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2025-06-04 09:37:27
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  昌吉好点的医院不要孩子   

SAN DIEGO (KGTV) — When you are out in public, it is virtually impossible to tell who has immunity to the coronavirus and who is susceptible.A San Diego-based company is trying to change that by developing two new COVID-19 monitoring systems that are as easy as checking someone’s forearm.Diomics is developing a device that looks like a nicotine patch that the company says can reveal the presence of SARS-CoV-2 antibodies in 24 to 36 hours. The patch is intended to be worn for one to two weeks, offering people a way to monitor -- and potentially display -- their infection status, according to CEO Anthony Zolezzi.When the patch, named Diocheck, detects antibodies circulating in the blood, it turns red.“We think this is an integral piece of getting things back to normal,” Zolezzi said. “This can get the country back operating and get us comfortable that the people around us aren’t infected.”A second device, made from thousands of tiny polymer beads, can be injected into the skin and offer COVID monitoring for six months to a year, Zolezzi said. The company is still testing how long the test can stay active before it’s safely absorbed by the body.The company plans to launch clinical trials at UC Irvine next month.Zolezzi envisions the tests would be useful for employees in numerous sectors, including the airline industry, the cruise industry, the gambling industry and the military, offering a new way to detect and rapidly quarantine infected individuals.Once a coronavirus vaccine is released, the tests could be a useful companion, he said, since it will likely take several weeks to develop protective antibodies after inoculation. An individual wearing the patch, for example, could find out when they have antibodies circulating in the blood.The tests could also show when a person begins to lose antibodies. Studies have show individuals with a mild coronavirus infection lose antibodies after a few months, and it’s common for vaccines to require multiple doses.“This patch will show you, when the color dissipates, it’s because your antibodies have dissipated,” Zolezzi said. “That’s the time when you need to get a boost, or some type of prophylaxis.”The small biotech firm with less than 20 employees is leveraging technology that’s more than 100 years old.In 1907, a French physician named Charles Mantoux developed an injection test for tuberculosis that produces a raised, red dot on the skin when the bacteria is detected. This is the standard test given today.“All we’re doing is modernizing it,” Zolezzi said. The company’s patented slow-release material allows for much longer monitoring, he added.Diomics was making skin care, wound care and diabetes products before the pandemic shifted the company’s focus. Their components are FDA approved individually, but will need new approval for this use, Zolezzi said.Zolezzi said production is underway, but the company is hoping to partner with a large drugmaker to rapidly scale up manufacturing. Their goal is to have products on the market by the end of the year. 3055

  昌吉好点的医院不要孩子   

SAN DIEGO (KGTV) -- We’ve known for a while that COVID-19 hits people over 65 especially hard, but a study published Wednesday from researchers in San Diego offers new insight into why that happens.The numbers are staggering: if you’re 65 or older, your risk of winding up in the hospital from COVID-19 is five to 11 times higher than someone under 30. Your risk of death is at least 90 times higher, according to data from the Centers for Disease Control and Prevention.Researchers at the La Jolla Institute for Immunology say the reason why older people fare so much worse appears to be from a lack of T-cells, a type of white blood cell that can decline with age.“Some viruses get controlled by one part of the immune system. Some viruses get controlled by another. In this case it seems that T-cells really do a lot of the work,” said Dr. Shane Crotty, one of the authors of the study published Wednesday in the journal Cell.Dr. Crotty and his colleagues looked at 50 people infected with the virus, and they measured the three elements of the adaptive immune system in detail: antibodies, helper T-cells and killer T-cells.Then they compared the measurements to how people fared against the virus. Some patients in the study group had severe cases, others had mild infections.The researchers found that people with all three branches of the adaptive immune system tended to fully recover. People with severe cases of the virus often lacked one or more of the immune branches, and it was particularly evident in older people.“Our data indicated that of the older individuals, it was particularly the ones that had fewer T-cells to start that look like they really struggled to control this virus,” Dr. Crotty said.As we age, we have fewer T-cells to send after invading pathogens. “That collection of T-cells gets smaller. So it’s harder to recognize a new virus,” Crotty said.Among the 748 deaths in San Diego County reported as of Wednesday, 87% were people aged 60 and older.The findings from LJI may have implications in the search for a vaccine against COVID-19. The data suggests that vaccine-makers may want to target a drug that elicits all three branches of the immune response, Dr. Crotty said. Some vaccine approaches, such as inactivated virus vaccines, only elicit two of three branches, not killer T-cells. However, Crotty said it was too soon to rule any candidates. Two strong branches produced by a vaccine could potentially cover for the lack of a third, he said.Crotty said the findings could help vaccine-makers interpret results from the clinical trials and find the right dosing.“Is a given vaccine a good vaccine, and you just need a booster immunization?” he said. “Does it work well in one population but it doesn’t help in the elderly because it doesn’t generate a T-cell response, for example? Those are the scenarios when this type of knowledge will come into play.” 2906

  昌吉好点的医院不要孩子   

SAN DIEGO (KGTV) — Two tropical storms bearing down on the Eastern Pacific have forced a Norwegian Bliss cruise ship to abandon its original route and stop in San Diego.The stopover for the cruise ship came just before 7 a.m. Wednesday. The ship was originally scheduled to sail from Los Angeles to several ports in Mexico but was forced to change that route due to tropical storms Willa and Vicente.The new route has the cruise ship heading for San Francisco to San Diego to Ensenada, Mexico. The ship is scheduled to depart from San Diego at 6 p.m. Wednesday.Norwegian Cruise Line said in a statement that guests were alerted to the modified itinerary as soon as possible."Due to Hurricane Willa and Tropical Storm Vincente in the Eastern Pacific, we modified Norwegian Bliss’ itinerary from Los Angeles," the cruise line said. "Our onboard team is working to ensure the best vacation experience possible given these weather-related changes."Tropical storm Willa was downgraded from a Category 5 Hurricane Wednesday, but still made landfall with maximum sustained winds of 120 mph. Vicente was due to follow Willa moving inland over Mexico.RELATED: Cruise industry booming as season begins in San DiegoThe Norwegian Bliss is one of Norwegian Cruise Line's newest vessels in service. The ship can hold more than 4,000 guests, 1,700 crew members, and includes an aqua park, laser tag arena, casino, and a two-level race track — the first for a North American-based ship.Each port of call has an approximate 0,000 impact in San Diego, according to port officials. The port expects 92 ships to dock in San Diego this year, bringing more than 295,000 passengers to town. 1698

  

SAN DIEGO (KGTV) -- Tracking citizen complaints about law enforcement is a requirement of California law. However, some say there needs to be a significant improvement in that process."Police officers have tremendous authority," said former police officer and criminal justice professor Kevin LaChapelle. He broke down how the process works."[In] a formal complaint, there should be written documentation and the agency is accountable for reporting that to the Department of Justice," LaChapelle said. LaChapelle says the formal complaint process differs from an informal complaint, where someone may talk to an officer or supervisor but no documentation is required. Those interactions are not included in DOJ numbers. When it comes to two of the largest departments in the county, Team 10 found the number of complaints differ drastically. In 2018, the San Diego Sheriff's Department reported nine complaints. In 2017, there were six reported complaints.San Diego Police Department reported 74 complaints last year. In 2017, there were 97 reported to the DOJ.Each department reports to the state both substantiated and unsubstantiated complaints. 1156

  

SAN DIEGO (KGTV) — Two new studies published this week suggest people with blood type O have a lower likelihood of catching COVID-19 and developing severe illness than people with other blood types.Blood type is a characteristic we inherit from our parents and there are four major blood groups: A, B, AB and O.Danish researchers looked at nearly 500,000 people who tested positive for COVID-19 and found that people with type O were underrepresented.In a study published in the journal Blood Advances, the researchers found 38.4 percent of those infected had type O when that type actually makes up 41.7 percent of the population in that area.The researchers say the findings suggest people with type O are less likely to get infected in the first place.On the other hand, the team found that people with type A blood were overrepresented: 44.4 percent of those infected had type A compared to an expected value of 42.4 percent. The researchers suggest people with type A might be more at risk.Another study, also published in Blood Advances, looked at 95 critically ill patients in Canada. They found people with type O or type B blood tended to have a shorter stay in the intensive care unit, an average of nine days for those blood types compared to 13.5 days for people with type A or AB.They also reported that people with type O or type B were less likely to need a ventilator, with 61 percent of cases requiring mechanical ventilation compared to 84 percent for people with blood type A or AB.“Yes, there may be some of these associations. I don't think it's fully understood at this point,” said Dr. Christian Ramers of Family Health Centers of San Diego, who was not involved in the studies.The science on COVID-19 risk and blood type is mixed. These two new studies align closely with a previous study in China and another in Europe, but a third study in the U.S. found no significant link between severe COVID cases and blood type.At this point, doctors aren’t sure why blood type might affect outcomes with the disease, but there are several theories.“The immune system is an incredibly mysterious and complicated thing that we don't fully understand,” Ramers said. “Blood type sort of plays into that because people with different blood types actually have slightly different immune systems and immune responses.”Your blood type impacts the kind of antibodies you produce. That is why it is so important in blood transfusions to get the right blood type; blood from the wrong donor can trigger antibodies that attack those red blood cells.People with blood type O have two sets of antibodies, known as anti-A antibody and anti-B antibody. People with type A or B only have one or the other.Researchers in the Canadian study hypothesized that the anti-A antibody in particular may help control the coronavirus. People with blood type O and blood type B produce this kind of antibody. Individuals with type A or type AB do not.People with blood type O also have characteristics that make them less prone to issues with blood clotting, a major issue in severe cases of COVID-19.Experts say that if type O blood is protective against the virus, it’s not by a large amount.And this protective benefit doesn’t extend to all pathogens. Past studies have shown people with type O are more at risk from a type of bacteria that can cause ulcers and cholera. 3369

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