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The US Food and Drug Administration approved two cancer treatments, Vitrakvi and Xospata, this week after expedited reviews.Vitrakvi, approved Monday, is "a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker)."The FDA said in a statement that it is the second approved cancer treatment that is based on a tumor biomarker instead of the place in the body where the tumor originated.Vitrakvi will be used for the treatment of solid tumors that have an NTRK (neurotrophic receptor tyrosine kinase) gene fusion that do not have a known resistance mutation, that are not metastatic or where surgical removal is likely to lead to severe morbidity, and that have no alternative treatments or have progressed after treatments.NTRK genes are rare but occur in many types of cancer, the FDA said, such as mammary analogue secretory carcinoma and infantile fibrosarcoma.Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.Alongside the tablets, the agency also approved a diagnostic to detect the mutation."Approximately 25 to 30 percent of patients with AML have a mutation in the FLT3 gene. These mutations are associated with a particularly aggressive form of the disease and a higher risk of relapse," Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence, said in the statement.AML is a rapidly progressing cancer that affects the numbers of normal blood cells and calls for continuous transfusions, the FDA said.Both treatments were granted Priority Review designation.Priority Review, established in 1992, means the FDA aims to review the drug or treatment within six months, opposed to 10 months for a standard review."A Priority Review designation will direct overall attention and resources to the evaluation of applications for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications," the FDA says.Both treatments also received?orphan drug?designation, a status granted to drugs for rare diseases or conditions. 2261

The stairs in the entrance of the house used as the home of psychotic killer Buffalo Bill in the 1991 film "The Silence of the Lambs" is seen for sale on Monday, Jan. 11, 2016 in Perryopolis, Pa. Scott and Barbara Lloyd listed the house last summer, but they've dropped the asking price from 0,000 to 0,000. 321

The Trump administration announced Wednesday plans to remove 12,000 US troops from Germany with some being returned to the United States, and others being relocated to other NATO allies.The Department of Defense says that 5,600 troops will be repositioned to other NATO nations, while 6,400 will be returned to the US.Defense Secretary Mark Esper told CNN that the move to relocate troops will cost in the billions.President Donald Trump said the move was made because Germany is taking “advantage” of the US.“They are there to protect Europe and there to protect Germany and Germany is supposed to pay for it,” Trump said on Wednesday. “And we don't want to be -- the United States has been taken advantage of for 25 years with trade and on the military. It's very simple, they are delinquent. Very simple. And there are other NATO countries also, there are 28 countries “While there have been concerns that removing troops from the region diminishes the US presence in Europe in keeping Russia in check, Esper said that the move will enhance its deterrence against Russia.“The repositioning of our forces in Europe constitutes a major strategic and positive shift, wholly in line with the NDS, and consistent with other adjustments the United States has made within NATO in previous times,” Esper said. “These changes achieve the core principles of enhancing U.S. and NATO deterrence of Russia; strengthening NATO; reassuring Allies; and, improving U.S. strategic flexibility and EUCOM operational flexibility.”The reduced presence in Germany cuts the number of troops stationed there by one-third. 1608

The suspect in the shooting deaths of two people at Central Michigan University is in custody, police reported early Saturday. Police spent most of Friday searching for a 19-year-old person of interest after two people were shot and killed on the campus of Central Michigan University on Friday. Scripps station WXYZ in Detroit is reporting that the victims are the suspect's parents.James Eric Davis Jr. is the suspect in the deaths of his parents James Davis Sr. and his wife, Diva Davis. Davis Sr. is a part-time police officer in Illinois in Chicago. Police later confirmed the identities of the victims.  652

The US Olympic Committee wants to revoke USA Gymnastics' status as the sport's governing body as the organization struggles to recover from the sex abuse scandal involving?Larry Nassar.USOC CEO Sarah Hirshland has offered USA Gymnastics the option of surrendering its status voluntarily.In an open letter Monday to the United States gymnastics community, Hirshland wrote, "We believe the challenges facing the organization are simply more than it is capable of overcoming in its current form."She told the athletes they "deserve better."CNN has reached out to USA Gymnastics for reaction.The announcement comes amid turmoil for the current governing body. Nassar is the former team doctor for USA Gymnastics.Last month, USA Gymnastics lost its second president in two months when former US Rep. Mary Bono stepped down as interim president.Bono had taken over just a month after embattled president and CEO Kerry Perry quit. Perry, who held the job for nine months, was criticized for what many people characterized as inadequate action during the Nassar abuse fallout.Bono came under fire in her first few days. In one instance, a September tweet surfaced of Bono defacing a Nike logo after Nike featured former NFL quarterback and civil rights activist Colin Kaepernick in its advertising campaign. (Nike is a major sponsor of Olympic champion Simone Biles, a megastar for USA Gymnastics.)Biles was critical of Bono. She tweeted: "don't worry, it's not like we needed a smarter usa gymnastics president or any sponsors or anything," Biles tweeted. Others also criticized Bono's tweet as being tone-deaf, saying the suppression of athletes' voices allowed Nassar's abuse to continue.Days after Bono's resignation, former USA Gymnastics head Steve Penny was arrested in connection with accusations he removed documents linked to the Nassar sexual abuse case from the Karolyi Ranch gymnastics training facility in Texas, authorities said. A judge set Penny's bail at ,000.Nassar was already serving 40 to 175 years in Michigan for sexually abusing women and girls under the guise of performing medical treatment when he was indicted in June on charges linked to allegations at the Karolyi Ranch.He faces six counts of sexual assault of a child. Meanwhile, former?USA Gymnastics trainer Deborah Van Horn is facing one count of sexual assault of a child in Texas, prosecutors said. 2403