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SAN DIEGO — A San Diego-based stem cell research institute believes its discovery may have saved the life of a COVID patient on death's doorstep.GIOSTAR infused a 53-year-old man in a coma with Mesenchymal stem-cells taken from an umbilical cord. Prior to that, all other treatments were failing. "He was having a stroke, he was under dialysis, liver function was declining," said Dr. Anand Srivastava, co-founder of GIOSTAR. "Nothing was working."The patient, whose identity is not being released due to privacy laws, had been in a coma in a New Jersey hospital. GIOSTAR got special clearance from the Food and Drug Administration to try the stem-cell treatment. Srivastava said the patient began to recover, gradually over three weeks. "Slowly, his renal and liver function came closer to normal," he said. "He came out from the intubation, and now he is talking."The family, in an interview with GIOSTAR, said they had lost all hope. Srivastava said this treatment could be key as society awaits a vaccine. GIOSTAR is planning to do a double-blind study to confirm its conclusions about its treatment. It says that study should take about three months. 1164

Safety-wise, there’s a lot riding on your tires. But many car owners don’t routinely inspect the rubber they are riding on or know what to look for.“Tires are what connects us to the road, and if they are worn, that will reduce your car’s stability and traction,” says David Bennett, AAA’s manager of repair systems.Here are five situations where experts say changes in your driving conditions, tire wear or damage are common — and easy ways to make your tires last as long as possible.1. You moved to a new place with a different climateIf you’ve recently moved from, for example, Southern California to Colorado, your driving conditions are now vastly different. And switching to winter tiresmight be in your future.But don’t wait for the first storm. If your car starts to swap ends, or spin, that’s “not a fun way to discover that you need different tires,” says Matt Edmonds, executive vice president of online retailer Tire Rack.Ask your new neighbors, or an expert at a tire store, what the locals use to stay safe on the roads. Or you can use an online tire guide and user reviews to choose new tires.2. You hit a pothole, nail or curbWhile you’re checking your tires’ pressure — which you should do at least once each month — run your hand over the tread surface to see if there are any nails stuck in the tire or cuts in the tread or sidewall, Bennett says.If you find a nail, don’t pull it out or you might wind up with a flat tire. Instead, drive to a tire repair shop and get them to pull out the nail and, if necessary, patch it.Often, tires are damaged by running over a pothole or rubbing against a curb while parking, Edmonds says. Look for bubbles or bulges that could indicate a developing problem and result in a high-speed blowout. Damage on the inside of the tire is harder to spot and might require a trip to a tire store for an expert’s inspection.3. Your tires are losing tractionTires that have lost all or most of their tread can feel fine while driving in dry conditions. But once rain or snow hits, they lose traction and braking distances increase, Bennett says.To measure tread depth, insert a quarter into the tread in the center of the tire with George Washington’s head pointing toward the tire. If the tread obscures the top of his head, your tires are in good shape.If the top of Washington’s head is even with the tread, the tires are still safe to drive on, but it’s time to start shopping for new ones, Bennett says.4. You hear tire noise, feel vibration or ‘pulling’These are all indicators that something is wrong either with your tires or, in some cases, with the alignment of your front wheels. As the tread wears, tires can become noisy, according to Edmonds.Tires that wear unevenly can cause a vibration through the car, which is commonly felt through the steering wheel. The car is pulling when it doesn’t track straight, slowly wandering either left or right. This is often caused by misaligned front wheels.5. You bought your tires more than six years agoRubber dries out over time, and even if there’s still plenty of tread, the sidewalls can crack.The date the tires were manufactured is printed on the sidewall and is usually preceded by DOT for the Department of Transportation. The first two numbers stand for the week in the year it was made, and the other two are for the year. For example, if your tire has “1109” printed on it, then it was manufactured in the 11th week of 2009.Edmonds says that tires should not be in continual service for more than six years or, if a car was garaged for extended periods, 10 years from the manufacturer date.Tire care basicsTires are expensive, but if you maintain them correctly, most tires provide reliable service for up to 60,000 miles. Here’s how to keep your tires in good condition so you can drive safely:Buy a tire gauge and pump. Tire gauges typically cost less than . And instead of inflating at crowded gas stations, buy a battery-operated inflation pump for less than and do it at home.Locate your tire pressure level. The correct tire pressure level is usually listed on the yellow sticker often found in the driver’s side door jam.Check your tire pressure at least once a month. To get an accurate reading, check your tires in the morning before you drive anywhere. Tires heat up when you drive on them, and this throws off the inflation amount.Don’t forget your spare tire. Inflate your spare tire if you have one. Many cars now are sold without a spare but have an inflation pump and a can of tire sealant that will, in an emergency, both inflate and seal the leak in your tire.Check your temperature. For every 10 degrees the outside temperature drops, a tire’s pressure will decrease by one pound per square inch. So, if you haven’t adjusted your tire pressure since the summer, you could be riding on underinflated tires that won’t handle as well, will wear more quickly and reduce your fuel economy.Rotate your tires regularly. Doing this will make sure your tires wear evenly and last longer. Your car’s service manual recommends the number of miles you can drive between tire rotations.More From NerdWalletHow to Make Your Car Last 200,000 MilesWhen and How Often to Replace Your TiresAuto Loan Refinance Calculator: How Much Can You Save?Philip Reed writes for NerdWallet. Email: articles@nerdwallet.com. Twitter: @AutoReed. 5357

SAN DIEGO (CNS) -- A 37-year-old man was fatally shot on the sidewalk near a parking garage in downtown San Diego's East Village neighborhood, police said Wednesday.The shooting was reported at around 10 p.m. Tuesday near the parking garage on G Street between 14th and 15th streets that serves the Albertsons grocery store, San Diego Police Lt. Andra Brown said.Officers responded and found a 37-year-old man lying on the sidewalk at the entrance of the parking garage with at least one apparent gunshot wound, Brown said.The victim, whose name was withheld pending family notification, was pronounced dead at the scene, she said."It is early in the investigation and little is known about the circumstances surrounding the man's death," Brown said.Witnesses reported seeing a man wearing a dark, hooded sweatshirt and a black hat run through the parking garage after the shooting, then turn westbound on Market Street, the lieutenant said. A detailed description of the man was not immediately available.Anyone with information about the deadly shooting was asked to call SDPD's homicide unit at 619-531-2293 or Crime Stoppers at 888-580-8477. 1153

SAN DIEGO (CNS) - A blaze broke out Tuesday morning at an unoccupied Mira Mesa house being used as a preschool and caused an estimated 0,000 in damage, authorities said.The fire was reported shortly after 2:15 a.m. at a single-story on Gold Coast Drive near Westonhill Drive, according to the San Diego Fire-Rescue Department.Crews responded to the scene and found flames fueled by a gas line on the outside of the home, the agency reported.The flames spread to the garage, attic and portions of the house before firefighters knocked down the flames within 45 minutes, fire officials said. No injuries were reported and the flames did not spread to any nearby homes.Video from the scene showed firefighters cutting their way into a garage to access the house. A sign in front of the house said the daycare was called "Kiddies Korner Preschool."The preschool serves children ages 2 to 5 and has been in business since 1972, according to its website.The blaze caused an estimated 0,000 in damage to the structure and an estimated ,000 in damage to its contents, fire officials said.The cause of the fire was under investigation. 1143

SAN DIEGO — Democratic Congressman Mike Levin has opened a commanding 20-point lead over Republican challenger Brian Maryott in coastal North County's 49th district, according to a new scientific poll.The ABC-10News Union-Tribune poll shows Levin leading Maryott 56 percent to 36 percent, with the remainder undecided. It's an increase over the 49 percent to 37 percent lead Levin had over Maryott in a prior poll taken in mid-September. The district stretches from Del Mar into parts of southern Orange County."It's all over but the shouting," said political analyst John Dadian, who said the district has become increasingly democratic over the last 15 years. "It was getting bluer gradually, and now, the last election cycle and I believe this one, we're going to see the fruit come to bear."Levin won the 49th District seat in 2018 after Republican Darrell Issa decided not to seek re-election after nearly two decades. Issa is now running for Congress in east county's 50th District, which leans Republican. "We've seen a lot of the communities that have shifted to more in the democratic party since 2016 are these more suburban, well-educated communities like many of the communities in California's 49th," said Stephen Goggin, a lecturer in the political science department at San Diego State University. The poll of 514 likely voters shows Levin getting the support of 68 percent of independents, with Maryott, a San Juan Capistrano councilman, getting just 15 percent of them. Both are getting the bulk of their backing from their own parties. In an interview Tuesday, Levin said he was not taking anything for granted, and that the only poll that matters is the one on election day. "This is the home stretch of an election, all hands on deck, leave no stone unturned. That's the only way I know and that's what we're going to do over the next three weeks," Levin said. Maryott's campaign released a statement saying the race is much closer than what this poll shows. "We see it firsthand, on a daily basis: as more voters uncover Mike Levin’s extreme record, support for Brian Maryott increases significantly. We put our trust in the voters, not polls," the statement said. The SurveyUSA poll reports that 13 percent of respondents already voted, and 63 percent are 100 percent they will. It also shows Joe Biden defeating President Trump in the district, 56 percent to 39 percent. SurveyUSA surveyed 650 voting-age individuals from Oct. 8 to Oct. 12. 2472