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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) — It's already been one year since the San Diego Zoo Safari Park saw the first southern white rhino born through artificial insemination arrive at its park.Edward turned one-year-old on July 28, celebrating with a party at the San Diego Zoo Safari Park’s Nikita Kahn Rhino Rescue Center with his mother Victoria, 8-month-old female calf Future, and her mother Amani."Even though he doesn’t know it’s his birthday, it is very special to see Edward – a healthy, robust rhino - running around, enjoying his special treats," said Barbara Durrant, director of Reproductive Sciences at San Diego Zoo Global. "We aren’t just celebrating his birthday but also are celebrating the significance of his birth."Edward was born last year after hormone-induced ovulation and artificial insemination with frozen semen from southern white rhino Maoto on March 22, 2018. Victoria gave birth 16 months later. Edward's birth was the zoo's first successful attempt to birth a southern white rhino via artificial insemination and a critical step toward recovering its distant cousin, the northern white rhino. Currently, only two northern white rhinos exist in the world and both are female.Researchers believe that a northern white rhino calf could be born from artificial insemination within 10 to 20 years. 1313

SAN DIEGO (KGTV) - Many residents living in and around the polluted Tijuana River Valley expressed frustration this week with a plan to use taxpayer money to fund a campground instead of working on a fix to the raw sewage pouring over the border from Mexico into San Diego County. California Senate Bill 507 was signed by Governor Jerry Brown last month and allotted .5 million towards a campground and only 0,000 to study potential fixes to the sewage.“It seems like it’s the bastard child of San Diego and it just sucks.  It’s not fair,” said Ginger Sacco of the Citizens Against Sewage group.Sacco told 10News they were under the impression the bill, which was backed by Senator Ben Hueso and Assemblyman Todd Gloria, would be used to fight the sewage problem.  Instead, Sacco said they only learned last week most of the money would fund a campground backed by San Diego County Supervisor Greg Cox.“I can’t imagine people in their right mind wanting to camp down here knowing all the sewage and toxins that have been coming through here,” said Sacco.A spokesman for Supervisor Cox emailed 10News a statement:“The .1 million comes from a 1988 State park bond act that was specifically designated by the voters for the purchase of land to expand the Tijuana River Valley Regional Park. At this time, after the purchase more than 1,800 acres, there are no additional lands necessary for inclusion to the Regional Park, therefore, we sought State legislation to slightly shift those park funds for the creation of the park and open space amenities.0,000 of that money was allocated to study potential fixes to the sewage spills on the U.S. side….County taxpayer money designated by the voters for a County park is not the proper funding source for an international water pollution prevention and treatment project costing hundreds of millions of dollars.”A spokeswoman for Senator Hueso said she issued news releases that mentioned the campground element.  Sacco said the residents never saw or heard about the campground until recently.An SB 507 promotional YouTube video featuring Assemblyman Gloria focused heavily on the sewage damage but doesn’t mention the campground.  His spokesman sent 10News a statement:“Assemblymember Gloria has been and remains committed to exploring solutions that will stop the pollution in the Tijuana River Valley. The purpose of the video was to highlight the State’s commitment to funding a feasibility study for the development of infrastructure on the U.S. side of the border.As mentioned in the video…this bill starts us on a path toward a long-term solution. It is worth noting that without SB 507, the State would not be funding a feasibility study. In fact, none of this money would be coming to the Tijuana River Valley.” 2807

SAN DIEGO (KGTV) — If Pfizer's coronavirus vaccine is approved this week, UC San Diego Health anticipates receiving its first allocation of the vaccine next week.The vaccine will be considered on Thursday by the Food and Drug Administration. Once it receives the vaccine, UC San Diego Health says its first vaccinations could occur shortly after."Assuming the U.S. Food and Drug Administration issues an Emergency Use Authorization tomorrow or Friday, we would anticipate arrival of the first allocation of the Pfizer vaccine to UC San Diego Health next week, with the first vaccinations occurring shortly thereafter," a statement from the hospital system said. RELATED: What phased vaccine distribution will look like in San Diego CountyThe hospital system says the process of receiving and distributing the vaccine remains fluid and details still need to be finalized.Who will receive the vaccine first will be based on the CDC's Advisory Committee on Immunization Practices, which recommends health care workers receive the vaccination first, along with residents and workers of nursing homes and long-term care facilities.RELATED: What the FDA's review reveals about Pfizer's COVID-19 vaccinePrioritization of who in those first groups receives a vaccination first will also depend on doses available. But those health care workers who face the greatest exposure to COVID-19 patients will be prioritized.This week, an outside group of vaccine experts will advise the FDA and vote on whether to recommend an emergency use authorization for the drug.FDA scientists independently confirmed Pfizer’s claim that its vaccine is 95% effective after two doses and said they found no serious safety concerns, according to documents released Tuesday.Upon approval, California is set to receive 327,000 doses of the vaccine in the first round of allocation. Of those San Diego County is scheduled to receive 28,275 doses. The second round of vaccine allocation is expected within 3-4 weeks. 1991

SAN DIEGO (KGTV) — Memorial Day serves as a day to stop and remember those service members who have given the ultimate sacrifice.In San Diego, several memorial cemeteries will hold services to honor and commemorate these individuals.Elsewhere throughout the weekend, San Diegans will celebrate those freedoms ensured by military members with Memorial Day weekend events around town.Here's a look at Memorial Day services and events:ServicesFort Rosecrans Memorial DayWhen: May 27; When: Where: Fort Rosecrans National CemeteryA Memorial Day service will be held at Fort Rosecrans to honor fallen service men and women starting at 10 a.m. La Vista Memorial Park Memorial DayWhen: May 27; Where: La Vista Memorial ParkBeginning at 1 p.m., a Memorial Day service will be held at La Vista Memorial Park and Mortuary. Public officials on hand will be serving lunch.Mt. Soledad Memorial Day CeremonyWhen: May 27; Where: Mt. SoledadMemorial Day service will be held at Mt. Soledad at 2 p.m., with a special plaque presentation honoring Doris "Dorie" Miller, the first African-American Navy Cross recipient, awarded for his actions during Pearl Harbor.EventsPort of San Diego Festival of the SeaWhen: May 25 - 27; Where: San Diego Maritime MuseumFor the first time, the Port of San Diego is celebrating the sea and San Diego's 250th anniversary with a new community festival on the waterfront. Festival of the Sea features live performances, an artwork exhibition, and (for the older crew) a special on-board pub on the HMS Surprise.Legacy WeekWhen: May 24 - 27; Where: USS Midway MuseumLegacy Week marks San Diego's Memorial Day commemorations with a wreath laying ceremony, family activities, interactive exhibits, benefit concert with Daughtry, and more for the family, all from the USS Midway Museum. 1804