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Several authors of a large study that raised safety concerns about malaria drugs for coronavirus patients have retracted the report. They say independent reviewers weren't able to verify information that’s been widely questioned by other scientists. Thursday’s retraction in the journal Lancet involved a report on hydroxychloroquine and chloroquine, drugs long used for preventing or treating malaria but whose safety and effectiveness for COVID-19 are unknown.The study linked the drugs to a higher risk of death or heart problems. The study leaders also retracted an earlier report using the same company’s database on blood pressure drugs published by the New England Journal of Medicine. 700
Special counsel Robert Mueller's team could reveal tantalizing new details in its investigation into possible Russian collusion on Friday thanks to a pair of court filing deadlines involving President Donald Trump's former campaign chairman Paul Manafort and former lawyer Michael Cohen.Mueller's office has a Friday deadline to explain to the court why it accused Manafort of lying to investigators and breaking his cooperation deal. Separately, the special counsel's office and federal prosecutors in New York have to provide memos to recommend a sentence for Cohen -- filings that are expected to detail how he has cooperated in multiple investigations.The memos from Mueller come the same week that the special counsel's office said in court Tuesday that former Trump national security adviser Michael Flynn provided "substantial assistance" to the special counsel's office and should not receive jail time.In addition, former FBI Director James Comey is testifying behind closed doors on Friday before the House Judiciary and Oversight committees for a Republican-led probe into the origins of the FBI's Russia investigation. Also Friday, George Papadopoulos -- the first person to plead guilty in the Mueller probe -- is being released from prison after serving a two-week sentence.It all adds up to one of the busiest weeks in the 19-month Mueller investigation -- and potentially one of the most revealing. 1428
SORRENTO VALLEY, Calif. (KGTV) - Another San Diego-based company is moving forward on developing a vaccine for the coronavirus. Sorrento Therapeutics is working on several projects that they believe could lead to viable vaccines or treatments. One of them was announced on Monday. Sorrento Therapeutics said it was partnering with Boston-based Smartpharm to create a gene-encoded antibody vaccine. “In the effort to more quickly resolve the global COVID-19 crisis, our company has initiated a rapidly accelerated program for the identification of potent neutralizing antibodies against SARS-CoV-2 coronavirus antigens that may be used for either treatment or prophylaxis,” said Henry Ji, CEO of Sorrento Therapeutics. Sorrento Therapeutics is also working on another vaccine called the I-Cell project. That vaccine uses a decoy virus to activate a person’s immune system to train it to attack the real virus. It’s also developing a protein called COVIDTRAP that can bind to the receptors on the coronavirus, thus blocking it from being able to bind to the receptors on healthy human cells. If proven succesful, it could be used as a treatment or preventative measure.How long will it take for them to be ready?“That all depends on what leeway the FDA gives us,” said Mark Brunswick, Senior Vice President of Regulatory Affairs at Sorrento Therapeutics. If they can get fast tracked, he estimates they can start clinical trials in 2 months, as opposed to 9-12 months normally. 1483
Some people are returning to work after months of being at home. It's a big change for people and pets as well.Veterinarians warn pets who haven't experienced separation anxiety before could still be at risk of having it now.Many have gotten used to a new routine of having humans at home.Other dogs may be more prone to this anxiety if they already suffer from other types of it, like when there's a thunderstorm or loud noises.“It’s similar to people having general anxiety and being higher strung,” said Dr. Jessica Romine, an internist with Blue Pearl Veterinary Partners. “So, if you notice that your dog tends to have a really strong reaction to storms, that could be a warning sign that they may also have that.”Some other signs include your pet not being able to separate themselves from you when you go to other rooms in the house.If they damage things at home whenever you're away for short periods of time, Romine says they’re not angry, they’re panicked.If you're headed back to work soon, a few things you can do to ease their anxiety is practice going away for a while, practice crate training. When you return home, try not to make a big deal out of it.“It’s a completely natural instinct to greet our dogs that are just thrilled to see us,” said Romine. “We're just as thrilled to see them and coo over them, but that really just makes it a huge highlight when you leave and come back, so the general recommendation when you leave and come back is to greet them briefly and then try and let them calm down.”Reward calm behavior. Sometimes medication may help. Talk to your veterinarian about this. 1621
Some bars will close for two weeks starting Tuesday under a new decision by Governor Andy Beshear's office.Starting Tuesday at 5 p.m., freestanding bars will close and restaurants will be limited to 25% capacity indoors. Outside seating can remain as long as social distancing measures are in place.This will be in effect for two weeks, until August 11.During the COVID-19 briefing, Gov. Beshear also recommended that schools across Kentucky should postpone in-person instruction until the third week in August.WLEX's Jordan Mickle was first to report this story. 571