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SAN DIEGO (KGTV) - Looking for laughs? How about a week's worth of them?From May 24 to June 3, comedians will take deliver laughs during the 5th Annual San Diego Comedy Festival. From local comedians to those currently traveling the globe, profession funny men and women will showcase their talents and compete for prizes.Tickets range from to a VIP pass for 5 for shows at The Comedy Palace, The Lot, Comedy Heights, and other local venues.RELATED: Broadway performances heading to San Diego stages this yearThis year's lineup of comedic talents includes Marc Price, of 80s sitcom "Family Ties" fame, and Roger Kabler, who will headline a special tribute performance as the late comedy icon Robin Williams. A full list of comedians is available online.A variety of shows are on deck as well, from an all-Spanish show to a clean comedy showcase. Comedy fans can also check out improv comedy and workshops. And 80 comedians from across the country will compete for cash in standup showdowns. 1030

SAN DIEGO (KGTV) - Local health care workers are seeing a massive number of at-risk patients through virtual visits amid concerns over COVID-19. “We've gone from having 100 visits a day [by phone or video] to 1,200 visits just yesterday alone, says Dr. Abi Olulade with San Diego's Sharp Rees-Stealy Group. She and hundreds of doctors with Sharp Healthcare are putting a special emphasis on telehealth appointments with patients who are considered at-risk because their immune systems can be weaker. RELATED: Coronavirus Impact: Concern over nurses' protective gear“[Patients] with lung disease, heart disease, diabetes and those that are immuno-compromised so we are focused on our higher risk patients,” she tells 10News.This week, 10News interviewed Dr. David Wetherhold at Scripps Health whose team is also trying to reach that same population through Scripps' telehealth program. It was supposed to roll out over the next 18 months, but with COVID-19, it's compressed into a few weeks. “The immuno-compromised, transplant patients, heart failure patients or cancer patients. [They’re] going to be our initial focus [with] trying to get them the care they need remotely without bringing them out into the community," Wetherhold said.RELATED: In-person EDD services temporarily closed“They are more at-risk of getting severe complications from coronavirus so we want to limit them coming into the office when we can,” adds Dr. Olulade. She wants to remind at-risk patients to stay in communication with their providers about any new symptoms, even if mild, that could warrant a need for further evaluation. If an office visit is required, she tells 10News that they'll prepare accordingly to receive those patients and limit any risks they could face. 1762

SAN DIEGO (KGTV) - It's been months since construction began on eight prototypes for a wall to span the U.S.-Mexico divide. The structures, built by six companies that have largely remained out of the spotlight, faced a barrage of tests by border officials, reportedly including jackhammers, saws, torches and other tools and climbing devices to try and thwart the walls.THE CONTRACTORS...The contractors tasked with building the prototypes were: 474

SAN DIEGO (KGTV) — It's a challenge chickens around the world hope you don't attempt.A Rancho Bernardo man has set a new record for eating Chick-fil-A the most consecutive days in a row — barring the company's usual Sunday closure.Even before the challenge, Mark Mendenhall was a regular at the Carmel Mountain Ranch Chick-Fil-A, with employees dubbing him "Mayor of Chick-fil-A.""I have eaten everything on the menu, except the coffee and tea, I don't like coffee or tea, I've had every sauce," said Mendenhall.RELATED: Chula Vista Chick-fil-A employee saves man's lifeBy day he's a realtor, by dinner he's Mayor. "The food is great don't get me wrong, but it's the people here that make you feel good!" Mendenhall says.Several months ago, he heard about a Georgia man successfully eating Chick-fil-A 100 days in a row, excluding days when the restaurant is closed. "I thought to myself, I could do that! I could totally do that!" said Mendenhall.RELATED: San Diego County woman believes ultrasound image resembles late fatherHis wife, reacting differently."At first, I thought it was a little crazy, and I didn't think he'd stick with it, but then I could tell he was serious about it," said Mendenhall's wife, Laura. On a family trip to Disneyland, Mendenhall actually drove from Disneyland to his Chick-fil-A, ordered his meal, and then went back to Disneyland. "My dear wife asked me, when is all of this going to end?!" Mendenhall laughs.He decided he'd end the challenge when they went on vacation, so his wife promptly planned one to Palm Springs. Throughout the journey, Mark took a picture each day with employees, friends, and strangers, proof of his amazing streak.But his mission had another cause. Mendenhall also helped raise nearly ,000 for the Poway Unified School District Adopt-a-Family program through the challenge. 1846

SAN DIEGO (KGTV) — In the race for a coronavirus vaccine, scientists often say we need more than one winner.That’s in part because different vaccines use different strategies to provoke the immune system, and each strategy has different strengths.Take the inactivated virus vaccine, an approach currently used in the vaccine against the poliovirus. In this approach, scientists take a live virus, kill it with chemicals or heat, and then introduce that viral corpse into a person.There are three groups in the final phase of human trials using inactivated coronavirus, primarily in China, according to a tracker from the Milken Institute.“The immune system can tell the difference between something that's a real threat and something that's not a threat, and so if you get injected with a dead virus your immune system has the tendency to not pay a lot of attention to that,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.The downside of the inactivated virus approach is that it only elicits two out of the three of the parts of the immune system, Dr. Crotty said. It’s capable of producing antibodies and helper T-cells, but not killer T-cells.The modern take on the inactivated virus approach is called a viral vector vaccine.In this strategy, scientists combine elements of the coronavirus with a common cold virus called an adenovirus that won’t make you sick. Since the virus is alive, it can elicit all three kinds of immune responses, Dr. Crotty said.“There are no licensed vaccines right now that use that strategy, but there are all kinds of vaccine trials that have been done around the world with those types [of vaccines] showing that they're straightforward to manufacture. They're very safe,” he said.The University of Oxford is testing a viral vector vaccine for COVID-19 in a Phase 3 clinical trial.Then there are subunit vaccines. These include just a section -- or subunit -- of the virus’ protein.UC San Diego is working on a coronavirus candidate vaccine using this approach.There are subunit vaccines currently on the market for tetanus and other viruses.“Working with proteins is more challenging, just from a laboratory and manufacturing perspective,” Dr. Crotty said.Enter the next phase of vaccine development. Instead of using the virus itself or fragments of it, Inovio Pharmaceuticals is working on a vaccine strategy using just the virus’ genetic information.DNA-based vaccines simply introduce a genetically engineered blueprint of the virus into a person, and the cells do the rest.“Some people get confused about this. They think it’s a genetic vaccine that changes their DNA and becomes part of them, and that’s definitely not the case.” Dr. Crotty said. “They don’t become part of you. Your body chews them up.”Researchers have been working on DNA-based vaccines for about 20 years, Crotty said, but none are currently licensed for use.San Diego-based Arcturus Therapeutics is using an RNA-based approach, along with other companies like Pfizer and Moderna that have entered Phase 3 trials.Messenger RNA reads the DNA instructions and helps translate them into proteins.Dr. Crotty said the DNA and RNA approaches have similar drawbacks and benefits: they’ve never been approved for us, but both can be developed rapidly because they don’t require access to the physical virus.Around the world, there are more than 200 coronavirus vaccines currently in development, according to the Milken Institute. 3459

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