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GENEVA, Aug. 19 (Xinhua) -- The World Health Organization (WHO) and the UN Children's Fund (UNICEF) started an emergency vaccination campaign in all accessible areas of South and Central Somalia, WTO spokesperson Tarek Jasarevic said here on Friday.In July 2011 alone, 1,019 suspected measles cases and 31 related deaths were reported in South and Central Somalia, representing 20 percent of all reported cases for this year.The major factors for a measles outbreak in Somalia are low coverage, malnutrition, population movements, and overcrowed internally displaced (IDP) camps."WHO fears that the measles outbreak could affect a high number of people, especially among the vulnerable IDPs whose overall health is already fragile," Jasarevic said.About 2.5 million children aged between 6 and 15 in 10 regions of South and Central Somalia, including children in Mogadishu, will be targeted during this campaign.

coastline in the U.S. State of California sampled by the state water board harbored fish with mercury in such high concentrations that they shouldn't be eaten by young women and children, a newly released survey has found.Fourteen percent of locations had similarly elevated levels of PCBs, according to the survey published by The Los Angeles Times on Sunday.The most elevated concentrations of mercury and PCBs were found in San Francisco Bay and San Diego Bay, said the survey funded by the state water board.The findings, part of a two-year inquiry that is the largest statewide survey of contaminants in sport fish along the California coast, examined more than 2,000 fish from three dozen species gathered in 2009 from waters near Los Angeles, San Francisco and San Diego, the paper said.The survey highlights the health problem of lingering mercury, a poisonous metal that is found in fish globally, and of PCBs, toxic chemicals the United States banned in the 1970s, the report said.Both substances continue to pose a risk to people who eat fish caught along the California coast because they can lead to nervous system damage and developmental problems in children and can cause cancer, liver damage and reproductive harm, the report quoted researchers as saying."Unfortunately, we're not seeing many areas that are totally clean," said Jay Davis, a senior scientist for the San Francisco Estuary Institute and lead author of the study. But a catalog of where and in what fish the substances abound should help anglers make better choices, Davis said. "With good information, people can reduce their exposure significantly."Sharks had some of the highest levels of mercury because of their unusual tendency to accumulate contaminants in their flesh, while chub mackerel had the lowest levels of contamination, according to the survey.The survey results were used in part to help craft new fish consumption guidelines issued earlier this week for anglers in San Francisco Bay, the first update there by state health officials in 17 years. The advisory identifies shiner perch and other surf perches as unsafe to eat in any quantity and warns young women and children not to eat white sturgeon, striped bass and sharks caught in the bay, The Times said.The buildup of metals and other chemicals in fish is such a problem along the Southern California coast that health officials two years ago expanded the number of fish species on the "do not eat" list from one to five because of high levels of PCBs, mercury and the banned pesticide DDT, the report noted.

WASHINGTON, Aug. 2 (Xinhua) -- The weakness of aging is associated with leaky calcium channels inside muscle cells and a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks, according to a report published Tuesday in the online edition of Cell Metabolism.Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come with heart failure and Duchenne muscular dystrophy."It's interesting, normal people essentially acquire a form of muscular dystrophy with age," Marks said. "The basis for muscle weakness is the same." Extreme exercise like that done by marathon runners also springs the same sort of leaks, he added, but in that case damaged muscles return to normal after a few days of rest. A microscopic view shows smooth muscle cells derived from human embryonic stem cells showing the nuclei (blue) and proteins of the cytoskeleton (green) in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The leaks occur in a calcium release channel called ryanodine receptor 1 (RyR1) that is required for muscles to contract. Under conditions of stress, those channels are chemically modified and lose a stabilizing subunit known as calstabin1.Calcium inside of muscle cells is usually kept contained. When it is allowed to leak out into the cell that calcium itself is toxic, turning on an enzyme that chews up muscle cells. Once the leak starts, it's a vicious cycle. The calcium leak raises levels of damaging reactive oxygen species, which oxidize RyR1 and worsen the leak.The researchers made their discovery by studying the skeletal muscles of young and old mice. They also showed that 6-month-old mice carrying a mutation that made their RyR1 channels leaky showed the same muscular defects and weakness characteristic of older mice.When older mice were treated with a drug known as S107, the calcium leak in their muscles slowed and the animals voluntarily showed about a 50 percent increase in the amount of time spent wheel running. Now in clinical trials for patients with heart failure, the drug is known to work by restoring the connection between costabilin and RyR1.Despite considerable effort to understand and reverse age- related muscle wasting, there are no established treatments available. The new work suggests there may be hope in approaching the problem from a different angle."Most research has focused on making more muscle mass," Marks said. "What's different here is that we are focused not on muscle mass but on muscle function. More muscle doesn't help if it is not functional."

WASHINGTON, June 16 (Xinhua) -- Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage. New research by a team of scientists at the University of Rochester has unveiled an important new mechanism that allows cells to recognize when they are under stress and prime the DNA repair machinery to respond to the threat of damage.Their findings will be published Friday in journal Science. Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage.The scientists, led by biologists Vera Gorbunova and Andrei Seluanov, focused on the most dangerous type of DNA damage -- double strand breaks. Unrepaired, this type of damage can lead to premature aging and cancer. They studied how oxidative stress affects efficiency of DNA repair. Oxidative stress occurs when the body is unable to neutralize the highly-reactive molecules, which are typically produced during routine cellular activities.The research team found that human cells undergoing oxidative stress synthesized more of a protein called SIRT6. By increasing SIRT6 levels, cells were able to stimulate their ability to repair double strand breaks. When the cells were treated with a drug that inactivated SIRT6, DNA repair came to a halt, thus confirming the role of SIRT6 in DNA repair. Gorbunova notes that the SIRT6 protein is structurally related to another protein, SIR2, which has been shown to extend lifespan in multiple model organisms."SIRT6 also affects DNA repair when there is no oxidative stress," explains Gorbunova. "It's just that the effect is magnified when the cells are challenged with even small amounts of oxidative stress."SIRT6 allows the cells to be economical with their resources, priming the repair enzymes only when there is damage that needs to be repaired. Thus SIRT6 may be a master regulator that coordinates stress and DNA repair activities, according to Gorbunova.

CAIRO, July 4 (Xinhua) -- U.S. and Italian archeologists have discovered the oldest description about an Egyptian king (about 3, 200 BC) in Egypt's Aswan, Egyptian Antiquities Minister Zahi Hawass said on Monday.The engravings "traces back to when the Egyptian language firstly recorded in hieroglyphs and tells about a unique complete royal ceremony which was known in the ancient Egyptian era," said Hawass in a statement."The pharaoh appears to be wearing the Upper Egypt crown accompanied by (Horus apostles) at the royal court, " Hawass added.Horus is one of the oldest and most significant deities in the ancient Egyptian religion and was worshipped from at least the late Predynastic period through to Greco-Roman times."This discovery is considered a supplementary one at the site unearthed near in el-Hamdulab site in northern Aswan, archaeologists said.This is one of the latest discoveries in Egypt as the surrounding wall of Betah temple (1550 BC-1070 BC) and a gate traces back to Shabaka king era were unearthed on Saturday in Luxor.

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