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WASHINGTON, April 11 (Xinhua) -- In the first clinical trial of gene therapy for treatment of intractable pain, U.S. researchers from the University of Michigan's Department of Neurology observed that the treatment appears to be able to provide substantial pain relief.In a study published online in the Annals of Neurology and seen on Monday, the researchers showed that the novel agent NP2 is safe and well-tolerated. In addition, measures of pain in the treated patients suggested that NP2 may provide a substantial analgesic effect.NP2 is a gene transfer vector that expresses the naturally- occurring opioid peptide enkephalin. In preclinical work in animals, David Fink, chair of the Department of Neurology, and his coworkers had demonstrated that injection of NP2 into the skin reduces pain in models of pain caused by nerve damage, inflammation or cancer.In the clinical trial, 10 patients with unrelenting pain caused by cancer were injected with the gene transfer agent in the area of skin related to the location of pain."The concept underlying this therapeutic approach is that injection of NP2 into the skin results in uptake into the nervous system and the production and release of a pain-relieving chemical in a controlled site in the pain pathway," says Fink. "In the study, patients who received the low dose of vector showed little reduction in pain; patients receiving the higher doses showed a greater than 80 percent reduction in pain over the course of four weeks following treatment."Fink's laboratory has been working on the use of modified herpes simplex virus-based vectors that are taken up by sensory nerves following skin injection to develop therapies for diseases of the nervous system for more than 20 years. Patents related to this technology have been exclusively licensed by Diamyd Medical, a publicly-traded Swedish biotechnology company that sponsored the trial, and the human-grade vector NP2 was produced by Diamyd, Inc, the U.S. subsidiary of Diamyd Medical.A phase 2 trial to compare NP2 to a placebo control has already been initiated under sponsorship from Diamyd.

LOS ANGELES, April 14 (Xinhua) -- Customer complaints of an "uncharacteristic odor" prompted Johnson & Johnson to recall about 57,000 bottles of the prescription anti-seizure drug, Johnson & Johnson announced on Thursday.The recall affects two lots of the Topamax 100 mg tablets made by the company's Ortho-McNeil Neurologics division, Johnson & Johnson said.The drug was shipped and distributed between Oct. 19, 2010 and Dec. 28, 2010 in the United States and Puerto Rico.There were four consumer complaints about an odor believed to be caused by trace amounts of the chemical TBA (2,4,6 tribromoanisole), which is applied to wooden pallets used to transport and store packaging materials, Johnson & Johnson said.The recall is not expected to lead to a product shortage at the market, Ortho-McNeil Neurologics said.Similar complaints of a moldy, musty odor have led to the recalls of millions of bottles of Tylenol, Motrin and Benadryl products earlier.Last month, the U.S. government said it was taking over three Tylenol plants operated by McNeil, and the Food and Drug Administration launched a criminal investigation into safety issues at the factories, CNN reported.

SAN FRANCISCO, March 29 (Xinhua) -- Amazon.com Inc. on Tuesday announced the launch of an on-line music storage service,which enables users to store digital music in the cloud and access it from computers and devices running Google's Android operating system.The new service, called "Cloud Drive," offered customers five gigabytes of free storage on Amazon Web servers for all kinds of digital files, including music, photos, videos and documents. For paid plans, users can purchase storage space starting at 20 U.S. dollars a year for 20 gigabytes.The on-line retailer also launched "Cloud Player for Web" and " Cloud Player for Android." The former allows users to get the media files they stored on Amazon's servers from a Web browser on a Mac or PC. The latter lets users play music they have uploaded on Cloud Drive, computers or a smartphone that runs Android operating system.Analysts said Amazon is stepping up its rivalries with Apple and Google. Both companies are also working on similar services, allowing users to store their music on-line and access it from any compatible device.Media reports said that Apple was pushing hard to launch a digital music locker service in April. Google was also reported to be testing its own digital locker service but it still needs to make agreements with major music labels.

DAVOS, Switzerland, Jan. 27 (Xinhua) -- A policy of more trade and greater openness to the rest of the world has brought significant benefits to China and greater market opportunities to its trading partners, the head of the World Trade Organization says."I don't think there is any question that China joining the WTO has been a very good thing for China and for the WTO and its members," WTO Director General Pascal Lamy said in an interview with Xinhua.The WTO chief was expected to join the forum "China's Impact on Global Trade and Growth" on the sidelines of the World Economic Forum annual meeting held in this Swiss alpine town."In joining the WTO, China successfully underpinned a policy of what had been 20 years of progressive openness," Lamy said.Adherence to economic reforms through international commitments ensured that China would stay on the path of openness, he noted, adding that the policy has helped the country economically, politically and socially.Lamy stressed that China has done a "remarkable job" in reducing poverty, which is an important task for the country, along with registering double-digit growth, thus becoming the world's largest manufacturer and the second largest economy.Apart from enhanced market access with its trading partners and more equal treatment in global trade, WTO membership also has allowed China to gain access to the organization's dispute settlement system, Lamy said.According to a WTO report issued in December, as the world's biggest exporter, China ranks first in receiving anti-dumping (AD) investigations, with 23 new AD initiations directed at its exports in the first half of 2010.In recent rulings arbitrated by the WTO Dispute Settlement Body (DSB), China has won a poultry dispute against the United States, and a steel fastener case against the European Union.Being a WTO member, "China would have a seat at the table as negotiations commenced on the trade rules for the 21st century," Lamy said, referring to the decade-long Doha round of global trade negotiations aimed at building the next generation trading system.Even more importantly, for China, participation in the global system of rules and discipline greatly boosted investors' confidence and helped facilitate foreign direct investment in China, he said.On the other side of the coin, China's integration into the world trading system has given enormous driving force to the global economy and market opportunity to its trade partners.

LOS ANGELES, May 1 (Xinhua) -- Middle-aged adults who sleep too less or too much may be more likely to suffer cognitive decline, a new study suggests.According to the study, less than six hours of sleep each night is considered too little and more than eight hours as too much for middle-aged adults.The study, conducted by researchers at University College London Medical School, was published May 1 in the American medical journal Sleep.The researchers conducted the study in two periods -- the 1997- 1999 period and the 2003-2004 period. The participants were asked how many hours they slept on an average week night, and were asked the same question in 2003-2004 after an average 5.4 years of follow-up.The researchers compared those who reported changes in their sleep patterns with people whose sleep duration stayed the same over the course of the study.In the follow-up, each individual was given a battery of standard tests to assess his or her memory, reasoning, vocabulary, global cognitive status and verbal fluency.The study findings show that women who slept seven hours per night had the highest score for every cognitive measure, followed by those who had six hours of sleep. For men, cognitive function was similar for those who reported sleeping six, seven or eight hours.However, less than six hours of sleep -- or more than eight hours -- were associated with lower scores."Sleep provides the body with its daily need for physiological restitution and recovery," explained Jane Ferrie, a senior research fellow in the department of epidemiology and public health at the school. "While seven hours a night appears to be optimal for the majority of human beings, many people can function perfectly well on regular sleep of less or more hours."However, since most research has focused on the effects of sleep deprivation on biological systems, it is not yet fully understood why seven hours is optimal -- or why long sleeping appears to be detrimental, Ferrie said."Chronic short sleep produces hormones and chemicals in the body which increase the risk of developing heart disease and strokes, and other conditions like high blood pressure and cholesterol, diabetes and obesity," she added.