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Holidays will look different this year for many Americans, with dinners outside, social distancing, or passing on family gatherings altogether. But several companies developing rapid at-home COVID-19 tests are hopeful that won't be the case next year. The goal is to make inexpensive, easy-to-use COVID tests that can deliver results in minutes, just like a pregnancy test. "For people to feel comfortable to associate with friends or family, there needs to be a testing methodology ideally that can be performed at home," said Tony Lemmo, CEO of the manufacturing company BioDot.The company's technology is being used by over 70 manufacturers worldwide making COVID-19 antigen, antibody, and PCR tests. Their automated platforms dispense nanoliter/picoliter amounts of reagent onto the tests accurately and fast.Lemmo says just one of their systems can support the production of roughly 100 million COVID-19 tests per year, helping to make high-volume production possible.“We knew we were going to be called on by customers to manufacture more equipment to provide them the ability to manufacture more tests," said Lemmo. To meet customer demand, BioDot increased staffing and built a new facility, compressing production time from months to weeks. The FDA recently authorized the first rapid at-home test that can deliver results in 30 minutes, eliminating the need for a lab to test the sample. But the molecular single-use test will only be available to patients with a doctor's prescription who are suspected of being infected with COVID-19.Companies developing tests hope the FDA will soon authorize another at-home testing tool: the rapid antigen test.These inexpensive tests provide results within minutes, and companies developing them say millions could be sold without a doctor's referral.“From what we’re hearing, it’s really just a matter of possibly months before there’s at least sufficient data to be able to support an at-home use of a test like an antigen test," said Lemmo.Lemmo says if authorized by the FDA, manufacturers could make millions of these tests in a matter of months. But antigen tests are less accurate, and the FDA wants to ensure they'll be simple enough for people to use at home. There are also concerns over how the data will be reported to health authorities. “I think any at-home testing or massive rollout of a test into the communities needs to be done very carefully and with a lot of education around it," said Clinical Lab Director Melissa Miller. Dr. Miller is a professor of pathology and laboratory medicine at the University of North Carolina Chapel Hill and Medical Director for the Clinical Microbiology Lab for the Medical Center.She worries the inaccuracies of these tests could eventually lead the public to lose trust in all testing. “Even at 98 percent specificity, which is very, very high. That means you’re going to have a false positive two out of every 100. If you started testing a hundred million people, this is millions of people who have a false-positive test," said Dr. Miller. She says this could lead to healthy people isolating and missing work or school unnecessarily, and false-negative results could give people a false sense of security. “These rapid antigen tests were pushed out to skilled nursing facilities; this is a very high-risk patient population. This is actually where you want a very accurate test," said Dr. Miller. She says it’s unclear how well antigen tests detect the virus in asymptomatic patients but agrees more data is needed to figure that out.“It might make more sense for K-12 schools, or even college settings, where there’s less risk for a poor outcome if you have a false positive or a false negative," said Dr. Miller. But with a growing demand for convenient at-home testing, manufacturers are hopeful that in the months ahead, the FDA will soon open the door to new solutions. 3889

Google has marked Mexico's Day of the Dead, an ancient festival celebrating and honoring departed loved ones, with a doodle featuring brightly painted model skulls.The skulls, hand-made from clay, appear between animated flickering candles with orange marigold petals scattered around them. The doodle represents the ofrendas, or altars, set up by families for the carnival.The shrines typically feature photographs and treasured mementos of late relatives and friends, plus their favorite foods and drinks.A type of sweet roll known as dead bread and sugar skulls are also often included, along with orange candles and incense. Homes are decorated with sprays of marigolds as part of the tradition.Revelers in colorful costumes with skulls painted on their faces parade through the centers of towns, and a host of celebrations and parties take place. Offerings are placed in graveyards and at the sides of roads. 921

George Clooney wrote an open letter to the survivors of the Parkland school shooting, praising them for making him "proud of his country again."The letter was published on Friday in The Guardian's website, where student journalists from Marjory Stoneman Douglas High School are guest editing the newspaper's online coverage of the March for Our Lives event on Saturday.In an editor's note published with the letter, Emma Dowd, Lauren Newman and Rebecca Schneid, co-editors-in-chief of the school paper Eagle Eye, said they reached out to a number of politicians and celebrities for interviews, including George Clooney and his wife Amal, who donated 0,000 to support the march."They turned us down on the interview, but we loved the letter George sent us back," the three students wrote.In the letter, Clooney thanked them for what they are doing to promote safer gun laws, saying, "Amal and I stand behind you, in support of you, in gratitude to you.""Amal and I are 100% behind you and will be marching in DC on the 24th, but we both feel very strongly that this is your march. Your moment," Clooney wrote. "Young people are taking it to the adults and that has been your most effective tool. The fact that no adults will speak on the stage in DC is a powerful message to the world that if we can't do something about gun violence then you will. The issue is going to be this, anyone you ask would feel proud to be interviewed by you but it's so much more effective if it's young people."Related: What you should know about the March for Our LivesThe Guardian on Friday said they invited the students to serve as guest editors for the next 48 hours and the students appear to be taking full advantage of the opportunity to make themselves heard on gun control issues."We hope to use the Guardian's platform to heighten awareness of the issue of gun control and school safety to such an extent that the federal government can no longer ignore us," they said in their editor's note.March for Our Lives is an event created and organized by #NeverAgain, a group of students who survived the February 14 shooting that claimed 17 lives at Marjory Stoneman Douglas High School in Parkland, Florida. Everytown for Gun Safety, a gun control advocacy group, is helping the students plan and coordinate the event.The main march will be held in Washington, D.C., with more than 800 related events taking place around the world.Oprah Winfrey and Steven Spielberg are among the other celebrities who have donated 0,000 each in support of the march.Event organizers have also raised more than million through a GoFundMe campaign that was launched a few days after the shooting.  2687

Here is when the driver first pulled up to the protesters tonight in Denver, you can hear people urging him to turn around. During the next few minutes, I saw the driver shaking his head in apparent disbelief and using his cell phone, perhaps to take pictures. pic.twitter.com/TSAzfipida— Shelly Bradbury (@ShellyBradbury) September 24, 2020 349

Hillary Clinton on Thursday slammed Republican Gov. Paul LePage's recent announcement that he won't expand Medicaid in Maine until the state finds a way to pay for it even though voters approved a ballot measure supporting the program's expansion."Who appointed these people king?" Clinton asked.Speaking at a health care symposium at Geisinger Medical Center near Danville, Pennsylvania, Clinton said compromise should be a key tenet for improving health care in the United States. 490

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