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The first large head-to-head comparison of two opioid addiction medications found that, although they were equally effective in getting people off of high levels of opioids, users had a significantly more difficult time starting a regimen of naltrexone, compared with buprenorphine.Buprenorphine is commonly known by the the brand name Suboxone, and naltrexone is sold under the brand name Vivitrol.The study, published Tuesday in the Lancet, looked at 570 patients with opioid addiction at eight inpatient treatment centers across the country for 24 weeks. Half of the group was assigned to naltrexone and the other half to bupenorphine.Six percent of those enlisted to use buprenorphine were unable to start their treatment, whereas 28% of those assigned to naltrexone dropped out before starting the therapy. 824

The Federal Reserve is warning that an escalating trade war would pose a big threat to the economy.But for now, it's sticking with its plan to raise interest rates — whether President Donald Trump likes it or not.In minutes of its most recent meeting, released Wednesday, central bankers warned that a "major escalation" of trade disputes could speed inflation and cause businesses to pull back on investment.Such an escalation could also reduce household spending and disrupt companies' supply chains, participants noted.Some business leaders reported that recent tariff increases have already begun to cause higher prices. Others have reduced or delay investment spending because of uncertainty about future trade policy.Still, some Federal Open Market Committee members noted that most businesses concerned about trade disputes hadn't cut back their spending or hiring, but "might do so if trade tensions were not resolved soon."In the meantime, the central bank is standing by its plan for higher rates as the economy strengthens, according to the minutes.The Fed is expected to raise rates twice more this year, starting in September.The Fed meeting, held July 31 and August 1, was the first after Trump began lashing out at Fed Chairman Jerome Powell for hiking rates. The president told CNBC in July that was "not thrilled" with the Fed's actions.He used similar language on Monday in an interview with Reuters, arguing the central bank should be doing more to help the economy."I should be given some help by the Fed," said the president, who himself appointed Powell to lead the central bank.Presidents have historically avoided commenting on Fed policies. The central bank is designed to be independent from political interference.The Fed's minutes made no mention of Trump's criticism as a factor in its decision-making.Since Trump took office, the Fed has raised rates five times, including twice this year under Powell. The Fed has been carefully and gradually raising rates over the past several years to keep inflation in check and prevent the economy from overheating.After two further rate hikes in 2018, it has penciled in three more rate hikes in 2019.Fed Chairman Jerome Powell told the "Marketplace" radio show in July that he was "deeply committed" to maintaining Fed independence."We do our work in a strictly nonpolitical way, based on detailed analysis, which we put on the record transparently, and we don't take political considerations into account," Powell said in the interview.Powell is expected to speak on Friday at an annual economic symposium in Jackson Hole, Wyoming. 2611

The excitement of two COVID-19 vaccines with more than 90 percent efficacy is undeniable.In November, both Pfizer and Moderna announced its scientists had developed vaccines with efficacy at or near 95 percent, but scientists are warning these vaccines are not the "silver bullet" to ending the pandemic.“We don’t want to give the public the impression that there’s an emergency use authorization and these vaccines become available in a small amount in December and we can go back to our pre-pandemic behavior,” said William Moss, executive director of the International Vaccine Access Center at Johns Hopkins.In June, the FDA released its vaccine guidelines, saying it would consider emergency use authorization for any vaccine testing with at least 50 percent effectiveness, so there is a reason for celebration, according to Moss, but only after certain questions about the vaccine are answered.Dr. Anthony Fauci has said the initial vaccines will prevent symptoms in those who become infected, rather than kill the virus itself. Moss says that means immunized people might be able to spread COVID-19 to others.He also wonders how long immunization will last. One year? Three years? Will booster doses be needed? They're all careful considerations that will only emerge once one is put into play, according to Moss.“It’s obviously tragic that the [COVID] cases are occurring that quickly, but it does help a vaccine trial because otherwise you just have to wait that much longer for samples to come in,” said Moss.The vaccine process has innovated how scientists and researchers approach these types of situations, however, according to Moss.In traditional vaccines, a small dose of the virus is injected into the body so the immune system can create antibodies. In the COVID-19 vaccine, though, both Moderna and Pfizer have used what is called messenger RNA (mRNA) where the virus’ genetic code is injected into the body so it can instruct cells on what antibodies to produce. Scientists say this way is faster, safer, and can create a stronger immune response as people are not exposed to the virus.“I suspect that if this all goes well and these vaccines are safe and continue to demonstrate 90 to 95 percent efficacy, we’re going to see other vaccines of a similar type,” said Moss. 2298

The Chico Mall has everything you'd expect to find there during the holiday season -- non-stop Christmas music, trees and oversized ornaments, along with signs advertising great deals for increasingly frenzied shoppers.It also has a temporary classroom space and a FEMA Disaster Recovery Center to help people who lost their homes in the Camp Fire, which devastated nearby Paradise, California, and the surrounding area.While they're at the mall to sign up for benefits or take care of other business, a lot of parents are bringing their kids to meet Santa Claus, said Jim Hoskins, the Chico Mall Santa.The Kentucky native, who said he'd prefer you call him Santa, has a gentle voice and a kind smile. He ended his interview with a quick "Ho, ho, ho" as he hung up the phone.He said you'd never know that many of the children he's met had lost their homes."Most of them are smiling," he said, though he does have to win over the occasional crier. "They are astounding."The kids' basic needs have been taken care off, thanks to FEMA and the generosity of the community, Hoskins said, so they're asking Santa for dirt bikes, iPhones, Paw Patrol toys and something called L.O.L Surprise dolls.But many of them do ask for something that Santa can't give -- a home."I usually say 'I can't do this in a year. I don't have the magic to do it right now, but we will get you one,'" he said. "I can't give them instant gratification on that, but I can give them some satisfaction that it will be done."He said some children have been concerned that Santa wouldn't be able to find them since their homes have burned down. He says they don't need to worry about that."I say 'I know your relatives and I've got GPS to track you with,'" he said. "It makes them feel better once their parents confirm it."Kylie Wrobel took her 7-year-old daughter, Ellie, to see Santa on Saturday.The first thing she asked for was toys for her dog, Daisy."She has the biggest heart," Wrobel said. "She was worried about our dog before herself, and then she asked for a Barbie mansion."Wrobel said she only grabbed her cell phone charger before leaving her Paradise rental house. She didn't have rental insurance, so they lost everything.Wrobel usually takes a picture of her daughter and Santa on her phone instead of buying one from the mall, she said, but this year's photo was really cute -- and it's the only hard copy photo they have now.They picked out a frame and put it out in the trailer where they're living, she said, along with their "Elf on a Shelf."Kathleen Mahnke said that Santa waved at her twin boys, who are about to turn two, as they they were walking through the mall to the FEMA center."As a mom, I can tell who is a kid lover," she said. "He was kind and fun, and patient with understanding that young kids take a while to warm up to strangers."She said she also appreciated the mall offering half off the photo packages for people who went through the fire.Hoskins says he's amazed by how resilient the children and their parents are when he meets them."I see more positive outlooks and attitudes than I do negative," he said. 3141

The FBI continues to investgate reports of a #jetpack near #LAX on 8/30. Anyone with info about activity on or above the ground at the location depicted here should call the FBI. The FBI takes seriously events that threaten US airspace & investigates alleged violations #SafeSkies pic.twitter.com/dLZcZeRDuc— FBI Los Angeles (@FBILosAngeles) September 4, 2020 377

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