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SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) — As more and more Americans turn to their favorite online retailers this holiday season, banks are reminding shoppers to remain vigilant for thieves on the web.According to Adobe Analytics, shoppers spent about billion online this Black Friday, and another .8 billion on Cyber Monday the following week — making it the largest shopping day online in history.While online thieves have always been a threat to shoppers, there are even more shoppers at risk today."It's more important than ever to be hyper-vigilant and protect yourself from fraud," Sarah Bilyeu with San Diego County Credit Union told 10News reporter Vanessa Paz. "We're seeing a lot more people shopping online because of stay-at-home orders and during holidays, it'll increase and it's something vital to your overall financial wellness."Bilyeu recommends shopping with websites and companies that you're familiar with or that you've already been a customer of in the past.And while it may seem simple to some, customers are also reminded to avoid clicking on unfamiliar links or opening emails they don't expect. In 2019 alone, Experian reported identity theft had resulted in .9 billion in losses.If shoppers aren't careful, a hard year on finances can be stressed with identity theft."If you are unsure, call the institution that's sending the message to check if it's a valid message," says Bilyeu. "When shopping online or engaging where you give credit card numbers, make sure you're on a secure and not public WiFi."SDCCU has more tips to keep in mind when shopping online. 1582

SAN DIEGO (KGTV) - Crowds have been sparse at Balboa Park since the start of the coronavirus pandemic, but that doesn't mean the park hasn't been busy."The change in Balboa Park is evident. The change in Balboa Park is important," says Peter Comiskey, the Executive Director of the Balboa Park Cultural Partnership.Comiskey says nearly every museum in the park has used the unexpected downtime to refresh their exhibits or renovate their facility. That includes large-scale renovations at the Timken and Mingei Museums."While they've been closed, they've been taking advantage of, in some cases, completely removing all of their pieces and reworking their entire buildings," says Comiskey.RELATED: Observation Wheel could bring people back to the parkBut it's not just museums. The 100-year old carousel is getting refurbished. Crews are almost finished building an observation deck around the Morton Bay Fig Tree. Five new cottages in the International Village are about to open up, housing 9 new cultural groups. And the City of San Diego is finally doing a lot of deferred maintenance on water and sewer lines.RELATED: Carousel work continues through PandemicThe biggest difference and the biggest projects are underway in the park's South Palisades area. Work is almost complete on a brand new pedestrian plaza, replacing half of the parking lot in front of the Air and Space Museum.RELATED: City to replace 144 parking spaces with plazaNext to the plaza, the Comic-Con Museum still plans a grand opening in the summer of 2021 in the building that used to be the Hall of Champions.And the Save Starlight group just revealed new plans for a complete overhaul of the Starlight Bowl theater, which has been closed since 2010."The placement of the museum in that area couldn't have been any better," says Melissa Peterman, the VP of Development for the Comic-Con Museum. "We want to do our part to help elevate the Palisades and revitalize it in the way that Plaza de Panama was."The pandemic allowed the Comic-Con Museum to get a head start on their online offerings, while still working on building renovations and exhibit planning.The Starlight plans show new terraced lawn seating, nature gardens, walking trails, and smaller stages surrounding the main bowl.Save Starlight President Steve Stopper says work is already underway on some of the smaller parts of the renovation, so they can build excitement over the coming months."It creates a window for people to get behind the idea," he says. "They can see this is really viable for the future."Stopper says it's an exciting time to be around the park, as it adds more gems to the Crown Jewel of San Diego. 2669

SAN DIEGO (KGTV) -- Authorities are investigating after an inmate died at the George Bailey Detention Facility. According to the San Diego County Sheriff’s Department, deputies were notified that an inmate identified as 63-year-old Dennis Lee Curry needed medical help inside his cell on May 11. Deputies say when they arrived, Curry complained of pain to his head and chest, but had no visible injuries. Curry was taken to a local hospital where his condition worsened and he was placed on life support before he died on the morning of May 13. Following an autopsy, it was discovered that Curry died of natural causes. The Sheriff’s Department’s homicide unit was called in to investigate, as they do with all in-custody deaths. Curry was in custody for outstanding warrants related to prior DUI and drug-related charges, according to the department. 860

SAN DIEGO (KGTV) - Busy families can get help from the United States Department of Agriculture, which has tips for stretching your food budget and eating well when money is limited.Buy in season: Sticking to fruits and vegetables that are in season can lower the cost and add to the freshness.Go back to basics: Convenience foods like pre-cut fruits and vegetables and take-out meals often cost more.Meal prep: Make a large batch of favorite recipes and freeze in individual containers. If you use them throughout the week, you can avoid spending on take-out meals.Find deals right under your nose: That may include peel-off coupons on items, signs on aisle shelves, or coupons with your receipt.Search for coupons: Don’t overlook your junk mail! Many stores still mail coupons and ads, or you can find them online.Look for savings in the newspaper: Brand-name coupons are found in paper inserts every Sunday. Some stores offer double value on coupons on some days of the week.Join your store’s loyalty program: You can receive savings and electronic coupons when you provide an email addressFind out if your store will match a competitor’s coupon: Many stores will accept coupons for the same item.Get a coupon buddy: Swap coupons you won’t use with a friend.Stay organized: Sort your coupons so they’re easy to find.The USDA has sample two-week menus, recipes and a shopping list that can be used by anyone wanting a healthy diet at a modest price. The USDA created recipes using basic kitchen equipment and made lunches designed to be packable so they can be taken to work or school. 1619

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