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WASHINGTON, Sept. 14 (Xinhua) -- Controlling diabetes may someday involve mining stem cells from the lining of the uterus, Yale School of Medicine researchers report in a new study published Wednesday in the journal Molecular Therapy. The team treated diabetes in mice by converting cells from the uterine lining into insulin-producing cells.The endometrium or uterine lining, is a source of adult stem cells. These cells generate uterine tissue each month as part of the menstrual cycle. Like other stem cells, however, they can divide to form other kinds of cells.Led by Yale Professor Hugh Taylor, the researchers bathed endometrial stem cells in cultures containing special nutrients and growth factors. Responding to these substances, the endometrial stem cells adopted the characteristics of beta cells in the pancreas that produce insulin. Over the course of a three- week incubation process, the endometrial stem cells took on the shape of beta cells and began to make proteins typically made by beta cells. Some of these cells also produced insulin.After a meal, the body breaks food down into components like the sugar glucose, which then circulates in the blood. In response, beta cells release insulin, which allows the body's cells to take in the circulating glucose. In this study, Taylor and his team exposed the mature stem cells to glucose and found that, like typical beta cells, the cultured cells responded by producing insulin. The team then injected diabetic mice with the mature, insulin-making stem cells. The mice had few working beta cells and very high levels of blood glucose.Mice that did not receive the stem cell therapy continued having high blood sugar levels, developed cataracts and were lethargic. In contrast, mice that received the cell therapy were active and did not develop cataracts, but the animals' blood sugar levels remained higher than normal.The Yale team's findings suggest that endometrial stem cells could be used to develop insulin-producing islet cells, which are found in the pancreas. These islet cells could then be used to advance the study of islet cell transplantation to treat people with diabetes.Taylor said in a statement that the next step in the research will be to verify how long this treatment remains effective.
Beijing, Sept. 6 (Xinhua) -- A sperm donation scandal disclosed recently has aroused growing concern in the United States.According to the New York Times' report, Ryan Kramer, the son of a donor, found that he has more than 150 half-siblings - they are all the children of the same donor."It's wild when we see them all together - they all look alike," said Cynthia Daily, mother of Kramer.As more women choose to have children on their own, the demand for sperm donors has surged.Some sperm banks are earning huge profits by allowing too many mothers to receive sperms from the same popular donors, according to the report.And this trend will lead to risks: rare genetic diseases could be spread more widely, and the children of the same donor could meet and, unbeknownst to them, commit incest, medical experts warned.Parents and donors are calling for a tighter regulation so that donor children can know more about their donors, and the number of kids from each donor can be limited.
BEIJING, Aug. 23 (Xinhuanet) -- More than 90 percent of U.S. heart attack patients who need the lifesaving procedure receive it within just 90 minutes of being admitted to the hospital, according to a study released Monday in the journal Circulation.The study on the American Heart Association's journal shows that in 2010, 91 percent of heart attack patients who needed angioplasty were treated within the 90-minute window. While in 2005, 44% were.Researchers analyzed data on more than 300,000 such patients who underwent emergency angioplasty between January of 2005 and October of 2010.The improvement is the result of a nationwide effort between federal agencies, health care organizations and health care providers to improve heart attack care and outcome, said study author Dr. Harlan M. Krumholz, a professor of medicine and epidemiology and public health at Yale University School of Medicine, according to U.S. News reports.
WASHINGTON, Aug. 2 (Xinhua) -- A new study has identified the recent emergence of a multidrug-resistant strain of Salmonella that has a high level resistance to ciprofloxacin, a common treatment for severe Salmonella infections. The study was published on-line Tuesday in The Journal of Infectious Diseases.Francois-Xavier Weill at the Pasteur Institute in France and colleagues studied information from national surveillance systems in France, England and Wales, Denmark, and the United States. The data showed that a multidrug-resistant strain of Salmonella, known as S. Kentucky, infected 489 patients in France, England and Wales, and Denmark between 2000 and 2008. In addition, researchers reported that the first infections were acquired mainly in Egypt between 2002 and 2005, while since 2006 the infections have also been acquired in various parts of Africa and the Middle East. The absence of reported international travel in approximately 10 percent of the patients suggests that infections may have also occurred in Europe through consumption of contaminated imported foods or through secondary contaminations.In this study, multidrug-resistant S. Kentucky was isolated from chickens and turkeys from Ethiopia, Morocco, and Nigeria, suggesting that poultry is an important agent for infection. The common use of fluoroquinolones in chicken and turkey production in Nigeria and Morocco may have contributed to this rapid spread, according to the researchers.This study highlights the importance of public health surveillance in a global food system. The investigators reported that they will continue to monitor this multidrug-resistant strain as well as help strengthen the capacities of national and regional laboratories in the surveillance of Salmonella and other major foodborne pathogens through the World Health Organization Global Foodborne Infections Network.Salmonella infection represents a major public health problem worldwide. An estimated 1.7 million such infections occur in North America each year. More than 1.6 million cases were reported between 1999 and 2008 in 27 European countries. Although most Salmonella infections produce only mild gastroenteritis, elderly and immunocompromised patients are especially at risk for life- threatening infections. These cases are typically treated with antimicrobials called fluoroquinolones, such as ciprofloxacin.
SAN FRANCISCO, Aug. 10 (Xinhua) -- Amazon on Wednesday launched Kindle Cloud Reader, a web-based app that may help the on-line retailer to sidestep Apple's App Store restrictions.In its announcement, Amazon said Kindle Could Reader uses the HTML5 web standard to let users read e-books from their Kindle library from the Safari browser or Google's Chrome browser on their desktops or tablet, including the iPad.Support for Internet Explorer, Firefox and the Blackberry Playbook will be launched later this year.The app has a button linked to the Kindle Store, which was removed recently from the Kindle apps for iPad and iPhone.The move is taken as an answer to Apple's latest App Store restrictions, which banned developers to have any external links for purchasing digital books or subscriptions in the app, unless they give Apple a 30 percent cut from the in-app sales.Besides Amazon, Barnes & Noble, Google Books and Canadian e- book seller Kobo have also altered their iPad and iPhone apps to comply with the rules.Meanwhile, publishers and retailers have been developing web- based HTML5 apps to sidestep Apple for more control, which is an approved-of technology for iOS devices.The Financial Times, Kobo and video-on-demand service Vudu have recently launched their HTML5 app to avoid paying Apple a 30 percent cut.Industry watchers said it is unknown how Apple will deal with such apps. It would be easy for Apple to disable Web apps in the iPad's Safari browser, but the company would certainly face some backlash, said tech media website CNET.