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SAN DIEGO (KGTV) — In the race for a coronavirus vaccine, scientists often say we need more than one winner.That’s in part because different vaccines use different strategies to provoke the immune system, and each strategy has different strengths.Take the inactivated virus vaccine, an approach currently used in the vaccine against the poliovirus. In this approach, scientists take a live virus, kill it with chemicals or heat, and then introduce that viral corpse into a person.There are three groups in the final phase of human trials using inactivated coronavirus, primarily in China, according to a tracker from the Milken Institute.“The immune system can tell the difference between something that's a real threat and something that's not a threat, and so if you get injected with a dead virus your immune system has the tendency to not pay a lot of attention to that,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.The downside of the inactivated virus approach is that it only elicits two out of the three of the parts of the immune system, Dr. Crotty said. It’s capable of producing antibodies and helper T-cells, but not killer T-cells.The modern take on the inactivated virus approach is called a viral vector vaccine.In this strategy, scientists combine elements of the coronavirus with a common cold virus called an adenovirus that won’t make you sick. Since the virus is alive, it can elicit all three kinds of immune responses, Dr. Crotty said.“There are no licensed vaccines right now that use that strategy, but there are all kinds of vaccine trials that have been done around the world with those types [of vaccines] showing that they're straightforward to manufacture. They're very safe,” he said.The University of Oxford is testing a viral vector vaccine for COVID-19 in a Phase 3 clinical trial.Then there are subunit vaccines. These include just a section -- or subunit -- of the virus’ protein.UC San Diego is working on a coronavirus candidate vaccine using this approach.There are subunit vaccines currently on the market for tetanus and other viruses.“Working with proteins is more challenging, just from a laboratory and manufacturing perspective,” Dr. Crotty said.Enter the next phase of vaccine development. Instead of using the virus itself or fragments of it, Inovio Pharmaceuticals is working on a vaccine strategy using just the virus’ genetic information.DNA-based vaccines simply introduce a genetically engineered blueprint of the virus into a person, and the cells do the rest.“Some people get confused about this. They think it’s a genetic vaccine that changes their DNA and becomes part of them, and that’s definitely not the case.” Dr. Crotty said. “They don’t become part of you. Your body chews them up.”Researchers have been working on DNA-based vaccines for about 20 years, Crotty said, but none are currently licensed for use.San Diego-based Arcturus Therapeutics is using an RNA-based approach, along with other companies like Pfizer and Moderna that have entered Phase 3 trials.Messenger RNA reads the DNA instructions and helps translate them into proteins.Dr. Crotty said the DNA and RNA approaches have similar drawbacks and benefits: they’ve never been approved for us, but both can be developed rapidly because they don’t require access to the physical virus.Around the world, there are more than 200 coronavirus vaccines currently in development, according to the Milken Institute. 3459

SAN DIEGO (KGTV) — It's Halloween week in San Diego, which means ghouls and goblins will be out to celebrate.Thursday, San Diego Zombie Crawl and and Pillage the Village hit town, giving trick-or-treaters of all ages the chance to celebrate the holiday.Día de los Muertos events also kick off this weekend, with celebrations for families to honor their families and friends in Old Town, Oceanside, Escondido, and elsewhere.Outside of the seasonal festivities, San Diego Beer Week kicks off at several breweries around the county with beer releases and specials, food pairings, and more. And the Carlsbad Village Faire promises to provide families with plenty to explore in Carlsbad, and the Fall Back Festival takes visitors back in time in the Gaslamp District.Here's a look at events to check out this weekend in San Diego:THURSDAYSan Diego Zombie Crawl Where: Gaslamp District; Cost: and upOne ticket to the San Diego Zombie Crawl grants guests access to five days of fun at more than 20 parties throughout the Gaslamp District. Day 1-3 celebrate the Halloween season with some wicked parties downtown, while the second weekend will celebrate Dia de los Muertos. Guests get the welcome shots, access to the crawl's finale party, exclusive food and drink specials.Pillage the Village and Dog-O-WeenWhere: La Jolla; Cost: FreeTake the kids out trick-or-treating in La Jolla village and frolic with all the superheroes, ghosts, and princesses during Pillage the Village. Visit merchants for a special Halloween treat and bring your pooch for a Dog-O-Ween celebration as well.FRIDAYDía de los Muertos events in San DiegoWhere: Various locations; Cost: Varies(Friday - Saturday) San Diego will hosting several Día de los Muertos events around the county this weekend. Check out celebrations that honor friends and family in Old Town, Escondido, Oceanside, and Coronado. San Diego Beer WeekWhere: Various locations; Cost: Varies(Friday - Sunday) San Diego's 10-day celebration of beer returns as San Diego Beer Week brings more than a week of special beer releases, beer gardens, drink specials, food pairings, and much more to local breweries.SATURDAYEscondido Tamale FestivalWhere: Grape Day Park; Cost: FreeEnjoy all the tamales you can handle at this celebration of the delicious dish in Escondido. Attendees will enjoy tamales from tons of food vendors, craft beers, tamale contests, a car show, live entertainment, arts and crafts, and more.Bike the CoastWhere: Oceanside; Cost: - 0Go for a ride through North County and take in pristine views of San Diego's coastal communities during Bike the Coast. The route takes riders along a 25-mile, 50-mile, or 100-mile course to a finish line festival at Oceanside Pier with music and food.Ramona Art and Wine FestWhere: Begent Ranch; Cost: - Sip on fine wines and enjoy artisan cuisine in Ramona during the Art and Wine Festival. Local artists will showcase their works and hand-painted wine barrels will be auctioned off to benefit the Ramona H.E.A.R.T. Mural Project.SUNDAYRace for the CureWhere: Balboa Park; Cost: - Lace up and help fund research and awareness for breast cancer and breast cancer survivors during the annual Susan G. Komen Race for the Cure. Runners get a special race t-shirt and can enjoy opening an closing ceremonies honoring survivors and those who we've lost to the disease.Carlsbad Fall Village FaireWhere: Carlsbad Village; Cost: FreeCheck out decor, arts and crafts, and unique gifts from more than 750 vendors during Carlsbad's massive village fair. Kids can enjoy carnival rides and games, and families will enjoy live music, delicious international foods, and a beer and wine garden.Fall Back FestivalWhere: Gaslamp District; Cost: FreeIt's time to fall back and the Gaslamp District is celebrating with a street fair featuring historical activities from way back. Kids can pan for gold, observe blacksmiths displaying their trade, or saddle up for a pony ride in the heart of San Diego. 4001

SAN DIEGO (KGTV) -- Looking to beat the heat and have some fun in the process? A North County mall has plenty of summer offerings for the whole family as temperatures rise. Westfield North County has created specific family programming throughout the week for families looking to escape the brutal North County heat. The mall is offering family game nights from 3 to 5 p.m. on Tuesday nights now through August 9. “Borrow one of our board games or play one of our life-sized versions of popular games like Tic-Tac-Toe, Jenga, Connect Four and Cornhole,” the mall says. A summer concert series will also be making its way to the mall on Fridays between 4 and 6 p.m. through the beginning of August. Check out the list of concerts below: Center Court, Level 1 July 12: The Journey Birds (Alternative Folk)July 19: Jimmy & Enrique (World Beat)July 26: The Ideas Trio (Vintage Rock & Roll)August 2: Gaby Aparicio (World Soul)August 9: Hullabaloo Band (Kids)Click here for more information on the events. 1016

SAN DIEGO (KGTV) - In the wake of the coronavirus budget crisis, cuts are being proposed to child welfare services.The proposed cuts come just weeks after Gov. Gavin Newsom announced new investments totaling million to protect younger Californians at heightened risk for abuse and mistreatment due to COVID-19.The April announcement directed funding to support families struggling to stay together, additional social worker outreach, family resources centers, and age extension for foster youth, among other things.According to the County of San Diego, "The funds approved by Governor Newsom will be used in part, as earmarked, benefiting Child Welfare families receiving emergency response and family maintenance services. The County of San Diego Health and Human Services Agency, Child Welfare Services is partnering with the state as it seeks to provide 0 monthly payments to families with children who are at risk of entering foster care. In addition, funds were allocated to help youth who have exited out of the Child Welfare System. The funds will allow foster youth who turn 21 to extend their stay in foster care to prevent potential homelessness during the COVID-19 pandemic. San Diego is receiving 0,000 in Transitional Housing Program funds from SB80 which will be used to reduce youth homelessness through the expansion of transitional housing so that we can support youth exiting foster care even after the funds provided for COVID response are no longer available. Funds are also allocated for youth to get access to cell phones and laptops through the iFoster program to continue to participate in educational activities and stay connected with their families during COVID-19. iFoster and San Diego County Child Welfare Services have been working together since 2013 to provide resources to children, youth and caregivers. CWS began working with iFoster to provide cell phones to foster youth in 2019 and will continue this partnership. "But that money will only last so long. The governor's May budget revise contains cuts to children's programs.The budget states: "Child Welfare Services include family support and maltreatment prevention services, child protective services, foster care services, and permanency programs. California's child welfare system provides a continuum of services for children who are either at risk of or have suffered, abuse, neglect, or exploitation. Program success is measured in terms of improving the safety, permanence, and well-being of children and families. The May Revision includes 6.1 million General Fund on 2020-21 for these programs, a decrease of .5 million General Fund since the Governor's Budget. When federal, state, 1991 Realignment, and 2011 Realignment funds are included, total funding for children's programs is over .7 billion in 2020-21."The proposal eliminates Foster Family Agency social worker rate increases, eliminates the Family Urgent Response System, and eliminates the Public Health Nurse Early Intervention Program in Los Angeles County."This is a time where we need to see, not cuts, but increased investment in the kinds of supports that help families meet basic needs and avoid some of the financial stresses and then receive the kinds of services and support for dealing with any issues that may trigger some abuse," said Jessica Heldman with the Children's Advocacy Institute at the University of San Diego.Heldman said they're concerned about funding to help prevent abuse and neglect, funding to foster care services, and making sure there's money to support young adults who are transitioning out of the system and have no support beyond the system.She said transitional youth leave the system at 18 or 21 and don't have a parent or legal guardian who can help with financial support or emotional support. Something as simple as a place to stay."They are high risk of some pretty poor outcomes, and it's going to take a real investment to make sure that we put them in the best position possible when they are going to be struggling," Heldman said.Heldman explained many of the youth aging out of Foster Care are losing their jobs. She cited a recent survey of about 600 transition-age foster youth across the country. It showed 65 percent of the respondents had lost their job, one in five said they are concerned about not having enough money to eat, and more than half of them had not received stimulus checks."I think people are unaware of this population of young adults and older teens who really need the support and need to be a priority or else they are going to become the parents of the next generation who are struggling economically, and the cost to that in our society is going to be far greater than the investment now to make sure that they stay on their feet," she said.Experts say a budget proposal from the Legislature released last week restores many of the cuts proposed by the governor.According to the floor report of the 2020-21 budget, “The Legislature Rejects the Governor's May Revision proposal to eliminate the Foster Family Agency social worker rate increases in 2020-21, Rejects the Governor's May Revision proposal to eliminate the Family Urgent Response System and Rejects the Governor's May Revision proposal to eliminate the Public Health Nurse Early Intervention Program in Los Angeles County among other things.”The overview of the floor report states, "The Speaker of the Assembly, the President Pro Tempore of the Senate, and the Assembly and Senate Budget Committee Chairs announced a legislative agreement on the 2020-21 state budget on June 3, 2020. This sets the stage for legislative negotiations on the budget with the Governor and his administration. The Legislature will meet the June 15 deadline to pass a balanced budget bill.""It is the responsibility of the state to ensure that children who depend on child welfare and foster care youth programs can do so confidently and without fear of abandonment, especially during these uncertain times. I have been a longtime advocate for youth, and I strongly believe that the state funding provided to these programs cannot be compromised. As budget negotiations continue, I urge the Governor's office not to balance the budget on the backs of children who need our help," Assemblymember Brian Maienschein told 10News.County of San Diego Health and Human Services representatives said the agency is monitoring the budget process, what is submitted and what the governor will sign. 6490

SAN DIEGO (KGTV) -- Mayor Kevin Faulconer Saturday detailed plans to redevelop the Sports Arena site, officially announcing what developers will tackle the project.According to Faulconer, the plan incorporates a mix of entertainment, housing, and parks."The vision for this property is for a world-class arena, park space and amenities," Faulconer said. "A new arena has always been a priority of mine, and it's the right time."Brookfield Housing and ASM Global were chosen to construct the new arena and thousands of housing units, beating out the other finalist, Toll Brothers Housing.The redevelopment area encompasses roughly 48 acres in the Midway-Pacific Highway Community area. At the press conference, representatives from the Gulls and the Seals spoke, saying they're excited for their teams to play in the new space. Faulconer said the city's goal is to include a new arena to replace Pechanga Arena."The vision for this property is for a world-class arena, park space and amenities," Faulconer said. "A new arena has always been a priority of mine, and it's the right time."The city also released several renderings of the planned development. Leaders said they are now looking toward November when Measure E will be on the ballot. This will determine if the 30-foot maximum height for buildings will remain, or if it will be raised. This will impact how tall the new facilities will be.San Diego Loyal SC, which had plans to build a modular soccer stadium at the site, commented on the announcement following the news conference. "Though the news from the city today felt like a punch in the gut, years being married to the sport of soccer has taught me that sometimes you can win on the field and not get the result that matters. I have also learned that tomorrow will come, and we will rise again,” said SD Loyal President Warren Smith. City News Service contributed to this report. 1905

来源：资阳报