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WASHINGTON, Dec. 7 (Xinhua) -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) -- a protein that promotes synaptic plasticity -- and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals."These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.

ULAN BATOR, Dec. 1 (Xinhua) -- Mongolia will continue to curb the spread of HIV and strive to maintain a low prevalence of the AIDS epidemic, a government official said Thursday.Gansukh Battulga, an official with the National Committee on AIDS, told Xinhua that Mongolia is currently an HIV low-prevalence country with a total of 99 people, 15 of whom have died, infected with the virus that causes AIDS."Among the 99 HIV infected cases, 81 percent are men, and the remaining 19 percent are women," Battulga said. "Among the male infected cases, 83 percent belong to MSM (men who have sex with men) group while sex workers account for 54 percent of the female infected cases."The official said the government has launched a variety of programs and tasked the National Committee on AIDS to coordinate all organizations in fighting the epidemic.According to a National Strategy Plan for 2010-2015, Mongolia will strive to maintain its current low HIV-prevalence rate of below 5 percent in the most-at-risk population.

COTABATO, Philippines, Jan. 2 (Xinhua) -- The health authorities declared an outbreak of a deadly rat fever on Monday in the flood-hit areas in the southern Philippines.At least five people were already dead and as many as 200 were diagnosed in the southern city of Cagayan de Oro with leptospirosis, a fatal animal-borne disease that can result in high fever, internal bleeding and organ failure.The latest fatality, an old woman, died late Monday due to complication.Dr. Jaime Bernadas, regional health minister, said they fear the number of patients displaced by typhoon Washi could increase in the coming days.Congressman Rufus Rodriguez has called on people affected by the floods that killed over 1,200 people to avail of the government's vaccination against the deadly disease.The death toll from tropical storm Washi currently stands at 1, 258 people with many still believed missing. Washi brought massive rains, causing flooding in many areas in the Central and Southern Philippines starting last Dec. 16.

WASHINGTON, Nov. 14 (Xinhua) -- Vitamin D levels are significantly lower in patients with recurrent inflammatory spinal cord disease, according to a study published online Monday in Archives of Neurology.Vitamin D is a steroid vitamin that promotes the intestinal absorption and metabolism of calcium and phosphorus. In recent years, low levels of vitamin D have been linked to a variety of autoimmune conditions, including multiple sclerosis (MS). However, the importance of vitamin D in monophasic or recurrent non-MS spinal cord diseases including transverse myelitis and neuromyelitis optica is unknown, according to background information in the article.Transverse myelitis (TM) is a disease of the spinal cord in which there is involvement of the myelin sheath that protects nerve fibers; symptoms include back pain and weakness in the legs. Neuromyelitis optica (NMO) is a disease of the central nervous system that affects the optic nerves and spinal cord.Maureen Mealy, of Johns Hopkins University and colleagues investigated the association between low serum vitamin D levels and recurrent spinal cord disease. They analyzed data on vitamin D levels among 77 patients with monophasic (having only one phase or stage) and recurrent inflammatory diseases of the spinal cord, adjusting for season, age, sex, and race. The study found that vitamin D levels were significantly lower in patients who developed recurrent spinal cord disease."Our findings suggest that there may be an association between lower total 25-hydroxyvitamin D levels in patients with recurrent TM/NMO/ spectrum disorders as compared with their counterparts with monophasic disease," the authors report. They suggest that future studies are needed to further assess the relationship between vitamin D and recurrent spinal cord disease.

BEIJING, Nov. 5 (Xinhua) -- Chinese President Hu Jintao's speech at the sixth Group of Twenty (G-20) Summit has drawn positive comments from the international community, which praised the address for proposals for efforts to maintain world economic growth and financial stability.In the speech delivered at the Nov. 3-4 summit in Cannes, France, Hu put forward a package of proposals urging the world's major economies to work together to promote growth and financial stability."It is imperative that we stand on a higher plane, transcend differences on specific issues, move beyond short-term considerations, and jointly seek ways to overcome the crisis and sustain development," Hu told the summit.Chinese President Hu Jintao gives a speech at the Group of Twenty (G20) summit in Cannes, France, Nov. 4, 2011."At this critical moment, the G-20 must work to address the key problems, boost market confidence, defuse risks and meet challenges and promote global economic growth and financial stability," Hu said.Reporting developments at the G-20 summit, the Reuters news agency quoted Hu as saying in the speech: "As the premier forum for international economic cooperation, the G20 must continue to demonstrate the spirit of standing together in times of adversity and pursuing win-win cooperation. At this critical moment, the G20 must work to address the key problems, boost market confidence, defuse risks and meet challenges, and promote global economic growth and financial stability."Reuters also said Hu hopes to send a clear message of ensuring economic development and boosting stablity to the international community.The French newspaper Le Figaro reported that Hu expressed confidence that Europe could overcome its debt crisis.The website of Estado de Sao Paulo, Brazil's daily newspaper, quoted Hu as saying that China has made contributions to world economic growth, and that an imperative task for the G-20 summit was to maintain economic growth.At the summit, Hu said that a priority for world leaders is to maintain robust economic growth, and called attention to the maintenance of domestic growth in China, which would benefit the world economy, the newspaper reported.The newspaper also cited Hu as calling for advancing reform of the international monetary system in a steady manner, expanding the use of the Special Drawing Rights of the IMF, reforming the SDR currency basket, and building an international reserve currency system with stable value, rule-based issuance and manageable supply.O Globo newspaper of Brazil reported that in the speech, Hu demanded that Western countries stop exerting pressures on emerging economic powers to compel them to appreciate their currencies.The newspaper quoted Hu as saying: "To keep asking emerging markets to revalue their currencies and reduce exports will not lead to balanced growth. On the contrary, it would only plunge the global economy into a 'balanced recession' and make sustainable growth impossible."In a related development, Robert Zoellick, president of the World Bank, issued a statement on the G-20 summit on Friday, saying: "The G-20 today presented an agenda to restore confidence in the global economy through its commitment to reinvigorate growth, create jobs, ensure financial stability, and make globalization more sustainable and inclusive."The global economy is still very much at risk from faltering economies in developing countries, and the Eurozone deal has bought some time, and the challenge is how to use the time, Zoellick said."I believe it would be very useful if the G20 leaders can send a strong signal on follow-through after the Eurozone announcement so as to sustain and build confidence," Zoellick noted.