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Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

Carrie Underwood recently shared a photo of herself on social media rehearsing to gear up for her performance at the Academy of Country Music Awards.This will be her first performance since her nasty fall on the steps of her Nashville home in November. Underwood will be belting out her brand new single "Cry Pretty" released on April 11th.The return to the stage will be a big moment for one of the genre's leading female voices. She has stayed out of the public eye during much of her recovery. She told fans late last year that she required 40-50 stitches after the injury. Underwood is nominated for two ACM's this year: Female Vocalist of the Year and Vocal Event of the Year for her contributions to Keith Urban's "The Fighter".The ACMs air Sunday night live from Las Vegas at 7 p.m. CT.  817

CHICAGO, Ill. -- The IRS says it has issued more than 159 million stimulus payments in just over two months. About 0 billion has been dispersed via direct deposit, paper check and pre-paid debit cards. Yet, even today there are countless eligible Americans who say they’ve fallen through the cracks.In New York state, Hanna Brandow has no idea why she hasn’t gotten a stimulus payment.“My sister and I who both have not gotten the check yet. We did our taxes this year and got our returns already,” said Brandow. “So, it's very strange.”In California, Alexis Lopez is also in limbo.“For most people, it was like 'this person got it, this person got it,' said Lopez. "I was like, ‘well maybe there's some delay with mine.’ No big deal.”And in Ohio, Karen Melroy is also stuck in in stimulus purgatory.“I received my refund by a direct deposit,” said Melroy. “So, there's no reason I can think of why I shouldn't have received one.”All of them say they get the same message when checking on the IRS website.“I normally add a few more expletives to mine when I see it, but it's something to the effect of payment status not available,” said Melroy.It turns out they’re not alone. Those four words: "payment status not available" are exasperating countless Americans who appear otherwise eligible for payments but have not been paid and can’t get answers as to why.“The IRS obviously was very rushed and even when the government takes a year and a half to do a computer system, there are problems with it,” said Robert Probasco, director of the tax clinic at Texas A&M University.In May the IRS added 3,500 telephone representatives to help with problems, but most can only provide general information.“I found this like nine-step guide of how to get a human on the phone at the IRS. I did it twice and hit a dead end,” said Brandow.Because IRS offices remain closed due to the pandemic, the agency tells us that call center agents are working from home. That means they don’t have access to secure personal information specific to each case.“This was designed poorly obviously because it doesn't tell you which of those things happen and if it is a glitch, it doesn't tell you what kind of a glitch,” said Probasco.The IRS is doing a phased reopening at key processing sites and call centers.The IRS tells us some employees have returned to work in Kentucky, Texas and Utah. They say they will follow state and local guidelines as employees return to work in Georgia, Tennessee, Missouri, Michigan and by the end of June in Indiana, Ohio, California, Oregon and Puerto RicoBut if you can’t get your payment issue resolved by the end of the year, you may have to claim your unpaid stimulus assistance on next year’s tax return as a credit.“That doesn't help me today,” said Melroy.That's a sentiment many like Alexis Lopez share as they struggle to rebound financially from the pandemic.“You're left in limbo wondering, 'am I ever going to get this stimulus check that most Americans received?' And I'm in the minority that has not and there's no answers,” she said.The agency says for case-specific information ,the appropriate number to call remains 800-829-1040. Otherwise, you could call your local IRS office and even set up a face-to-face meeting once they reopen. 3281

CARLSBAD, Calif. (KGTV) -- Carlsbad Police announced Monday that a suspect has been arrested in the murder of Lisa Thorborg, the woman stabbed to death on a North County trail.According to police, Thorborg was found fatally stabbed on the Hosp Grove Trail in late November.The body was found by a passerby who called police.RELATED STORIESCarlsbad neighbors honor murdered woman by finishing her hikeWoman stabbed to death on Carlsbad trail identifiedCarlsbad police: Woman found dead on hiking trail was stabbed to deathAccording to police, a 17-year-old male who lives in Carlsbad was arrested. The name hasn’t been released at this time.“We understand that the community has been on edge since that tragic day in November when Lisa was found on Hosp Grove Trail,” stated Investigations Lieutenant Jason Jackowski. “Our unwavering mission has been to find the suspect for Lisa, her family and the community of Carlsbad.” 930

CHICAGO (AP) — President-elect Joe Biden is considering former Chicago Mayor Rahm Emanuel to serve as his transportation secretary.Biden's pick to lead the Transportation Department is not believed to be imminent, and Emanuel is among multiple candidates in the running for the Cabinet position. That's according to people familiar with the matter who spoke on the condition of anonymity to discuss the private deliberations.During his 8-year tenure as mayor, Emanuel is credited with fixing Chicago’s ragged public transportation system, overhauling O'Hare International Airport and Midway International Airport, and making the city a bicycle-friendly city, the Associated Press reported.Biden and Emanuel are no strangers to each other. Before becoming mayor of Chicago, Emanuel served as former President Barack Obama's first White House chief of staff.Emanuel is a substantial and somewhat divisive figure in Democratic Party politics.Some party progressives are critical of Emanuel's handling of the 2018 police shooting death of Black teenager Laquan McDonald by a white officer when Emanuel was mayor. 1116