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WASHINGTON, July 13 (Xinhua) -- Human neural stem cells are capable of helping people regain learning and memory abilities lost due to radiation treatment for brain tumors, a University of California, Irvine (UCI) study suggests.Research with rats found that stem cells transplanted two days after cranial irradiation restored cognitive function, as measured in one- and four-month assessments. In contrast, irradiated rats not treated with stem cells showed no cognitive improvement."Our findings provide solid evidence that such cells can be used to reverse radiation-induced damage of healthy tissue in the brain," said Charles Limoli, a UCI radiation oncology professor.Study results will appear Friday in Cancer Research, a journal of the American Association for Cancer Research.Radiotherapy for brain tumors is limited by how well the surrounding tissue tolerates it. Patients receiving radiation at effective levels suffer varying degrees of learning and memory loss that can adversely affect their quality of life."In almost every instance, people experience severe cognitive impairment that's progressive and debilitating," Limoli said. " Pediatric cancer patients can experience a drop of up to three IQ points per year."For the UCI study, multipotent human neural stem cells were transplanted into the brains of rats that had undergone radiation treatment. They migrated throughout the hippocampus -- a region known for the growth of new neurons -- and developed into brain cells.Researchers assessed the rats one month and four months after transplantation, noting enhanced learning and memory abilities at both intervals.Additionally, they found that transplanting as few as 100,000 human neural stem cells was sufficient to improve cognition after cranial irradiation. Of cells surviving the process, about 15 percent turned into new neurons, while another 45 percent became astrocytes and oligodendrocytes -- cells that support cerebral neurons.Most notably, Limoli said, he and his colleagues discovered that about 11 percent of the engrafted cells expressed a behaviorally induced marker of learning, indicating the functional integration of those cells into memory circuits in the hippocampus."This research suggests that stem cell therapies may one day be implemented in the clinic to provide relief to patients suffering from cognitive impairments incurred as a result of their cancer treatments," Limoli said.
SAN FRANCISCO, Sept. 22 (Xinhua) -- Former eBay Chief Executive Officer and California governor candidate Meg Whitman on Thursday was named Hewlett-Packard's new CEO, replacing Leo Apotheker who served 11 months on the job."We are fortunate to have someone of Meg Whitman's caliber and experience step up to lead HP," said the California-based company in a statement."We are at a critical moment and we need renewed leadership to successfully implement our strategy and take advantage of the market opportunities ahead," said the troubled tech giant.It noted that the job of the HP CEO now requires additional attributes to successfully execute on the company's strategy, adding Whitman "has the right operational and communication skills and leadership abilities to deliver improved execution and financial performance.""I am honored and excited to lead HP. I believe HP matters -- it matters to Silicon Valley, California, the country and the world," said Whitman in a statement.Whitman, 55, joined the HP board in January and served as president and CEO of eBay from 1998 to 2008, when she led the company through its initial public offering and massive growth.During her last years at eBay, she is blamed for not being able to halt the sales slowdown and overpaying for the 2005 acquisition of Skype with 4.1 billion dollars. In 2009, Skype was sold by eBay at a valuation of 2.75 billion dollars.Whitman won the Republican nomination for governor of California in 2010. She lost the election to Gov. Jerry Brown after spending more than 140 million dollars of her own fortune on the campaign. EnditemHP said the appointments are effective immediately, following the decision that Apotheker stepped down as president and CEO and resigned as a director of the company.Multiple U.S. media reported on Wednesday that Apotheker was to be ousted, sending HP shares soaring on the market and in the after-hour trading.Apotheker, 58, was named HP CEO 11 months ago to replace Mark Hurd, who was ousted due to a scandal over a personal relationship with a company contractor and then became co-president of Oracle. Before HP, Apotheker had served as CEO of German software giant SAP for 10 months.On Aug. 18, Apotheker announced that HP will shut down its mobile business, spin off its core personal computer business and transfer into a cloud-based software and services provider for businesses including a 10.3 billion-dollar acquisition of British software company Autonomy.Shares of the company plunged 20 percent the following day, the worst one-day loss since Black Monday in 1987.On Sept. 30, 2010, the day before Apotheker's appointment as HP CEO, the tech giant's stock closed at 42.04 dollars. On Tuesday, the price closed at 22.47 dollars, a decrease of 46.6 percent in less than a year.On Monday, HP was reported to begin sending over 500 employees pink slips in the WebOS division, after announcing to stop making WebOS devices in August.
LOS ANGELES, July 18 (Xinhua) -- U.S. scientists have proven that oncogenes can change normal cells into stem-like cells, paving the way to a safer and more practical approach to treating diseases like multiple sclerosis and cancer with stem cell therapy.In a collaborative study, researchers from the Keck School of Medicine of the University of Southern California (USC), and the Children's Hospital of Orange County (CHOC) in California and Good Samaritan Hospital Medical Center in New York have successfully converted human skin cells into brain cells by suppressing the expression of p53, a protein encoded by a widely studied oncogene. This suggests that p53 mutation helps determine cell fate -- good or bad -- rather than only the outcome of cancer.Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells.Study findings were appearing Monday on the website of the American Association for the Advancement of Science (AAAS)."The reality may be more complicated than people think," said Jiang F. Zhong, Ph.D., assistant professor of pathology at the Keck School. "What is a stem cell gene? What is a cancer gene? It may be the same thing.""When you turn off p53, people think the cell becomes cancerous because we tend to focus on the bad thing," Zhong said. "Actually, the cell becomes more plastic and could do good things, too. Let's say the cell is like a person who loses his job (the restriction of p53). He could become a criminal or he could find another job and have a positive effect on society. What pushes him one way or the other, we don't know because the environment is very complicated."Stem cells can divide and differentiate into different types of cells in the body. In humans, embryonic stem cells differentiate into three families, or germ layers, of cells. The reasons why and how certain stem cells differentiate into particular layers are not clearly understood. However, from those layers, tissues and organs develop. The endoderm, for example, leads to formation of the stomach, colon and lungs, while the mesoderm forms blood, bone and heart tissue. In its study, Zhong's team examined human skin cells, which are related to brain and neural cells from the ectoderm.When p53 was suppressed, the skin cells developed into cells that looked exactly like human embryonic stem cells. But, unlike other man-made stem cells that are "pluripotent" and can become any other cells in the body, these cells differentiated only into cells from the same germ layer, ectoderm."IPSCs (induced pluripotent stem cells) can turn into anything, so they are hard to control," Zhong said. "Our cells are staying within the ectoderm lineage."Zhong said he expects that suppressing other oncogenes in other families of cells would have the same effect, which could have critical significance for stem cell therapy. Future research should focus on determining which genes to manipulate, Zhong said.The study is slated to appear in the Proceedings of the National Academy of Sciences later this month, according to AAAS.
CANBERRA, Sept. 6 (Xinhua) -- A rare virus that can be contracted by humans has killed a large number of Victorian pigeons after being detected in the Australian state for the first time, Agriculture Department confirmed on Tuesday.According to the Australian Chief Veterinary Officer, Dr Mark Schipp, the avian paramyxo virus has already started killing some hobby birds, and threatens to spread to Victoria's chicken population.He said the affected birds have died suddenly in large numbers and have sometimes appeared tired or have shown neurological signs such as circling or head flicking before death.He added that the bug can also cause conjunctivitis or influenza-like symptoms in humans."The virus causes only mild, short-term conjunctivitis or influenza-like symptoms (in humans)," Australia Associated Press quoted Schipp as reporting on Tuesday."Human infection with this virus is extremely rare and usually occurs only in people who have close direct contact with infected birds."At this stage, there are no reports of the virus causing disease in wild birds, but the Australian Wildlife Health Network has been asked to monitor the situation.
LOS ANGELES, July 3 (Xinhua) -- Warming of the ocean's subsurface layers will melt underwater portions of the Greenland and Antarctic ice sheets faster than previously thought, increasing the sea level more than already projected, a new study suggests.The subsurface ocean layers surrounding the polar ice sheets will warm substantially as global warming progresses, according to the study led by researchers from the University of Arizona (UA).In addition to being exposed to warming air, underwater portions of the polar ice sheets and glaciers will be bathed in warming seawater, said the study appearing on the website of the American Association for the Advancement of Science (AAAS) on Sunday.The research, based on 19 state-of-the-art climate models, proposes a new mechanism by which global warming will accelerate the melting of the great ice sheets during this century and the next."To my knowledge, this study is the first to quantify and compare future ocean warming around the Greenland and the Antarctic ice sheets using an ensemble of models," said lead author Jianjun Yin, a UA assistant professor of geosciences.According to the study, the subsurface ocean along the Greenland coast could increase as much as 3.6 F (2 C) by 2100.Most previous research has focused on how increases in atmospheric temperatures would affect the ice sheets, he said."Ocean warming is very important compared to atmospheric warming because water has a much larger heat capacity than air," Yin said. "If you put an ice cube in a warm room, it will melt in several hours. But if you put an ice cube in a cup of warm water, it will disappear in just minutes."Given a mid-level increase in greenhouse gases, the researchers found the ocean layer about 650 to 1,650 feet (200 to 500 meters) below the surface would warm, on average, about 1.8 F (1 C) by 2100. Along the Greenland coast, that layer would warm twice as much, but along Antarctica would warm less, only 0.9 F (0.5 C)."No one has noticed this discrepancy before -- that the subsurface oceans surrounding Greenland and Antarctica warm very differently," Yin said.Part of the warming in the North comes from the Gulf Stream carrying warm subtropical waters north. By contrast, the Antarctic Circumpolar Current blocks some of the subtropical warmth from entering the Antarctic's coastal waters.Even so, the Antarctic ice sheet will be bathed in warming waters, according to the study.This paper adds to the evidence that sea level would rise by the end of this century by around one meter and a good deal more in succeeding centuries, the study noted.The study, "Different Magnitudes of Projected Subsurface Ocean Warming Around Greenland and Antarctica," is scheduled for the upcoming edition of Nature Geoscience later this month.