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WASHINGTON, May 11 (Xinhua) -- Johns Hopkins University researchers have demonstrated that human liver cells derived from adult cells coaxed into an embryonic state can engraft and begin regenerating liver tissue in mice with chronic liver damage.The work, published Wednesday in the journal Science Translational Medicine, suggests that liver cells derived from so- called "induced-pluripotent stem cells (iPSCs)" could one day be used as an alternative to liver transplant in patients with serious liver diseases, bypassing long waiting lists for organs and concerns about immune system rejection of donated tissue."Our findings provide a foundation for producing functional liver cells for patients who suffer liver diseases and are in need of transplantation," says Yoon-Young Jang, assistant professor of oncology at the Johns Hopkins Kimmel Cancer Center. "iPSC-derived liver cells not only can be generated in large amounts, but also can be tailored to each patient, preventing immune-rejection problems associated with liver transplants from unmatched donors or embryonic stem cells." A microsopic view shows human embryonic stem cells in various stages of differentiation into liver cells in this photo taken at Stanford University and released by the California Institute for Regenerative Medicine, March 9, 2009iPSCs are made from adult cells that have been genetically reprogrammed to revert to an embryonic stem cell-like state, with the ability to transform into different cell types. Human iPSCs can be generated from various tissues, including skin, blood and liver cells.Although the liver can regenerate in the body, end-stage liver failure caused by diseases like cirrhosis and cancers eventually destroy the liver's regenerative ability, Jang says. Currently, the only option for those patients is to receive a liver organ or liver cell transplant, a supply problem given the severe shortage of donor liver tissue for transplantation. In addition, mature liver cells and adult liver stem cells are difficult to isolate or grow in the laboratory, she says. By contrast, iPSCs can be made from a tiny amount of many kinds of tissue; and the embryonic stem- like iPSCs can grow in laboratory cultures indefinitely.For the study, Jang and colleagues generated human iPSCs from a variety of adult human cells, including liver cells, fibroblasts ( connective tissue cells), bone marrow stem cells and skin cells. They found that though the iPSCs overall were molecularly similar to each other and to embryonic stem cells, they retained a distinct molecular "signature" inherited from the cell of origin.
SHANGHAI, Feb. 8 (Xinhua) - Shanghai World Expo authorities said that about 300,000 tourists have visited the China Pavilion of the expo during the seven-day Spring Festival holiday, as of Tuesday evening.Daily peak was recorded at 48,000 visitors, authorities said late Tuesday.The China Pavilion had been adorned with a new logo of a rabbit and two carrots to mark the country's Lunar New Year celebrationsMore than 1,500 staff, police and volunteers were assigned to the China Pavilion to ensure public safety during the holiday.The organizers also sold tickets in advance and extended opening hours to accommodate the large number of visitors.Overseas and domestic tourists from outside Shanghai comprised 70 percent of the total visitors during the holiday, according to a survey by the organizer.The China Pavilion of the Shanghai World Expo had reopened on December 1, 2010 and will remain open to the public until the end of May this year.

SAN FRANCISCO, March 22 (Xinhua) -- Apple Inc. on Tuesday announced that iPad 2, the second-generation of its popular tablet computer, will be available in China's Hong Kong, Korea, Singapore and additional countries and regions in April.The company also confirmed that iPad 2 will go on sale in 25 countries on March 25 in addition to the United States, where the device first hit market on March 11 and has seen strong demand."While competitors are still struggling to catch up with our first iPad, we've changed the game again with iPad 2," Steve Jobs, Apple's chief executive officer, said in a statement."We're experiencing amazing demand for iPad 2 in the U.S., and customers around the world have told us they can't wait to get their hands on it. We appreciate everyone's patience and we are working hard to build enough iPads for everyone," he noted.Apple had planned to released iPad 2 in Japan on March 25, but delayed the launch in the aftermath of the catastrophic March 11 earthquake and ensuing tsunami in the country.The 25 countries where iPad 2 will go on sale on March 25 include Australia, Austria, Belgium, Canada, the Czech Republic, Denmark, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Luxembourg, Mexico, the Netherlands, New Zealand, Norway, Poland, Portugal, Spain, Sweden, Switzerland and Britain.
LOS ANGELES, May 15 (Xinhua) -- Using a simple, minimally- invasive technique to analyze cells from the interior of the nose, U.S. researchers have detected lung cancer in its earliest stage.For the study, the researchers at the Boston University Medical Center collected nasal epithelial cells from thirty three smokers who were undergoing medically-indicated bronchoscopies for suspicion of lung cancer, according to the American Association for the Advancement of Science (AAAS) on Sunday.Of these patients, 11 were found to have benign disease and 22 had lung cancer. Brushings were taken from the right or left nostril and profiled on microarrays, a process that allows researchers to study gene expression changes.The researchers identified 170 genes that were differentially expressed between patients with and without lung cancer. They also found that genes linked to colon cancer and adenocarcinoma, as well as genes that trigger cell division and blood vessel growth, were expressed more heavily in patients with cancer. Genes involved in tumor suppression were also expressed at lower levels in these patients.Earlier studies have used gene expression differences in the bronchial airways to identify lung cancer in its early stages. The researchers relied on those results to design the current study."In this study we used the same principle as we used in our earlier studies of bronchial tissue, only this time, those methods were used to study nasal cells," said study author Christina Anderlind, MD, Instructor of Medicine. "Our hypothesis was that the upper airway epithelium of smokers with lung cancer displays a cancer-specific gene expression pattern, and that this airway nasal gene expression signature reflects the changes that occur in lung tissue."
ACCRA, Feb. 12 (Xinhua) -- China would in the coming years inject more capital to support the infrastructure needs of Ghana, Chinese Ambassador to Ghana Gong Jianzhong has said.Briefing the media here on Friday night to announce the visit to Ghana by Chen Deming, the Chinese Minister of Commerce, Ambassador Gong said that China is willing to join in the infrastructure development of Ghana."We are willing to join Ghana in improving its infrastructure base. We will be happy to give our contribution towards the infrastructure development of Ghana," he said.The forthcoming two-day visit by the Chinese minister would afford the two countries to further cement, promote and syncretize the bilateral trade and economic corporation existing between them for more than five decades.The ambassador said the Chinese Embassy in Ghana is committed to offering quality service to Ghanaians engaging in bilateral exchanges and cooperation in different fields.Currently, China has supported the West African country in the construction of various roads, rails, school blocks, hospitals, among others.He called on the Chinese firms in Ghana to raise investments and take corporate social responsibilities in local communities where they are operating.
来源:资阳报