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The first experimental COVID-19 vaccine in the U.S. is on track to begin a huge study next month to prove if it really can fend off the coronavirus, while hard-hit Brazil is testing a different shot from China.Where to do crucial, late-stage testing and how many volunteers are needed to roll up their sleeves are big worries for health officials as the virus spread starts tapering off in parts of the world.Moderna Inc. said Thursday the vaccine it is developing with the National Institutes of Health will be tested in 30,000 people in the U.S. Some will get the real shot and some a dummy shot, as scientists carefully compare which group winds up with the most infections.With far fewer COVID-19 cases in China, Sinovac Biotech turned to Brazil, the epicenter of Latin America’s outbreak, for at least part of its final testing. The government of S?o Paulo announced Thursday that Sinovac will ship enough of its experimental vaccine to test in 9,000 Brazilians starting next month.If it works, “with this vaccine we will be able to immunize millions of Brazilians,” said S?o Paulo′s Gov. Joao Doria.Worldwide, about a dozen COVID-19 potential vaccines are in early stages of testing. The NIH expects to help several additional shots move into those final, large-scale studies this summer, including one made by Oxford University that’s also being tested in a few thousand volunteers in Brazil.There’s no guarantee any of the experimental shots will pan out.But if all goes well, “there will be potential to get answers” on which vaccines work by the end of the year, Dr. John Mascola, who directs NIH’s vaccine research center, told a meeting of the National Academy of Medicine on Wednesday.Vaccines train the body to recognize a virus and fight back, and specialists say it’s vital to test shots made in different ways — to increase the odds that at least one kind will work.Sinovac’s vaccine is made by growing the coronavirus in a lab and then killing it. So-called “whole inactivated” vaccines are tried-and-true, used for decades to make shots against polio, flu and other diseases — giving the body a sneak peek at the germ itself — but growing the virus is difficult and requires lab precautions.The vaccine made by the NIH and Moderna contains no actual virus. Those shots contain the genetic code for the aptly named “spike” protein that coats the surface of the coronavirus. The body’s cells use that code to make some harmless spike protein that the immune system reacts to, ready if it later encounters the real thing. The so-called mRNA vaccine is easier to make, but it’s a new and unproven technology.Neither company has yet published results of how their shots fared in smaller, earlier-stage studies, designed to check for serious side effects and how well people’s immune systems respond to different doses.Even before proof that any potential vaccine will work, companies and governments are beginning to stockpile millions of doses so they can be ready to start vaccinating as soon as answers arrive.In the U.S., a program called “Operation Warp Speed” aims to have 300 million doses on hand by January. Under Brazil’s agreement with Sinovac, the Instituto Butantan will learn to produce the Chinese shot.___AP journalist Marcelo Silva de Sousa contributed to this report.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3499

The following column is written by Elie Honig, a former Assistant U.S. Attorney for the Southern District of New York.Last week, notorious Boston mafia boss Whitey Bulger was killed inside the high-security federal Hazelton Penitentiary in West Virginia. Bulger had just arrived at Hazelton the day prior. According to the Boston Globe, federal authorities are now focused on Fotios "Freddy" Geas, a former Massachusetts-based mafia hitman, as Bulger's killer.In 2011, I tried and convicted Geas, along with his brother Ty Geas and their mafia boss Arthur "Artie" Nigro for a string of vicious murders, murder attempt and murder conspiracies they committed in Massachusetts and New York. All three received life sentences. 740

The Cinemark Theater in Towson, Maryland was packed with people who came for what they call the biggest movie of the year, and then they were turned away."I arrived at the theater and they were telling me all of the 'Black Panther' shows were canceled," Miya Henry said.Not what moviegoers who've been waiting months for Marvel's highly anticipated "Black Panther" film wanted to hear."We've been all excited, I took off of work tonight so I'm a little disappointed," Brandie Garland said.Several showings were turned away because of what moviegoers say was a malfunction with the film."There was a long refund line so everyone who purchased a ticket in support of the movie are now getting their money back," Garland said. "Originally when we got to the box office they were saying they were having some difficulties, but they said it wouldn't be an issue they were pretty sure the movie was going to show."But there was an issue according to dozens of tweets we found where Cinemark openly apologized for the inconvenience.We’re very sorry for this inconvenience. Was a theatre manager able to assist with a refund? If not please let us know more at https://t.co/tfn4khl2Bc or call at 1-800-246-3627 so we can further assist. Thank you and we do apologize again.— Cinemark Theatres (@Cinemark) February 16, 2018 1341

The Food and Drug Administration is investigating an outbreak of Listeria that has killed at least one person.The FDA, CDC and public health officials are looking into ten cases of Listeria monocytogenes infections reported in Florida, Massachusetts and New York. One person has died, the only available information is that the person lived in Florida.Genome sequencing of the Listeria bacteria isolated from those infected shows the ten people in this outbreak are more likely to share a common source of infection, according to the FDA. Samples were taken from patients between August 6 and October 3.In interviews with nine of the infected people, they all reported eating Italian-style meats recently, like salami, mortadella, or prosciutto, according to the FDA.Public health investigators have not found a common type of deli meat or common supplier among the patients at this time.The patients in this outbreak range in age from 40-to-89 years old, and all of them needed to be hospitalized.Listeria can cause different symptoms, depending on the person and part of the body affected, according to the Centers for Disease Control and Prevention. Symptoms include headache, stiff neck, confusion, loss of balance, fever and muscle aches. 1251

The Daily Mail released leaked footage of the fatal Memorial Day arrest of George Floyd, who died while in the custody of Minneapolis Police.The Daily Mail did not indicate how it received the leaked body worn camera videos of the arrest. Prosecutors told CNN they are working to find the source of the leak. Several media outlets have sued prosecutors in order to gain access to the body-worn camera footage from the officers."The prosecution team is not the source of the leak. We will continue to take the strictest precautions to ensure a fair trial," Minnesota Attorney General Keith Ellison said.The Daily Mail said the footage was taken from the body cameras of Thomas Lane and Alex Kueng. Lane and Kueng along with Derek Chauvin and Tou Thao were fired as officers and criminally charged for Floyd’s death. Chauvin is facing the most serious charges, which include second-degree murder. The other three former officers are being charged with aiding and abetting a second degree murder. Chauvin was the officer that held a knee to Floyd’s neck for several minutes, leading to his death.The footage shows officers pointing weapons at Floyd in order to get him to exit his vehicle and put up his hands. The video then shows Floyd pleading with officers not to shoot him.“I'm not going to shoot you,” Lane says.The footage showed Floyd in an apparent struggle with officers as officers repeatedly asked Floyd to sit.As Chauvin laid on Floyd’s neck, Floyd could be heard telling officers, “Tell my kids I love them. I'm dead.”To view the full video, click here. 1572