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LOS ANGELES, July 18 (Xinhua) -- U.S. scientists have proven that oncogenes can change normal cells into stem-like cells, paving the way to a safer and more practical approach to treating diseases like multiple sclerosis and cancer with stem cell therapy.In a collaborative study, researchers from the Keck School of Medicine of the University of Southern California (USC), and the Children's Hospital of Orange County (CHOC) in California and Good Samaritan Hospital Medical Center in New York have successfully converted human skin cells into brain cells by suppressing the expression of p53, a protein encoded by a widely studied oncogene. This suggests that p53 mutation helps determine cell fate -- good or bad -- rather than only the outcome of cancer.Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells.Study findings were appearing Monday on the website of the American Association for the Advancement of Science (AAAS)."The reality may be more complicated than people think," said Jiang F. Zhong, Ph.D., assistant professor of pathology at the Keck School. "What is a stem cell gene? What is a cancer gene? It may be the same thing.""When you turn off p53, people think the cell becomes cancerous because we tend to focus on the bad thing," Zhong said. "Actually, the cell becomes more plastic and could do good things, too. Let's say the cell is like a person who loses his job (the restriction of p53). He could become a criminal or he could find another job and have a positive effect on society. What pushes him one way or the other, we don't know because the environment is very complicated."Stem cells can divide and differentiate into different types of cells in the body. In humans, embryonic stem cells differentiate into three families, or germ layers, of cells. The reasons why and how certain stem cells differentiate into particular layers are not clearly understood. However, from those layers, tissues and organs develop. The endoderm, for example, leads to formation of the stomach, colon and lungs, while the mesoderm forms blood, bone and heart tissue. In its study, Zhong's team examined human skin cells, which are related to brain and neural cells from the ectoderm.When p53 was suppressed, the skin cells developed into cells that looked exactly like human embryonic stem cells. But, unlike other man-made stem cells that are "pluripotent" and can become any other cells in the body, these cells differentiated only into cells from the same germ layer, ectoderm."IPSCs (induced pluripotent stem cells) can turn into anything, so they are hard to control," Zhong said. "Our cells are staying within the ectoderm lineage."Zhong said he expects that suppressing other oncogenes in other families of cells would have the same effect, which could have critical significance for stem cell therapy. Future research should focus on determining which genes to manipulate, Zhong said.The study is slated to appear in the Proceedings of the National Academy of Sciences later this month, according to AAAS.
MANILA, June 14 (Xinhua) -- At least 200 people, mostly children, have been taken to hospitals after allegedly suffering from food poisoning at a birthday party in the northern Philippine province of Bulacan, local newspaper Manila Bulletin reported Tuesday.Most of the victims suffered from stomach and chest pains, diarrhea and vomiting, local health officer Dr. Rizalli Lucas was quoted as saying.The victims claimed the cause of their food poisoning was the spaghetti served during a birthday celebration over the weekend in a village of Calumpit town.James P. de Jesus, mayor of Calumpit, said the situation is now contained and controlled but they still have to implement health measures and to determine the cause of the alleged food poisoning.Police have started investigating the incident.
BEIJING, Aug. 3 (Xinhuanet) -- NASA Tuesday confirmed a 4-foot in diameter sphere debris as a fuel tank that was part of the space shuttle Columbia's electrical power system,according to U.S. news reports.NASA engineers identified the 4-foot piece of spherical debris as one of the18 tanks that held chilled oxygen and hydrogen used by the shuttle's electricity-generating fuel cells.This Aug. 1, 2011 handout photo provided by the Nacogdoches Police Department shows a 4-feet in diameter sphere found in Lake Nacogdoches, Texas on Monday, Aug. 1. Police say low water levels at the lake during the drought have led to recovery of a container-like object that could be from space shuttle Columbia. The shuttle broke apart and burned in February 2003, scattering remnants over East TexasPolice in the city of Nacogdoches, about 160 miles northeast of Houston, said Monday the low water levels of Lake Nacogdoches during the record drought revealed an unexpected object that could be from space shuttle Columbia. The shuttle broke apart and burned as it re-entered the atmosphere on February 1, 2003.The tank will be moved to the Kennedy Space Center, where the rest of the Columbia is stored. Approximately 40 percent of the spacecraft has been recovered.
SAN FRANCISCO, Sept. 13 (Xinhua) -- Intel and Google on Tuesday announced a partnership to enable the world's largest chip maker's architecture on the search giant's products, saying that an Intel chip-based Android smartphone will hit the market in the first half of 2012.In a joint press release, the two companies said the future versions of Android mobile operating system will support Intel's low power Atom processors, in addition to other architectures.At the Intel Developer Forum in San Francisco on Tuesday, Intel Chief Executive Officer Paul Otellini said the Intel smartphone chip is code-named Medfield and based on the company's own PC- based computer architecture.Otellini said multiple vendors around the world will launch the Medfield-based Android smartphones in the first half of 2012.Andy Rubin, senior vice president of mobile at Google, came on stage at the close of Otellini's keynote to hail the joint initiatives between the two companies.Intel has been struggling to get a bite of the booming market of smartphones and tablets. Most of the current mobile devices use chips based on architecture from ARM Holdings, which are considered more power efficient than Intel's products. Nokia had planned to ship smartphones with Intel chips this year, but it shifted to ARM-based phones with Windows Phone 7 system.Otellini said Intel will eventually have an advantage in supplying smartphone chips as the business is not established in terms of the final winner and performance of the products keeps growing.
ISLAMABAD, Sept.4 (Xinhua) -- Pakistan's eastern Punjab province is in the grip of a dengue epidemic with dozens of cases being reported daily at various hospitals across the province, said officials and hospital sources.A report issued by the provincial health department on Friday said that as many as 145 cases of dengue fever in Lahore, the provincial capital, and several other cities have been reported in Punjab over the past three days.The total dengue fever cases in the Punjab are 1,419 since the beginning of this year, out of which 1,358 Dengue patients had recovered and been discharged from hospitals, according to local media.Dengue, an acute febrile disease spread by the bite of the aedes aegypti has been endemic in Pakistan for the last few years. It spreads most often after the rainy season in July and August when pools of standing water serve as ideal mosquito breeding spots.Gravity of the dengue disease was felt at the central level and Prime Minister Yusuf Raza Gilani extended full support to the Punjab government in coping with the growing number of cases of dengue fever.The Prime Minister, who was in Lahore on Friday, directed his Principal Secretary to contact the Punjab government and assist them in taking necessary preventive measures against the Dengue fever. He also asked him to extend offer on behalf of the federal government for provision of any technical expertise to the Punjab government.Acting on reports that the virus was spreading rapidly and that measures to control it had been unsuccessful, Punjab Chief Minister Shahbaz Sharif has presided over series of meetings and ordered the immediate suspension of the Lahore district health officer for failing to control the epidemic.A task force comprising a government minister, health officials and doctors has been set up to review the situation and suggest measures to curb the virus.On the orders of the chief minister, giant advertisements on measures that can be taken to prevent dengue have appeared in the media.People have been advised not to allow water to stand in containers, to use mosquito repellents, spray homes and be particularly vigilant at dawn and twilight when the dengue- carrying mosquitoes bite.This increase in public vigilance and awareness may yet halt the spread of a disease that over the past few weeks has struck across the province, said specialists.Meanwhile, the Health Department spokesman also stressed awareness among the people for prevention, control and treatment of dengue virus. According to him, the symptoms of dengue fever include high fever, severe body pain, itching and red spots, bleeding from nose and teeth and severe pain in the eyes. He said precautions include proper covering of the pots having water, like buckets and drums, and using coils, mats and sprays for eliminating mosquitoes.He further said dengue mosquitoes usually attack early in the morning from 6 a.m. to 9 a.m. and from 4 p.m. to 10 p.m.in the evening. The patients should act upon the advice of qualified physicians only, he maintained.