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SAN DIEGO (KGTV) — The National Institutes of Health highlighted research Tuesday out of UC San Diego that could unlock a new way to treat COVID-19.The research reveals new insight into how the coronavirus hijacks cells, and how doctors might be able to set traps or decoys to combat the virus. The findings were published in the journal Cell last month.“It does open up another avenue for a potential treatment,” said UC San Diego distinguished professor Dr. Jeffrey Esko. “It’s not a cure. It would be something that would tamp down infection potentially.”Since January, scientists around the world have understood that SARS-Co-V2, the official name of the new coronavirus, enters cells by latching onto a specific receptor on the cell’s surface, called ACE2.The UCSD team, led by Dr. Esko and visiting scholar Dr. Thomas Clausen, discovered that this entry mechanism is actually a two-step process, and the virus must also attach to a long chain of sugars called heparan sulfate.“We’ve shown this is fundamental to the infectious mechanism, so it needs to be part of every study from now on,” said Clausen.All cells are coated with a complex layer of sugars, or carbohydrates, called glycans. Heparan sulfate is one type of glycan that is known to play a key role in the infection process in several viruses, including herpes and other coronaviruses.It’s a complicated process to picture so the researchers offer an analogy: imagine a bird, soaring over trees, hunting a worm on the forest floor. The bird is the coronavirus and the trees are the thick layer of glycans that coat the surface of the cell.To reach the worm, which in this case is the receptor ACE2, the bird must navigate its way through the trees, specifically through heparan sulfate.The UCSD found that by removing the heparan sulfate trees with an enzyme, they were able to prevent the virus from infecting cells. In laboratory testing, they also found a second technique worked to foil the virus: introducing more trees as bait.The team found that heparin, an FDA-approved drug that is similar in structure to heparan sulfate, successfully acted as decoy. Heparin is a widely used drug designed to treat blood clots. Since blood clots and strokes are common complications with COVID-19, many doctors already administer heparin to patients.The UCSD team demonstrated that the two approaches can block infection in lab-grown cells about 80 to 90 percent of the time.“Certainly in the laboratory you can demonstrate that it works, but to deploy it and use it as a therapeutic has not been demonstrated,” Esko said.The NIH noted that more studies are planned to explore whether heparin, heparan sulfate, or drugs that target heparan sulfate might yield a viable COVID-19 treatment.Dr. Esko said he’s already been in talks with companies that plan to use their study as a rationale for a clinical trial.“It is very humbling when you realize we’re working on a pandemic right now, and maybe what we’ve done can contribute to a treatment for the disease,” he said. 3038

SAN DIEGO (KGTV) -- The journey has come to an end for hundreds of migrants seeking asylum in the U.S.A large caravan arrived in Tijuana within the last week and have waited until Sunday to cross the border into San Diego.Late Sunday afternoon, members of the caravan plan to turn themselves in to customs agents seeking asylum.Most of the roughly 400 migrants in the caravan are women and children who have been staying in shelters, seeking legal counsel before trying to cross the border.RELATED: Migrant caravan warned asylum may lead to separation from childrenBorder patrol agents released a statement Saturday saying several groups associated with the caravan have been illegally climbing a scrap metal border fence.The statement warned anyone with the caravan to “think before you act.” The Secretary of Homeland Security also said in a statement earlier this week that anyone seeking asylum “may be detained while their claims are adjudicated.”Protesters say the group is taking advantage of U.S. immigration laws. A group called San Diegans for Secure Borders plans to protest at Friendship Park.They say the migrants are unwelcome and that their claims for asylum are false. A protest was held on both sides of the border Sunday morning. Watch video from the protest in the player below:  1321

SAN DIEGO (KGTV) -- Surveillance video captured the moment after a thief stole a woman's wallet inside a Midway District grocery store.According to San Diego Crime Stoppers, the theft happened on Sept. 23 inside the Ralph’s grocery store located at 3345 Sports Arena Blvd.While the 73-year-old female victim was in the freezer section, the man waited for the victim to open a freezer door and then approached her shopping cart. The suspect quickly removed the victim's wallet from her purse, which was placed at the top of the shopping cart.The victim was right next to the cart but was looking inside a freezer when the theft occurred.The suspected thief walked away without the victim realizing what had happened. The total loss of the wallet and cash inside it is over ,500.Investigators reviewed store surveillance footage, which showed the man following the victim throughout the store and appearing to target her.The suspected thief is described as a white male, approximately 5’10“ tall, 175 lbs., with tanned skin. He was wearing a light-colored baseball cap with black sunglasses on the front of the cap, a light green short-sleeve button-up shirt, gray shorts, and black sandals.Anyone with information should call the San Diego Police Department's Western Division at (619) 692-4800 or the Crime Stoppers anonymous tip line at (888) 580-8477.Crime Stoppers is offering up to a ,000 reward to anyone with information that leads to an arrest. 1463

SAN DIEGO (KGTV) — Target cash registers suffered a nationwide outage Saturday, leaving some customers around the country sitting in line for hours.The company's corporate office said an "internal technology issue" shut down registers for about two hours Saturday, preventing customers from making purchases in store.Target added that the technology issue was not a data breach or security-related issue and that customer data was no compromised. By 2:30 p.m., Target said their systems were back online:"Target’s registers are fully back online and guests are able to purchase their merchandise again in all stores. The temporary outage earlier today was the result of an internal technology issue that lasted for approximately two hours. Our technology team worked quickly to identify and fix the issue, and we apologize for the inconvenience and frustration this caused for our guests. After an initial but thorough review, we can confirm that this was not a data breach or security-related issue, and no guest information was compromised at any time. We appreciate all of our store team members who worked quickly to assist guests and thank everyone involved for their patience."10News has reached out to Target to see how many stores in San Diego were affected by the outage, but have not heard back.Twitter users across the country took to chronicle their "#TargetDown" experience online, ranging from long wait times, abandoning carts full of groceries, and some checking in — and out — of work at a location as the outage continued.#targetdown I was able to get out in a little over an hour because my cashier would not give up. He had to scan every single item at least 10 times but it worked. They are still turning away people at the door. pic.twitter.com/jbEzBcIjmj— Naomi Thompson ?? (@NaominotNyomi) June 15, 2019I moved from Manhattan to Brooklyn this morning faster than I can check out at @Target. #TargetDown pic.twitter.com/Eko97zgXBS— tanya (@thetiebandit) June 15, 2019I was at Target. Seems to be no end in site for the register outage or the forming lines. I abandoned cart and left... can't waste my whole day there. #targetdown #targetoutage pic.twitter.com/IolXjTIjOz— Jeff of The Game Capital & The Poke Capital (@ThePokeCapital) June 15, 2019Every Target register in the country is down! This is crazy. Been on line for 30 minutes!!#targetdown pic.twitter.com/MLPcP6QEng— IceburG?? (@So_Ice_Cold) June 15, 2019Just left target after patiently waiting for an hour or so. Every single person working there is amazing & I honestly feel for them. I just had to take the L. If you’re still there, please be patient with these guys. They are doing their best! #targetdown pic.twitter.com/yBcEYL4Jsx— Elizabeth Matthews (@momof2boys79) June 15, 2019A similar issue hit Target stores in 2014. That outage appeared to be a "glitch" causing delays at checkouts, "but is not in any way related to a security issue." 2951

SAN DIEGO (KGTV) — The alarm blares in your ears, as your eye lids slowly peak open and usher in a flood of sunlight. You drag your feet along the floor to the kitchen, where a device that has saved mornings for so many awaits you.Coffee is often regarded as a necessity to begin the day, but sometimes it's just what the doctor ordered for a relaxing day. In San Diego, several local coffee roasters and houses blend together their unique coffee recipes that can both kickstart your day or provide a warm moment of solace.And as National Coffee Day comes on Sept. 29 this year — a Sunday — there's no better time to wake and relax at a coffee house before the work week kicks into gear. While you're out and about, be sure to duck into one of San Diego's many coffee houses to sample their invigorating drinks:Bird Rock Coffee Roasters (Locations in La Jolla, Bressi Ranch, Little Italy, Torrey Pines, Morena, Pacific Beach): Bird Rock boasts high-quality coffee, their own signature mixes, and seasonal blends of delicious coffees at their locations around town.Better Buzz (Locations in La Jolla, Pacific Beach, Hillcrest, Encinitas, Fashion Valley, Point Loma, Mission Beach, San Marcos): In addition to their signature drinks like "Best Drink Ever" and "Hazelnut Divinity," Better Buzz offers delicious cold brews, mochas and lattes, and eats to match.Dark Horse Coffee Roasters (Locations in Normal Heights, North Park, Golden Hill, La Mesa): Head over to Dark Horse Coffee Roasters for their signature Espresso drinks, like “The Champ” or cold brew on nitro with a splash of vanilla bean syrup.Lofty Coffee & Bakery (Locations in Solana Beach, Encinitas, Little Italy): Lofty Coffee roasts its own beans and crafts pastries from scratch at hubs along San Diego's coastal communities.Jennings House Cafe: One of San Diego's oldest coffee brands, Jennings House Cafe serves up Cura Coffee and delicious breakfast dishes in a historic landmark home dating back to 1886.The WestBean Coffee Roasters (Locations in downtown, Liberty Station, Bankers Hill): WestBean sources its own beans, churning out some delicious espressos and refreshing cold brews.James Coffee Co. (Locations in Little Italy, Bankers Hill, downtown, Columbia): James Coffee Co. puts together your traditional brews plus some delicious specialty drinks with honey cinnamon, Mexican mocha, or coffee soda.Philz Coffee (Locations in La Jolla, Del Mar, Encinitas): The Bay Area brings specialty beans — 28 types of beans, in fact — involving a variety of flavors like grapefruit, Cherry, maple, and others.Refill: Refill packs its java house with all the needed brews: Mochas, lattes, cappuccinos, and some delicious cold brew concoctions and crepes.Modern Times: In Modern Times' Lomaland Fermentorium, the brewery roasts its own beans in a modest roaster beside taps of its brews. And of course, so of those beans have crossed over to combine barrel-aged beans.Heartwork: San Diegans have long been fans of Heartwork's brews using James Coffee Co. and Dark Horse roasted beans.Moniker Coffee Co.: A variety of small-batch coffee from local producers and some out-of-town roasters can be found at Moniker's Liberty Station stop.Communal Coffee (Locations in South Park, North Park): Grab a cup of coffee and flowers on the side! Communal Coffee, which serves Sightglass Coffee from San Francisco. Expect some creative drinks like rose vanilla, taro, and sea salt and caramel coffees.Revolution Roasters (Location in Oceanside): Fresh-baked pasteries, breakfast dishes, and of course, an awakening variety of coffees awaits at Revolution Roasters, including their signature Lavender Honey and Butterscotch lattes.SkyBound Coffee + Dessert Lounge (Locations in Vista, Downtown San Diego): Whether you want your coffee hot or cold, SkyBound has what you need with their Skybound Dark Chocolate Mocha, iced lavender vanilla, sea salt, or VanillaCali coffees.Perks Coffee House (Location in San Marcos): Delicious cold brew on tap, freshly roasted beans, and a variety of Espresso drinks will surely perk your senses at Perks Coffee House. Keep an eye on their seasonal Cafe Viennese, Dirty Chai latte or go for something a little harder like Irish Coffee. 4234