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For the first time in more than a decade, a new treatment to improve brain function for Alzheimer’s disease has been submitted to the Food and Drug Administration (FDA) for review.This was after the drug trial was stopped and then a second look revealed some promising results.The Waterhouse family has seen the impact of Alzheimer’s firsthand.Gina and Steve Waterhouse have been a team most of their lives. They’ve been married for 43 years and ran several businesses together. Then in 2016, things started to change. Gina didn’t notice anything but employees at the family's businesses did.“I wasn't remembering some of the stuff I was supposed to be doing,” said Gina.Gina was diagnosed with early Alzheimer's disease that year.“They said, 'well you can come back in a year. We will check and see how you're doing, or we have a drug trial if you're interested,'” said Gina.Gina and Steve spent the next two and a half years at the Mayo Clinic, where Gina eventually got high doses of the drug aducanumab.Steve started to notice Gina was remembering more things and reported it back to doctors.“He just smiled and said, 'let me tell you what we're seeing. We're seeing cognitive improvement. And it’s the first time in my career.' These doctors said in their career that we've ever seen it,” said Steve.“He was so excited,” said Gina.Then in 2019, the drug trial suddenly ended. Gina says she felt like she’s gone downhill a little since it did.Rebecca Edelmeyer, PhD, with the Alzheimer’s Association, says the trial stopped early based on a futility analysis.“It was a statistical analysis that was done by the Biogen team, predicting that the trial would not actually be successful,” said Edelmeyer.Edelmeyer says then upon a second look at the trial data, they found that those people on the highest dose of the drug were seeing improvement in their brain function. She called it a very important moment for the Alzheimer’s research community.Now, the government will determine whether or not the drug is safe and effective enough to use.Steve mentioned there were some possible side effects like bleeding of the brain, but Gina did not experience any.Meanwhile, Gina can no longer take the drug. She and Steve have decided to retire.“We just decided tomorrow has to come today and we're having a great time. We're loving life,” said Gina.You can learn more about aducanumab here. 2394

For 20 minutes, the Southwest Airlines jet was a normal flight from New York to Dallas with 149 people aboard.The plane was flying at 32,500 feet Tuesday morning as passengers settled in for the three-hour flight.Suddenly, the alarms blared in the cockpit as what sounded like explosions boomed from the left side of the plane. Oxygen masks swiftly dangled from the ceiling.What followed was a terrifying sequence of events that ended with one woman dead, seven people injured and an emergency landing at Philadelphia International Airport.'Everybody was going crazy'Southwest Airlines Flight 1380 took off from LaGuardia at 10:43 a.m., and landed in Philadelphia about 11:20 a.m., federal officials said.The Boeing 737 was headed to Dallas with 144 passengers and five crew members . For about 20 minutes, everything seemed calm. Then what sounded like an explosion suddenly jolted the plane, passenger Marty Martinez said."I heard a loud boom and about five seconds later, all the oxygen masks deployed," he said. "I immediately knew something was wrong. It just didn't register what could have been."Something in the engine broke apart midair and burst through the window, passengers said. The shattered window partially sucked a woman out of the plane as passengers struggled to pull her back in."Everybody was going crazy, and yelling and screaming," Martinez said. "As the plane is going down, I am literally purchasing internet just so I can get some kind of communication to the outside world."Objects flying outAs the plane quickly descended, passengers close to the woman scrambled to hold her tight. Others stuffed clothes and jackets into the gaping hole on the window, said Martinez, who was sitting two rows away from the woman. Those items got sucked out of the plane, too, he said."We could feel the air from the outside coming in, and then we had smoke kind of coming in the window," Martinez said.In the chaos, it was hard to hear anyone. Flight tracking website FlightRadar24 estimated the plane descended from 31,684 feet to 10,000 feet in a little over five minutes."It was very loud, so announcements from the pilot or any other crew would not have been heard," passenger Amy Serafini said.Passenger Matt Tranchin watched the commotion as people tried to help."Everyone kind of descended on where this hole was," he said. He thought about his family, and whether he'd see them again."That I'll never live to see my son born. That I'll never be able to say goodbye to my wife, say goodbye to my parents. But I am. I feel really very fortunate for that," he told CNN affiliate WPVI.Nurse performs CPRAfter trying to pull the woman back for several minutes, a man in a cowboy hat and a second man finally got her back in her seat, Serafini said.A nurse aboard the flight volunteered to perform CPR."I went back and we started CPR on the lady, which we continued for about 20 minutes. We were still doing CPR when the plane landed," said nurse Peggy Williams. "We made every effort that we could possibly make to save this woman's life."Martinez said it was a rough landing, and he wasn't sure if the plane was going to crash. The jet could have been landing on a freeway or a skyscraper for all he knew, he said."I didn't know if we were going to be running into a building. I didn't know what state the plane or even the pilot was in, if we were in condition to land," he said. "Finally when we ... came to a halt, of course, the entire crowd was (in) tears and people crying and we were just thankful to be alive."Air traffic callBefore the plane landed, the pilot asked the air traffic controller to send medics to meet it."Injured passengers OK, and is your airplane physically on fire?" the air traffic controller asked."No, it's not on fire, but part of it is missing. They said there's a hole and that someone went out," the pilot responded."Um, I'm sorry, you said there was a hole and somebody went out? Southwest 1380, it doesn't matter we will work it out there," the air traffic controller said.The air traffic controller asked other planes to prepare for the airport to be shut down.The investigationThe National Transportation Safety Board said a preliminary look at the engine shows one of its 24 fan blades was missing.A first look showed evidence of metal fatigue where the blade attached to a hub, according to Chairman Robert Sumwalt of NTSB.The crew reported damage to one of the aircraft's engines as well as the fuselage and a window, the Federal Aviation Administration said.Southwest CEO Gary Kelly said the plane was inspected Sunday, but he had no details on what parts were examined. "I'm not aware of any issues with the airplane or any issues with the engine involved," he said."This is a sad day and our hearts go out to the family and the loved ones of the deceased customer," he said. "We will do all that we can to support them during this very difficult time."The woman killed was identified as Jennifer Riordan, 43, according to CNN affiliate KOAT. It said she worked for Wells Fargo in Albuquerque, New Mexico. Southwest said it's the first in-flight death in company history.Flight recorders found The flight data recorder and the cockpit voice recorder have been sent to Washington, Sumwalt said. The flight data recorder showed the plane was at 32,500 feet when the engine failed about 20 minutes into the flight.The cowling for the engine was found about 70 miles from where the plane landed.In August 2016, a Southwest Airlines jet flying from New Orleans to Orlando was forced to make an emergency landing in Pensacola, Florida, when an engine failed.The-CNN-Wire 5632

Former White House national security adviser Mike Flynn and his son are alleged to have been offered as much as million to forcibly remove from the US a Muslim cleric wanted by Turkey, The Wall Street Journal reports.The Journal reported the FBI questioned at least four people in regards to a mid-December meeting in New York at the "21" Club. Discussions between Flynn and Turkish representatives supposedly took place there, according to the Journal.The Journal said the people who described the alleged proposal didn't attend the December meeting and didn't have direct knowledge of the details. There's no indication that money changed hands or that an agreement was made.The discussions allegedly included how to transport Fethullah Gulen, a Muslim leader who Erdogan has accused of being behind a failed military coup to overthrow him, on a private jet to the Turkish prison island of Imrali.The Journal reported attorneys for Flynn and his son declined comment.CNN reported earlier this week that special counsel Robert Mueller's investigators are examining Flynn's alleged participation in discussions about the idea of removing the cleric who has been living in exile in Pennsylvania. In the past, a spokesman for Flynn has denied that such discussions occurred.CNN also reported that Flynn has expressed concern about the potential legal exposure of his son, Michael Flynn Jr., who, like his father, is under scrutiny by Mueller, multiple sources familiar with the matter tell CNN.Former CIA Director James Woolsey told CNN in March about an earlier meeting in September 2016 where Flynn also met with representatives of the Turkish government and discussed potential ways to send a foe of Turkey's president back to face charges in that country.Woolsey claims that those present discussed sending Gulen back to Turkey to face charges -- possibly outside the legal US extradition system."What I saw and heard was sort of the end of the conversation -- it's not entirely clear what transpired because of that," Woolsey said on "CNN Tonight" with Don Lemon. "But it looks as if there was at least some strong suggestion by one or more of the Americans present at the meeting that we would be able, the United States would be able, through them, to be able to get hold of Gulen, the rival for Turkey's political situation."At the time, a spokesman for Flynn denied the allegation."The claim made by Mr. Woolsey that General Flynn, or anyone else in attendance, discussed physical removal of Mr. Gulen from the United States during a meeting with Turkish officials in New York is false," Flynn spokesman Price Floyd said in a statement at the time. "No such discussion occurred. Nor did Mr. Woolsey ever inform General Flynn that he had any concerns whatsoever regarding the meeting either before he chose to attend or afterwards."If proven, the alleged plan to kidnap the cleric with the aid of foreign money directly violates US criminal code and could result in up to a 20-year sentence for the Flynns, according to Michael Zeldin, a CNN legal analyst."Under this statute, both domestic kidnapping in violation of US law, and if it was a crime in Turkish law, both would be specific unlawful activities, so anyone who engages in the effort to bring money into the US for the purpose of kidnapping another violates the statute. That's a 20-year felony," Zeldin said.If the cleric were to die once in Turkish hands, that could mean a life sentence for the pair, Zeldin said."This probably has nothing to do with the Trumps, but this is a very serious crime," he said. "Theoretically, if they did this international kidnapping and the Turkish government killed this guy, that could be a life sentence for the Flynns. You don't really want to be involved in a scheme like this, no matter how broke you might be."The Mueller investigation into the Flynns is part of an overall probe into the Trump campaign's involvement with Russia.Flynn is also under legal scrutiny by Mueller's team for undisclosed lobbying that he did during the presidential campaign on behalf of the Turkish government, according to sources familiar with the matter. It's against the law to lobby in the United States on behalf of a foreign government without informing the Justice Department.  4289

Former Arizona Diamondbacks player, Matt Mantei, was reportedly arrested in Michigan Tuesday for assault and battery.According to TMZ Sports, Mantei, 44, was arrested and booked into Berrien County Jail.Details surrounding his arrest were not immediately available but Mantei remained behind bars as of Wednesday morning, TMZ says.Mantei played 10 seasons in the big leagues for the Diamondbacks, Red Sox and Marlins. On July 8, 1999, he was traded by the Florida Marlins to the Diamondbacks where he remained through the 2004 season. 552

Former President George H.W. Bush's family intentionally planned a state funeral for him that will avoid criticism of President Donald Trump despite the long-running animosity between the two families, The Washington Post reported Monday night.Trump and Bush's son, Jeb Bush, engaged in a vitriolic primary rivalry during the 2016 campaign, and Trump has mocked and criticized the legacies of both Presidents Bush. A funeral that avoids criticizing Trump would be in contrast to the September memorial for Sen. John McCain, which was marked by implicit references to Trump and his behavior as president.The Post, citing a former administration official, said that the Bush family contacted the White House this past summer to make it clear that the President would be welcome at the funeral and, according to the paper, to "assure him that the focus would be on Bush's life rather than their disagreements."PHOTOS: President George H.W. Bush through the ages 966