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Each winter, many people wonder whether its worth getting a flu shot while health officials repeatedly warn against not getting one.Now a new study sheds light on the benefit of doing so. Even when the flu shot is just 20% effective it can still reduce US doctor visits due to illness by an estimated 20 million in a single year, the new report published in the scientific journal PNAS (Proceedings of the National Academy of Sciences of the United States) finds.In addition, vaccination also can prevent thousands of hospitalizations and deaths, the study authors estimated based on the average vaccination coverage rate in the United States."Getting vaccinated against influenza is beneficial to the individual and to the community even when the vaccine is of relatively low efficacy," said Burton H. Singer, co-author of the study and an adjunct professor for the Emerging Pathogens Institute at University of Florida in Gainesville.Caused by viruses, flu is a contagious respiratory illness with mild to severe symptoms that can sometimes lead to death. The flu virus evolves rapidly and new viruses circulate in different parts of the world, so each year scientists must reformulate the vaccine. Add to that an imperfect manufacturing process and even a 'good match' formulation may not be as effective as scientists would like.In fact, the Centers for Disease Control and Prevention estimated just 36% effectiveness for the 2017-18 seasonal vaccine as of February 3. (The season ends in May.)For the new study, Singer and his colleagues created a mathematical model of flu transmission and vaccination to evaluate how much illness is prevented by even a very low effectiveness flu vaccine. The research team found that at the average rate of US coverage even a poor vaccine would prevent a significant amount of illnesses, hospitalizations and deaths.For example, at just 43% coverage (the average rate of Americans who received a flu shot for the years 2012 through 2017), a vaccine with just 20% effectiveness could avert more than 20 million infections or illnesses as compared to not getting the vaccine. In addition, 129,000 hospitalizations and 61,000 deaths could be prevented.Based on the model, if more people got a flu shot, say half of the US population, the same 20% effective flu shot would prevent an additional 3.63 million infections, 21,987 hospitalizations and 8,479 deaths."When a vaccine is fully effective on 50% or more of the people who are vaccinated, you need to primarily focus on vaccinating young children," said Singer. The reason? Children are still building immunity and they pass germs around at school."As efficacy of the vaccine decreases, it becomes increasingly important for the elderly to be vaccinated in addition to young children," said Singer, since the elderly are more likely to develop complications from the flu, such as pneumonia, which can be deadly.The CDC reported a total of 160 flu-related deaths in children and 30,064 flu-related hospitalizations overall?between October 1, 2017 and April 21, 2018. The highest rate of hospitalization occurred among adults 65 years old and older.Richard Webby, a flu scientist who is part of the World Health Organization's advisory board and a member of St. Jude Children's Research Hospital's Department of Infectious Diseases, said "effectiveness estimates go up and down based on a number of factors including match of vaccine and circulating strain and probably other factors we don't fully understand.""The take home message from the past few seasons is that there is much room for improvement," said Webby, who was not involved in the research.Still, more people, particularly the elderly, need to get vaccinated even when the vaccine effectiveness is lower than hoped, Webby said: "This study suggests that even with a less than optimal vaccine there is still much public health benefit that can be achieved if these are used properly and widely." 3992

Disneyland aficionados already know about the exclusivity of Club 33. But for a taste of that Disney high life, non-members can enjoy an exclusive dining experience at the park. While it's not cheap, it certainly fits the price tag.Just upstairs from the park's Pirates of the Caribbean ride sits 21 Royal, sporting a name and setting fit for a Disney princess. The 19th century inspired venue is designed as if Walt Disney himself meticulously crafted the 1960s-inspired location, with gold floral accents and an Empire style feel.The fine dining experience begins at the Grand Californian Hotel & Spa, where guests receive a VIP escort to New Orleans Square. Once inside, signature cocktails are served by 21 Royal butlers and guests are invited to the patio for a reception.Guests are able to explore the lavish location's different rooms before a seven-course dinner.An extravagant table awaits, where Disney says a "fascinating tale unfolds" through food and drink, with chefs leading the storytelling and dining journey tableside.To wrap up the evening, guests head out on a private balcony overlooking the Rivers of America for dessert, and if timed on the right night, the park's night-time entertainment.Now for the price tag. The exclusive night runs a flat fee of ,000, coming out to ,250 a person for a group of 12. The price includes the meal, tax, gratuity, wine pairings, and cocktails.The experience also includes park-hopper admission tickets for each guest and valet parking at the Grand Californian Hotel & Spa.For those interested in the luxury experience, have patience. The exclusive night requires a reservation and is only offered on a limited basis. 1755

EL CAJON (CNS) - A young woman who allegedly stabbed her grandmother in El Cajon, leaving the victim hospitalized with serious injuries, was charged Friday with attempted murder, dissuading a witness and resisting arrest.Elektra Zaya Del Sol, 20, of El Cajon, faces a potential life sentence if found guilty of the stabbing attack that occurred shortly before 10:30 a.m. Wednesday in the 1200 block of North Mollison Avenue.READ: Woman arrested for reportedly stabbing grandmother in El CajonParamedics took the victim, whose name and age were not released, to a hospital for treatment of life-threatening injuries, El Cajon Police Department Sgt. Will Guerin said. After questioning her granddaughter, detectives arrested Del Sol on suspicion of carrying out the assault.Police did not disclose a motive for the assault, though the 911 caller who reported it said it occurred during a burglary, according to Guerin.Police did not disclose a motive for the assault, though the 911 caller who reported it said it occurred during a burglary, according to Guerin.Del Sol, who also faces allegations of using a weapon in the attempted slaying and inflicting great bodily injury on an elder, pleaded not guilty and was being held without bail. She is set to return to court April 17 for a readiness conference. 1313

DOHA, Qatar (AP) — The United States and the Taliban have signed a peace agreement aimed at ending the 18-year war in Afghanistan, America's longest. The signing could help President Donald Trump fulfill a key campaign promise to extract America from its “endless wars.” Under the agreement, the U.S. will begin withdrawing thousands of troops in exchange for Taliban commitments to prevent Afghanistan from being a launchpad for terrorist attacks.If the Taliban meet their commitments, all U.S. troops would leave in 14 months. The U.S. invaded Afghanistan after the Sept. 11, 2001 attacks to overthrow the Taliban, who had hosted Osama bin Laden and al-Qaida as they planned and celebrated the assault.The agreements are considered the first step for talks with Afghan factions, which are likely to be complicated. Under the agreement, the Afghan government would release 5,000 Taliban fighters, but it's unclear whether the government will do that. It's also unclear whether those fighters will abide by any peace deal, the Associated Press reported.The complete withdrawal of American troops would not depend on any specific outcome in talks between Taliban and other Afghan factions, the AP reports.In Qatar, U.S. Secretary of State Mike Pompeo met with the Taliban, where the group has a political office, but did not sign the agreement. The agreement was signed by U.S. peace envoy Zalmay Khalilzad and Taliban leader Mullah Abdul Ghani Baradar.Pompeo told reporters that the U.S. is “realistic” about the deal, but is “seizing the best opportunity for peace in a generation.”The Associated Press contributed to this report. 1639

EL PASO COUNTY, Colo. -- You can't even step foot inside Paul and Jenny Fisch's home without wearing a breathing mask. Their dream home was destroyed after they thought the house was sold."I mean, there was just no words... the feces and the urine spread all over our white cabinets, all over our hardwood floor, it was even on the ceiling - 10-foot ceilings," said Jenny Fisch, the homeowner.The Fischs put their home on the market for 0,000 and the first offer they received was for full asking price. They were elated but there was a catch, the buyers wanted to rent the home with the promise they would close in three months."We were told these people were 100 percent qualified, there was no question about it," said Jenny Fisch.Everything seemed to be fine and they had no reason to doubt the offer. The realtor drafted up a contract with information about the loan and a closing date of January 31, 2018. The deadline came and went without the buyers closing on their home even though they were already living in it."What do we do? The only thing we have left to do is start an eviction," said Paul Fisch.The couple even attempted to work out a new deal with the would-be buyers so they could continue renting and eventually purchase the home. The buyers stopped paying rent and they had no choice but to evict them. It wasn't a quick process. Paul and Jenny Fisch weren't prepared for what they were about to find when they showed up to their home with a sheriff's deputy to finally kick the people out."When she walked out her face was like, 'it's bad," said Paul Fisch.Floors were covered in urine, there was feces everywhere and the smell was overwhelming. The house was absolutely filthy and completely trashed."And I lost it, I just lost it. I was like, 'I don't understand why we have to go through this.' I mean we hired people and now my beautiful dream home is covered in feces and I don't know how we're going to fix it," said Jenny Fisch.The buyer was pre-approved for a loan but only if he completed a program and improved his credit score. The lender said that never happened. This information was not made available to the Fischs and they only found out after the deal fell through.The couple said their agent and the buyer's agent assured them everything was good when they agreed to let the buyers rent. RE/MAX, the buyers realtor, said through a spokesperson that realtors don't qualify buyers and it is up to the lender."It's their fault and nobody wants to help us," said Jenny Fisch.The Fischs tried to filed a report with the El Paso County Sheriff's Office but they were told it was a civil matter. They also attempted to contact Child Protective Services because a child was in the home as well as animal control because seven dogs and three cats were found inside.It gets worse. Their insurance won't cover the damage. A spokesperson for Auto-Owners Insurance said they had no comment on the situation.Now the couple is paying a mortgage on a home they can't live in and trying to figure out how to come up with the funds to pay for repairs. The would-be buyers are nowhere to be found and a reporter has not been able to make contact with them."It was insane to me how somebody could live in such a nice home and in a matter of months, destroy everything," said Paul Fisch. 3362