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The US Food and Drug Administration approved two cancer treatments, Vitrakvi and Xospata, this week after expedited reviews.Vitrakvi, approved Monday, is "a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker)."The FDA said in a statement that it is the second approved cancer treatment that is based on a tumor biomarker instead of the place in the body where the tumor originated.Vitrakvi will be used for the treatment of solid tumors that have an NTRK (neurotrophic receptor tyrosine kinase) gene fusion that do not have a known resistance mutation, that are not metastatic or where surgical removal is likely to lead to severe morbidity, and that have no alternative treatments or have progressed after treatments.NTRK genes are rare but occur in many types of cancer, the FDA said, such as mammary analogue secretory carcinoma and infantile fibrosarcoma.Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.Alongside the tablets, the agency also approved a diagnostic to detect the mutation."Approximately 25 to 30 percent of patients with AML have a mutation in the FLT3 gene. These mutations are associated with a particularly aggressive form of the disease and a higher risk of relapse," Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence, said in the statement.AML is a rapidly progressing cancer that affects the numbers of normal blood cells and calls for continuous transfusions, the FDA said.Both treatments were granted Priority Review designation.Priority Review, established in 1992, means the FDA aims to review the drug or treatment within six months, opposed to 10 months for a standard review."A Priority Review designation will direct overall attention and resources to the evaluation of applications for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications," the FDA says.Both treatments also received?orphan drug?designation, a status granted to drugs for rare diseases or conditions. 2261

The University of Texas Athlete Alumni are in absolute opposition of racism in any form and are engaged in meaningful collaboration to enact change. We are united in our support for current student athletes.#UTXAA#ITooAmTexas#BurntOut#WeAreOne pic.twitter.com/B9HTMJ0hde— Fozzy Whittaker (@FozzyWhitt) June 16, 2020 324

The University Hospitals Fertility Clinic in Cleveland is facing dozens of legal actions after the failure in early March of a cryopreservation tank containing approximately 4,000 eggs and embryos belonging to at least 950 families."We currently represent well over 100 clients whose cases we will pursue as individual claims. That number is growing by the day," Cleveland attorney Tom Merriman said Monday.Also Monday, attorney Gloria Allred threw her hat into the ring, announcing litigation on behalf of three Pittsburgh women who are all cancer survivors. 567

The Supreme Court decided on Monday that they will not reexamine a doctrine that protects law enforcement and government officials from being sued over their actions while on the job.The doctrine, which the justices created nearly 50 years ago, gives "qualified immunity" for law enforcement officers, which protects them from frivolous lawsuits CNN reported.The decision comes amid protests over the death of George Floyd, who died while in police custody in Minneapolis.According to CBS News, the courts were to hear one case about a man in Tennessee that was bitten by a police dog, although he was sitting on the ground with his hands raised.NPR reports that two justices, Sonia Sotomayor and Clarence Thomas, have both been skeptical of the doctrine. 763

The White House Correspondents' Association is shelving its tradition of having a comedian roast the president and the press corps at its annual fundraising dinner.Instead, the famed author Ron Chernow will "share his lively, deeply researched perspectives on American politics and history at the 2019 White House Correspondents' Dinner," the association's president Olivier Knox said.Knox made the announcement on Monday. For several months, he had been leaning against inviting a comic, and he had been conferring with other members about the change.President Trump has snubbed the event two years in a row, and there is little reason to believe that he will attend next dinner, which is scheduled for April 27, 2019.The dinner is a key date on Washington's social calendar. But its meaning has changed amid constant attacks on the media and increasing political polarization. Booking Chernow instead of a stand-up performer is a recognition that the annual dinner changes dramatically when the president isn't there.So the association had to rethink things.Historically, Knox told CNN earlier this year, "when the president comes, the program's center of gravity naturally tilts toward the president." After he speaks and ribs the press corps, the featured comedian serves as the counter-balance. But with the president absent, the dinner has a different, more combative feel.Knox and the association's board members are trying to change that."As we celebrate the importance of a free and independent news media to the health of the republic, I look forward to hearing Ron place this unusual moment in the context of American history," Knox said in a statement on Monday.Chernow is the author of six books, including best selling titles about Alexander Hamilton and George Washington. The Hamilton biography inspired Lin-Manuel Miranda's Broadway hit musical "Hamilton," and Chernow served as a historical consultant on the production.Chernow said in a statement, "The White House Correspondents' Association has asked me to make the case for the First Amendment and I am happy to oblige. Freedom of the press is always a timely subject and this seems like the perfect moment to go back to basics. My major worry these days is that we Americans will forget who we are as a people and historians should serve as our chief custodians in preserving that rich storehouse of memory. While I have never been mistaken for a stand-up comedian, I promise that my history lesson won't be dry."Comedienne Michelle Wolf spurred debate about the dinner format when she performed at last April's dinner.Some attendees loved her set, while others cringed at some parts of it.Afterward, Trump allies claimed that the jokes proved the press corps' hatred of Trump. Trump tweeted that the dinner was "embarrassing" and the event is "dead."The correspondents' association -- which did not vet her monologue ahead of time -- expressed regret that the controversy over the jokes overshadowed the dinner's First Amendment message. 3019