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BEIJING, June 27 (Xinhuanet) -- A "lean gene" that helps people keep slim was found closely related to diabetes and heart disease, according to a study pulished in Nature Genetics journal on Sunday.The scientists from Britain’s Medical Research Council Epidemiology Unit conducted the study.After comparing the genetic codes of more than 75,000 people, a gene called IRS1 was spotted as the decisive factor to lower the fat level in human body.But in further study, IRS1 was found putting people to a 20 percent higher risk of developing heart disease and type-2 diabetes.The study warned that people who appear slim and fit might be also at risk.But scientists suggest that the study results did not change the general message for most people."While this study pointed to genes as one factor in determining the risk of developing these conditions, it was important to remember that lifestyle factors like diet, exercise, cutting out smoking and maintaining a healthy weight also play a vital role in reducing the risk," said Ruth Loos, who led the study.

WASHINGTON, Sept. 12 (Xinhua) -- An enzyme that appears to play a role in controlling the brain's response to nicotine and alcohol in mice might be a promising target for a drug that simultaneously would treat nicotine addiction and alcohol abuse in people, U.S. researchers find.Over the course of four weeks, mice genetically engineered to lack the gene for protein kinase C (PKC) epsilon consumed less of a nicotine-containing water solution than normal mice, and were less likely to return to a chamber in which they had been given nicotine. In contrast, normal mice steadily increased their consumption of nicotine solution while the mice lacking PKC epsilon did not.The study conducted by researchers at the Ernest Gallo Clinic and Research Center, affiliated with the University of California, San Francisco, appeared Monday in the online edition of the Proceedings of the National Academy of Sciences.In normal mice, as in humans, nicotine binds to a certain class of nicotinic receptors located on dopamine neurons, which causes dopamine to be released in the brain. Dopamine creates a feeling of enjoyment, and thus prompts a sense of reward. Researchers found that mice lacking PKC epsilon are deficient in these nicotinic receptors.The finding complements earlier research in which researchers found that mice genetically engineered to lack the PKC epsilon enzyme drank less alcohol than normal mice and were disinclined to return to a chamber in which they had been given alcohol."This could mean that these mice might not get the same sense of reward from nicotine or alcohol," said Gallo senior associate director and investigator Robert Messing. "The enzyme looks like it regulates the part of the reward system that involves these nicotinic receptors."The reward system is a complex of areas in the brain that affect craving for nicotine, alcohol and other addictive substances.The next step in the research, said Messing, would be to develop compounds that inhibit PKC epsilon. The ultimate goal, he added, would be medications that could be used "to take the edge off of addiction by helping people get over some of their reward craving."

CANBERRA, Sept. 9 (Xinhua) -- Managing other people at work triggers structural changes in the brain, protecting its memory and learning center well into old age, Australia's study revealed on Friday.Australia's University of New South Wales (UNSW) researchers have, for the first time, identified a clear link between managerial experience throughout a person's working life, and the integrity and larger size of an individual's hippocampus (the area of the brain responsible for learning and memory) at the age of 80. "We found a clear relationship between the number of employees a person may have supervised or been responsible for and the size of the hippocampus," Dr Michael Valenzuela, Leader of Regenerative Neuroscience in UNSW's School of Psychiatry, said in a statement released on Friday."This could be linked to the unique mental demands of managing people, which requires continuous problem solving, short term memory and a lot of emotional intelligence, such as the ability to put yourself in another person's shoes. Over time this could translate into the structural brain changes we observed."The findings confirmed that staying mentally active promotes brain health, potentially warding off neurodegenerative diseases such as Alzheimer's.Using MRI imagery in a cohort of 75-92 year-olds, researchers found larger hippocampal volumes in those with managerial experience compared to those without. The effect was also seen in women who had taken on managerial roles in nursing or teaching, for example.The study was presented at this week's Brain Sciences UNSW symposium Brain Plasticity The Adaptable Brain, held in Australia.

WASHINGTON, Sept. 27 (Xinhua) -- At least 13 people had been killed amid 72 sickened in 18 states in listeria outbreak traced to Colorado cantaloupes, making it the most deadly U.S. outbreak of food-borne infection since 1998, the Centers for Disease Control and Prevention (CDC) said Tuesday in a statement posted on its website.Of the 13 deaths, four were in New Mexico, two were in Colorado, two were in Texas, and there was one each in Kansas, Maryland, Missouri, Nebraska and Oklahoma.Victims range in age from 35 to 96 years, with an average age of 78. All of the illnesses started on or after July 31.The figures were the latest confirmed as of Monday morning, according to the CDC. But they may well rise in the still-widening outbreak as state and local officials are investigating three additional deaths that may be connected.In 1998, 21 people died from listeria linked to tainted hot dogs, according to a CDC online database.The Food and Drug Administration on Sept. 14 warned consumers not to eat cantaloupes from Colorado's Rocky Ford region shipped by Jensen Farms. The cantaloupes with the brand name Rocky Ford were distributed from July 29 to Sept. 10 in at least 17 states.Listeria is a common bacterium that typically causes mild illness in healthy people, but can cause severe illness in older people and those with compromised immune systems. It also can cause miscarriages and stillbirths in pregnant women and severe infections in new babies.Listeria infections lead to about 1,600 serious illnesses each year and about 260 people die, according to the CDC.The CDC estimates that about 48 million people in the U.S. each year get sick from tainted food, with about 128,000 hospitalized and 3,000 deaths.

BERLIN, June 14 (Xinhua) -- A two-year-old boy became the first child to be killed by the deadly E. coli in Germany on Tuesday, officials said.To date, the terrifying EHEC infection has claimed 36 lives in Germany and one in Sweden.The child, from the northern town of Celle, died in hospital in Hanover of kidney failure and abnormal breakdown of red blood cells, two extreme symptoms of the infection with enterohaemorrhagic E. coli (EHEC), authorities in the state of Lower Saxony said.The boy became the youngest known fatal victim since the outbreak of E. coli in May. His father and 10-year-old brother were also infected with the deadly bacteria, but are recovering, doctors told a local newspaper.The Robert Koch Institute, Germany's national disease prevention and control agency, said on Tuesday that a total of 3, 235 cases had been reported in the country. Among them, 782 people are suffering from haemolytic uraemic syndrome (HUS), a life- threatening illness arising from E. coli, which would destroy human kidney and nervous system.The institute added that the number of new infections is declining sharply in recent days, with only seven reported on Tuesday.German authorities announced on Friday that bean sprouts from a farm in northern Germany were one source of the outbreak, and dropped the previous warning against eating raw cucumbers, tomatoes and lettuce. However, the food panic has caused losses worth hundreds of millions of dollars for European farmers.

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