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CANBERRA, Sept. 7 (Xinhua) -- A team of Australian and U.S. scientists on Wednesday said they discovered a genetic defect, which can lead to Leigh syndrome, a rare disorder which affects the central nervous syndrome.The scientists tested more than 1000 genes by encoding proteins active in two individuals who suffer from the illness. They used a new technique known as next-generation DNA sequencing to examine the genes.The gene they discovered encodes an enzyme which is found in the mitochondria which are subsets of cells. Without this enzyme the mitochondria do not translate proteins efficiently, and this then causes Leigh syndrome.According to David Thorburn, from the Murdoch Children's Research Institute in Melbourne, the discovery shows the enormous potential of the new technology."These findings demonstrate the ability of sequencing technologies to improve diagnosis," Professor Thorburn said in a statement released on Wednesday."Although it isn't clear in the case of Leigh syndrome whether the precise molecular diagnosis will necessarily lead to therapies, the current findings represent a meaningful service."He added that diagnosis of the disease along with its specific genetic cause can also be informative about the risk a couple has of having another affected child. The diagnostic information can help in decisions about whether and how to pursue alternative means of having children, for instance through the use of donor sperm or eggs.The research team consisted of scientists from Australia's Murdoch Institute as well as the Broad Institute in the U.S.In Leigh syndrome, infants are born apparently healthy only to develop movement and breathing disorders that worsen over time, often leading to death by the age of three. The problem is that the mitochondria responsible for powering their cells cannot keep up with the demand for energy in their developing brains.

SAN FRANCISCO, July 29 (Xinhua) -- Apple has ousted Nokia as the world's largest smartphone maker as global mobile phone market grew more than 11.3 percent in the second quarter of 2011, according to two separate market research studies.After becoming the largest smartphone vendor in terms of revenue and profits, Apple has become the world's largest smartphone vendor by volume with 18.5 percent market share, said the latest research from Strategy Analytics released on Friday.The Cupertino, California-based company sold 20.3 million iPhones in the second quarter,up 142 percent compared with the same period a year earlier.Samsung's shipments of 19.2 million units grew a huge 520 percent year over year, accounting for 17.5 percent global smartphone market share in the second quarter of 2011.Apple and Samsung overtook long-time volume leader Nokia for the two spots. The Finnish mobile phone giant accounted for 15.2 percent of global smartphone market share in the last quarter, which is less than half of what it was just one year earlier.In the second quarter of 2010, Nokia was the No.1 smartphone maker by volume in the world with 38.1 percent of market share. The industry is now waiting Nokia's pending transition to Windows Phone 7.According to a separate report by International Data Corporation (IDC) released on Thursday, the worldwide mobile phone market grew by 11.3 percent year over year in the second quarter of 2011 despite a decline of the feature phone market for the first time in almost two years.The feature phone market was down by 4 percent in the last quarter, said the IDC Worldwide Mobile Phone Tracker report. It noted that the decline in shipments was mainly in economically mature regions, such as the United States, Japan and Western Europe, as users making rapid transition to smartphones.The shrinking feature phone market had a great impact on some of the world's largest suppliers of mobile phones, such as Nokia, which is losing share in the feature phone category to low-cost suppliers, said the report.For the overall market, global mobile phone vendors shipped 365. 4 million units in the second quarter, compared to 328.4 million units in the same period last year, with Nokia still holding the top spot with a market share of 24.2 percent, followed by Samsung, LG Electronics, Apple and ZTE.But the 11.3 percent growth was lower than IDC's forecast for the quarter and also below the 16.8 percent growth in the first quarter of 2011.IDC said the feature phone forecast isn't expected to be any rosier in the future and the shipment growth of feature phones won 't exceed 1.1 percent in the coming years.

BUDAPEST, June 25 (Xinhua) -- Visiting Chinese Premier Wen Jiabao made a five-point proposal here Saturday to enhance China's cooperation with countries in Central and Eastern Europe.When delivering a speech at the China-Central and East European Countries Economic and Trade Forum, Wen said China cherished its longstanding and deep friendship with the countries in the region."Over the past several decades, although the international situation and the domestic situations of both sides have undergone big changes, we have always enjoyed mutual respect, mutual trust, mutual understanding and mutual support," Wen said. Chinese Premier Wen Jiabao addresses the China-Central and Eastern European Countries Economic and Trade Forum in Budapest, Hungary, June 25, 2011.He said cooperation in various fields between the two sides had made tremendous progress, referring to the rapid growth of two-way trade, the burgeoning of mutual investment, the expansion of cooperation areas and the improvement of cooperation mechanisms.China encouraged its companies to "go global" and saw Central and Eastern Europe as a strategic priority, the Chinese leader said, adding that his current visit was "both a journey of friendship and a journey of cooperation."

BEIJING, Aug. 13 (Xinhua) -- Chinese rating agency Dagong Global Credit Rating Co. on Saturday defended its AAA rating given to the Ministry of Railways, which has been under public fire over a train collision last month.The ministry received the long-term credit rating after launching on Monday its first bond sales since the crash on July 23 that killed 40 people near the Wenzhou city of eastern Zhejiang province.It sold 20 billion yuan worth of three-month bills on offer in the interbank market, with a yield of 5.55 percent, a relatively high rate for short-term government paper.The rating was assigned because of the ministry's status as a government agency backed by the central government revenue, its sufficient capital flows and strong financing ability, Dagong said in an email to Xinhua.The agency made the elaboration in response to market doubts as the ministry is already heavily indebted and the accident has stirred up skepticism about the its credibility and the safety of fast-expanding railways.Adding to doubts is that the AAA rating of the ministry is even a notch above China's local currency debt rating of AA+, which was also rated by Dagong.Government data showed the ministry's debts exceeded 2 trillion yuan (313 billion U.S. dollars) as of the end of June, raising its debt ratio to 58.53 percent, slightly up from the end of the first quarter of this year.Dagong said in the statement that the debt-to-asset ratio is medium level, lower than the alert line for the ministry which is 75 percent.The ministry has large-scale assets of good quality and relatively large room for fund-raising, Dagong said.The ministry has "extremely strong" repayment ability as it is backed by the state's credit, Dagong said, referring it as one of the three authorities that are allowed to issue bonds, along with the Ministry of Finance and the People's Bank of China.In July, the ministry issued 20 billion yuan of one-year commercial papers with a coupon rate of 5.18 percent, but only 18.73 billion yuan of the total was bought.Analysts said it has become more difficult for the ministry to borrow money because of tightened market liquidity and concerns over the ministry's debt burden.China's top four banks said at the end of last month that they will continue to offer loans to the ministry based on market conditions and risk appraisal. Credit from the four largest state-owned banks including the Industrial and Commercial Bank of China and the Construction Bank of China has been the major source funding the construction of China's fast-growing railways in recent years.

SAN FRANCISCO, July 20 (Xinhua) -- Google announced on Wednesday that it has reached a deal with author J.K. Rowling to launch the series of Harry Potter ebooks on Google's platform.When the series of Harry Potter ebooks launch on Pottermore.com in early October, the bestsellers will be available in the United States via Google eBooks platform, said Google in a blog post.When customers buy a Harry Potter ebook from Pottermore.com, they will be able to choose to keep it in their Google's online library in the cloud, as well as other e-reading platforms.Google said Google eBooks can be read on most devices with a modern browser, through Google apps for iOS and Android smartphones and tablets, and on more than 80 e-readers.Meanwhile, Rowling will continue to issue announcements via YouTube, as she announced Pottermore.com in June.The two sides also agreed to make Google Checkout the preferred third-party payment platform for all purchases made on Rowling's Pottermore.com.Pottermore.com, which will be launched on July 31, will sell ebook and audiobook versions of the seven Harry Potter novels, as well as additional content including background details and settings.According to The Times, the Harry Potter brand value is estimated to be more than 15 billion U.S. dollars. The deal could make Google move some e-reader customers from competitors like Amazon, whose e-reader Kindle does not support Google eBooks.

来源：资阳报