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Could the no-calorie sweetener you rely on to replace sugar in your diet actually cause weight gain instead of the weight loss you were expecting?The answer may be yes, according to a new study."Artificial sweeteners are not risk-free," said Brian Hoffmann, assistant professor in the Department of Biomedical Engineering at the Medical College of Wisconsin and Marquette University, and a lead author of the study. "They are a very controversial topic when it comes to health and nutrition ... but they're so prevalent in society that I think we owe it to ourselves to try and figure out what's actually going on."Hoffmann presented his new research Sunday at the annual?Experimental Biology meeting in San Diego. Relying on rats and human cell cultures, his team identified a number of pathways linking artificial sweeteners with metabolic changes at the genetic level that could lead to diabetes and obesity. Specifically, the researchers found that three weeks of exposure to aspartame and acesulfame potassium -- two artificial sweeteners frequently combined in products such as Equal -- altered the expression of certain genes responsible for lipid metabolism in the cells of both rats and humans."Aspartame had some significant changes, and one of those was an increase in lipids in the bloodstream and a decrease in a biomolecule that is involved in clearing (lipids) from the bloodstream. And we saw the exact same thing with the acesulfame potassium," Hoffmann said."We then took those particular sweeteners and put them on endothelial cells -- the cells that line the blood vessels and would be exposed to them in the body -- and we detected a marked dysfunction, suggesting why sweeteners and diet soda have been linked to potential cardiovascular problems," he added.What was perhaps most surprising, according to Hoffmann, was that these metabolic changes did not occur in the presence of natural sugars such as glucose and fructose. This suggests that artificial sweeteners could contribute to metabolic disorders such as diabetes and obesity by an entirely different mechanism than natural sugars, he said.Artificial sweeteners appear to contribute to metabolic disorders by altering the activity of certain genes responsible for the breakdown of macromolecules such as fats and proteins, Hoffmann said. This is different from normal sugars, which contribute to cardiovascular disease through insulin resistance and by damaging the cells lining the body's blood vessels."People are generally consuming non-nutritive sweeteners believing they are a 'healthy choice,' but this may not be true," said research scientist Meghan Azad of the University of Manitoba in Winnipeg, who was not involved in the new study."This is especially important given the widespread and increasing consumption of artificial sweeteners in the general population and the increasing use of artificial sweeteners in our food supply," said Azad, who has authored a paper that reviewed a number of studies on the potential downside of artificial sweeteners on weight and health.According to Azad, over 40% of adult Americans consume no-cal sweeteners on a daily basis, and studies that measure the sweeteners in blood and urine show that many people who report not using artificial sweeteners are unknowingly consuming them.It's the latest assault in the ongoing debate over artificial sweeteners and their impact on health -- a debate that began when one of our most popular foods, sugar, turned sour in terms of health. 3527
CLEARWATER, Fla. — Hundreds, maybe thousands, of Trump supporters set sail in Clearwater on Saturday in an attempt to break the world record for the largest boat parade.The goal of the event was to draw more than 1,000 boats to travel from Clearwater Beach to the John's Pass area.Pictures from the event show a massive turnout, though the exact number of boats in attendance isn't yet known. 400

CINCINNATI — Ringed by neurosurgeons in sky-blue scrubs, masks and magnifying loupes, Makenzi Alley lay on a Jewish Hospital operating table and smiled. Her brain glistened pink and purple under the electrode they used to cautiously probe it; sharper implements awaiting their turn in the procedure shone nearby.At Dr. Vincent DiNapoli's signal, Alley began to speak. The team went to work.Wide-awake brain surgery might sound like a nightmare to many, but it was the only way doctors at Jewish Hospital's Brain Tumor Center could remove the tumor that had stolen Alley's sense of taste without damaging the vital tissue nearby."Of all the places to pick, it's kind of right in the spot you wouldn't want it to be," DiNapoli said, gesturing to a scan of Alley's brain in which the tumor stood out as a circular mass of solid white.Even a slight mistake could permanently rob her of her ability to produce spoken or written language — and, if she were fully anesthetized, her team might not know until she woke up."I knew he needed me to talk to do his best job, so I talked the whole time," Alley said months later, laughing. "There was never a time where I was like, ‘We need to stop,' and I started freaking out. It was very smooth. Very simple."DiNapoli's team used the electrode, her scans and her ongoing conversation as mapping tools. When she stopped talking, they knew they had touched the Broca area — the region of the brain that controls speech production — and needed to proceed carefully.The tumor they removed from Alley's brain was the size of a golf ball, she said. With it went the stutter she had developed as it pressed on her speech center; in its absence, her sense of taste returned.She was also able to return to the pastimes she loves, including playing guitar, studying and running competitively."That was actually an emotional sight to me," her mother, Traci Alley, said Thursday. She cradled her phone in her hand, displaying a picture of Alley smiling midway through a race. "She did so well. I wasn't sure I'd see her running again." 2095
COLORADO SPRINGS — The COVID-19 pandemic continues to make an impact, especially to agencies who help kids who've been removed from their families because of abuse or neglect.One foster care agency in Colorado, Hope and Home, says they have over two hundred foster families with 80 recently licensed. Despite the pandemic, the organization says families are continuing to foster children and they haven't seen a decrease in interest."We are always on standby and ready to take care of kids when they come into care. They're always a need for foster families, but there's a greater need during the pandemic," said Jacquelyn Thurman- Wright. "With kids not being at school, they are not in the line of sight of teachers who are mandatory reporters. Sometimes we're seeing this abuse go on because these kids are flying under the radar and not being seen."The organization says COVID-19 has had a huge impact on the foster care system."The most obvious and immediate impact on Hope and Home is that we had to suspend in-person support groups because on a given night we could have 250 people in the building. But within a week, we were up and running on Zoom and Facebook live," said Thurman- Wright.Right now, Hope and Home is fully online and virtual but they're still taking inquiry phone calls and placing kids in foster homes.Sean and Mandy have been fostering since 2018 and didn't let the pandemic get in their way of adopting triplets and fostering a newborn baby."We didn't go to the courthouse because of COVID. So we had it on our couch via ZOOM with the judge," said Mandy.The couple says the pandemic hasn't made fostering easy."Visits are a lot harder, they're more virtual unless they're younger and that its really hard. Therapies, a lot of foster kids come in needing therapies and they're usually virtual," said Mandy.With the new restrictions, doctor visits are harder as well."So if one of the triplets have an appointment, even though they're triplets we can't bring the other two. We actually hired a nanny because of it," said Mandy and Sean.Even with the pandemic, it was not only important for Sean and Mandy but their children, that they continue fostering."We felt like this is what we had to do and then when we were getting our other foster baby. We sat down and said maybe we have to because we all felt drawn to them," said Calvin.This article was written by Mayo Davison for KOAA. 2417
Corporate America is coming to Wall Street's rescue.The Dow soared?548 points, or 2.2%, on Tuesday as investors cheered fat profits from major companies and relative calm in the bond market. The huge rally, the Dow's best day since March, helped the index recover a chunk of last week's hefty losses.Tech stocks, the biggest losers during the market turmoil, raced back to life. The Nasdaq spiked nearly 3%, while the S&P 500 advanced 2.2%.Investors piled back into tech darlings. Amazon, Facebook and Netflix closed sharply higher."It's a bounce back after an overdone situation last week," said David Joy, chief market strategist at Ameriprise Financial.Market sentiment was lifted by earnings beats from Goldman Sachs, Morgan Stanley and Johnson & Johnson. Adobe and UnitedHealth added to the good news by offering upbeat guidance for 2019.Taken together, the corporate report cards underscore the ability of businesses to cash in on the strong US economy. And the results should ease fears about the US-China trade war."We're focusing back on fundamentals," said Dan Suzuki, portfolio strategist at Richard Bernstein Advisors. Suzuki called Tuesday's rally a "reflexive rebound."Last week, the Dow, S&P 500 and Nasdaq all suffered their worst week since March. At one point, the Dow plummeted more than 1,000 points in just two trading days.Despite Tuesday's advance, all three major indexes remain firmly in the red for the month.One major source of investor nervousness has improved: bond yields. A sudden spike in 10-year Treasury rates above 3.25% spooked markets. The rapid climb in rates was driven by the strong economy, the surging federal deficit?and concerns about a more aggressive Federal Reserve.Investors feared higher borrowing costs that could slow growth and sudden competition for the stock market from boring bonds.But Treasury rates, which move in the opposite direction of prices, eased late last week as investors poured cash into the safety of government bonds. Rates have stabilized at around 3.15%, relieving stock market bulls."That has reassured people that this is not the start of something much worse that could really sidetrack the market," said Bruce McCain, chief investment strategist at Key Private Bank. 2288
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