas, emphasized that none of the holdups her client is alleged to have committed involved violence or threats, simply the passing of a note.She also noted that he has no prior criminal record and holds a doctorate in neuroscience. Doron's LinkedIn page indicates he received his degree from the University of California, Santa Barbara in 2011 and previously served as an Infantry Squad leader in the Marine Corps. His last entry on the LinkedIn page is for work as a postdoctoral scholar at UC San Diego, which ended in January 2015 and involved conducting ``realtime brain-machine interface experiments using electroencephalography.''Doron is being held at San Diego Central Jail in lieu of million bail and is due back in court March 27 for a readiness conference. 2137

SAN DIEGO (CNS) - Elected officials, including Escondido Mayor Sam Abed and San Marcos Mayor Jim Desmond, and a group of residents will urge the San Diego County Board of Supervisors Monday to join the federal government's lawsuit challenging California's sanctuary state law.The bill, signed by Gov. Jerry Brown in October, limits cooperation between California law enforcement and federal immigration authorities. It prohibits local agencies from holding some immigrants on the basis of federal detainers, asking about immigration status or sharing information with federal authorities not available to the public, among other provisions.Opponents believe the law obstructs the deportation of criminals by federal authorities."The sanctuary state law is not only unconstitutional, but it is a real threat to public safety because it forces local government to harbor and shield violent criminals," former San Diego City Councilman Carl DeMaio said. "It is imperative that San Diego voters contact the five members of the Board of Supervisors before the vote tomorrow (Tuesday) to urge them to sign on to the lawsuit against the sanctuary city law."The news conference will be held 11 a.m. at the park behind iHeartMedia, 9660 Granite Ridge Drive.Proponents of the bill, including the ACLU of San Diego and Imperial Counties, believe it makes communities safer and allows local enforcement to focus on their jobs. Supporters say it makes immigrants living in the country illegally more likely to report crimes -- such as domestic violence -- without fear of being detained by federal authorities.Supervisors Dianne Jacob and Kristin Gasper have both indicated in Fox News interviews they support joining the lawsuit against SB 54."This is a politically super-charged issue as you might imagine," Gaspar, a candidate for Congress, told Fox News. "We're talking about hundreds of emails pouring in from all sides. But let us not forget, let's take the emotion out of this. We're talking about following the constitutional laws of our land."The Board of Supervisors will discuss the issue in closed session Tuesday.A group of San Diego business, law enforcement, philanthropic, environmental, faith and social justice figures will hold their own news conference Tuesday urging the board not to join the lawsuit. That event is set for 10 a.m. at the San Diego County Administration Center, Waterfront Park, 1600 Pacific Highway.At 1 p.m. Monday, the group Indivisible San Diego will hold a rally in front of County Supervisor Bill Horn’s Vista office in an effort to convince him to vote against supporting the lawsuit.The group stated, “We must protect our people and our State values. This is our chance to fight for the underserved and underrepresented; our chance to be on the right side of history. And we must demand that Supervisor Horn do what is morally and objectively right, and vote in a manner that reflects the fabrics of our very diverse communities. Supervisor Horn needs to vote AGAINST joining this useless and bigoted Amicus Brief.”“Joining the federal lawsuit is an affront to California values and an attack on the safety and well-being of our communities,” the group added. “As residents of this historically diverse region, we value all residents and acknowledge our interdependence. If immigrants are afraid to call the police and report crimes, we are all less safe. If our local law enforcement agencies use our resources to enforce federal immigration laws, our local priorities are jeopardized. If tax-paying workers are deported, our economy suffers and our tax base declines. The time is now for our collective communities to come together and stand for the civil rights of our most vulnerable residents, our undocumented residents. SB 54 is the law of the land and it should be protected and we will be the ones that protect it.” 3865

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