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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789
SAN DIEGO (CNS) - A woman robbed a San Diego vape and smoke shop at gunpoint and was later arrested, authorities said Saturday.It happened just before 10 p.m. Friday at the shop at 3094 National Avenue, according to San Diego police Officer Robert Heims.The woman walked in, pointed a gun at an employee and demanded money, Heims said. She took an unknown amount of money and fled eastbound on National Avenue.Officers located the suspect a few hours later near South 32nd Street and arrested her, he said.The suspect was identified as Jeanette Sarmiento, 37, Heims said. 579

SAN DIEGO (CNS) - A man accused of ambushing a janitorial worker at a Little Italy coffee shop and trying to sexually assault her pleaded not guilty Wednesday to a half-dozen felony charges, including kidnapping with the intent to commit a sex offense.Christopher Merron, 28, was ordered held on million bail. He faces life in prison if convicted, said Deputy District Attorney Nicole Roth.Merron allegedly attacked the woman as she was cleaning the coffee shop in the 1700 block of India Street about 4:30 a.m. last Sunday, pushing her into a back room, taking her car keys and threatening her with a knife.Following a struggle, the victim, whose name was withheld, was able to break free and run out of the building, said San Diego police Lt. Jason Weeden.RELATED: Man tries to sexually assault woman before stealing her carThe assailant then fled in the woman's tan 1998 GMC Jimmy SUV.Merron was arrested in Mission Valley the next day and the victim's stolen SUV was recovered, Weeden said."This was a brazen and serious sex crime," Roth said outside court. "This was a traumatic event."RELATED: Arrest made in Little Italy attempted sex assault, vehicle theftBesides kidnapping with the intent to commit a sex offense, Merron is charged with assault with the intent to commit a sex offense, attempted oral copulation, false imprisonment with force, robbery and auto theft.Merron will be back in court Oct. 26 for a readiness conference and Oct. 30 for a preliminary hearing.While living in Virginia, Merron pled guilty to accessory to robbery, resisting arrest and several drug charges. 1602
SAN DIEGO (CNS) - Live Nation Friday announced a multi-year agreement with North Island Credit Union for the naming rights of the Chula Vista venue formerly known as the Mattress Firm Amphitheatre.The two companies plan to work together to improve the venue experience for concertgoers with giveaways and prizes, Live Nation said in a statement. Representatives from North Island Credit Union will also be on-site during the concert season from April to October to maintain engagement with 497
SAN DIEGO (CNS) - A Lemon Grove man who aimed a laser pointer at a San Diego police helicopter during a police protest this summer is facing a maximum possible sentence of five years in prison following his conviction by a federal jury, the U.S. Attorney's Office said Thursday.Rudy Alvarez, 25, was found guilty by a jury in San Diego federal court late Wednesday for shining a laser at the SDPD chopper around 8:30 p.m. June 4 in the area of 500 University Ave.The U.S. Attorney's Office said Alvarez shined the laser at the chopper multiple times over the course of an hour as he marched with protesters through downtown San Diego.The count of aiming a laser pointer at an aircraft carries a maximum possible sentence of five years in prison and a 0,000 fine. Sentencing is scheduled for Feb. 22.U.S. Attorney Robert Brewer called the result "a very important verdict" and said "This kind of crime could have a disastrous impact if a pilot's sight is compromised. We support the Constitutional rights of free speech and assembly, but the rule of law must be respected. It's there for a reason -- to protect the public and law enforcement from danger."Earlier this year, the U.S. Attorney's Office also charged San Diego resident Stephen Glenn McLeod with the same count for allegedly directing a laser at a San Diego Police Department chopper multiple times during a protest on Aug. 28. His case remains pending with a trial-setting hearing slated for Dec. 18. 1474
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