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HONG KONG, July 19 (Xinhua) -- A gene controlled by male hormone was critical for the growth of liver tumor, leading to a higher incidence of the disease in men than in women, according to the Chinese University of Hong Kong which made the results public on Tuesday.There is a significant gender bias in liver cancer incidence. In Hong Kong, men are three times more likely to develop liver cancer than women. Such phenomenon prompted researchers from the university to carry out a genomic location analysis in liver cancer cells starting from 2008.The researchers discovered, out of 17,000 human genes, that a gene called Cell Cycle-Related Kinase (CCRK) was directly controlled by androgen receptor. They further found that CCRK was critical for the induction of signaling pathway leading to abnormal liver cell growth and tumor formation.The results also reveal that 70 percent of patients with liver cancer were found to produce high levels of CCRK. More importantly, these patients were more likely to have late-stage cancers and lived shorter than those with low CCRK level.Using mouse models, the researchers found that either lowering the level or blocking the signaling pathway of CCRK in liver cancer cells could significantly reduce the tumor growth rate.The study has validated that CCRK is an important gene that has potential to cause liver cancer and the gene can be tested as a new targeted therapy in future.Vice-Chancellor of the university Joseph Sung, who is also team leader of the research project, said the results explained why men have a higher risk of liver cancer than women and helped push ahead with the development of a novel treatment of the disease.The above study results were published online in July in Journal of Clinical Investigation.

BEIJING, July 11 (Xinhuanet) -- Gay and bisexual men account for around one in every three new cases of HIV in China, according to the latest official statistics released by the Ministry of Health.About 5 percent of the group - officially termed men who have sex with men, or MSM - are living with the virus, which is a rate that is 88 times higher than the national HIV prevalence rate of 0.057 percent.The problem is particularly acute in large urban centers, with the prevalence rate in some southwestern cities reaching almost 20 percent.However, the statistics also show that less than half of all gay and bisexual men have access to HIV screening, while about 15 percent of those who are infected are not receiving treatment."Cities are at the heart of China's development and progress and must remain at the forefront of its HIV response," said Michel Sidibe, executive director of the Joint United Nations Programme on HIV/AIDS (UNAIDS), during a workshop about the HIV impact on MSM on Saturday in Chengdu, capital of Southwest China's Sichuan province."Through bold action cities can lead the way to achieving the UNAIDS vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths," he said, according to a UNAIDS news release. "We hope that over the next year, many more Chinese cities will implement MSM strategies."Almost 10 percent of gay and bisexual men in Chengdu are HIV-positive, according to Yang Xiaoguang, director of the city's health bureau. He agreed with Sidibe that cities have a crucial role to play in AIDS prevention and added: "By working to build a strong, multi-sector response in Chengdu, with meaningful community participation, we can scale-up coverage of prevention, treatment and care services among MSM and halt the spread of HIV."During the workshop, senior Chinese health officials, representatives from civil societies and other delegates discussed a new five-year strategy that increases coverage of HIV prevention and treatment for the MSM population and promotes the participation of community organizations.Government estimates put China's population of gay men at between 5 and 10 million, although Zhang Beichuan, a leading expert on HIV at Qingdao University, puts the number closer to 30 million.Tong Ge, coordinator of China's MSM Health Forum, noted the importance of ensuring strong cooperation between the government and society."By building on the experiences of cities like Chengdu, which already have well developed AIDS responses, we can help promote multi-sector collaboration on an equal, orderly basis and strengthen the response to HIV nationwide," he said. "The next step will be to implement similar strategies in other cities nationwide."Chengdu's new strategy underscores the critical role community organizations can play in reaching MSM and other populations at a higher risk of infection, experts at the workshop said.In 2009, China had an estimated 740,000 people living with HIV/AIDS, according to UNAIDS statistics.

WASHINGTON, Aug. 4 (Xinhua) -- U.S. scientists have found two gene mutations occurring in oligodendrogliomas, the second-most common form of brain cancer, according to a study to be published Friday in journal Science.For years scientists have been looking for the primary cancer genes involved in oligodendrogliomas evolvement. Scientists know the two chromosomes held the probable mutations, but the particular gene information remains unclear.Now scientists at Duke University Medical Center and Johns Hopkins University have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19.The genes they identified, CIC or FUBP1, are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, said Hai Yan, a Duke associate professor of pathology and co-corresponding author of the study.The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas. They found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.These genes were difficult to find until the technology improved, said Yan."The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist both in reducing the chance of relapsing and increasing odds of success.

BEIJING, Aug. 26 (Xinhua) -- China's maritime authority on Friday once again urged U.S. oil giant ConocoPhillips to finish cleaning up oil spills in north China's Bohai Bay as soon as possible.Aug. 31 is the deadline set by the government. "There are only five days to go before the arrival of the deadline," said a statement of the State Oceanic Administration (SOA).The SOA urged ConocoPhillips China to adopt all technical measures that could be used to clean up oil spills, and to do it "with an active manner."Liu Cigui, head of the SOA, said Thursday that his administration is collecting evidence and gauging the ecological impact of the spills in preparation for possible legal action against the company.ConocoPhillips China, a subsidiary of ConocoPhillips, first reported the oil spills in June. The spills have spread to beaches in Hebei and Liaoning provinces and been blamed for losses in local tourism and aquatic farming industries.Although the company has worked to clean up the spills, pollutants have still been found in the bay, even after cleanup efforts were reported to be complete.ConocoPhillips China admitted that a total of 16 oil spill sources have been found in the bay as of Friday.

BEIJING, Sept. 9 (Xinhua) -- Lenovo Group, China's largest PC maker, said it aims to become the world's second-largest PC provider by the end of this year, China Daily reported Friday.The PC maker will take aggressive action to expand in the international PC market left by its competitors because of strategy adjustment, the English newspaper quoted Liu Chuanzhi, the board chairman of Lenovo, as saying.A few weeks ago, the world's biggest PC maker Hewlett-Packard Corp. said it will spin off its PC sector. Apple Inc's former CEO Steve Jobs resigned."The Chinese market is the starting point for Lenovo, but it won't be the only place Lenovo should put emphasis on. We will set up a more active strategy for expanding in overseas markets," Liu said.The PC maker has long been focusing on the global market. It purchased the PC division of the IBM Corp. a few years ago. In January, it announced a 175-million-U.S.-dollar joint venture with Japan's NEC Corp. In July, Lenovo completed its acquisition of Medion AG, a German multimedia and consumer electronics maker.

来源：资阳报