成都静脉血栓治疗需要多钱(成都医院能做血管炎微创手术) (今日更新中)

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) -- Chula Vista City Councilman Steve Padilla remains hospitalized on a ventilator but is now in stable condition, according to a family statement issued Wednesday. Padilla, who represents Chula Vista's District 3, was admitted at UCSD Thornton Hospital ICU last Thursday after experiencing difficulty breathing associated with COVID-19. The family said he required a respirator.“My dad is a fighter, and he’s fighting through this -- with the help of amazing doctors, nurses and healthcare workers who are caring for him," said the councilman's daughter Ashleigh Padilla in a statement Wednesday night."We’re hopeful that he’s reached a turning point and will be home soon," she said.No further details about his condition were given at this time.“I know he cannot wait to get back to serving the people and helping our entire community get through these tough times," his daughter said.Padilla told his constituents in a Facebook video post published March 14 that he had contracted the coronavirus. He appeared to be in good spirits as he told viewers that he was doing "very well" and "feeling well.""After recently experiencing symptoms, I was diagnosed as being positive for the COVID-19 virus, also known as the coronavirus," he said last Saturday.In a follow up statement that night, Padilla described having a fever, body aches, headaches, chills, that "came on very rapidly." He noted he had come into contact with friends, colleagues, and the public over the last week."I’m in close coordination with County Public Health officials who are taking all precautions to ensure the health of people I’ve been in contact with," he said.Padilla issued a warning to the public through his daughter last Thursday: “Everyone needs to take COVID-19 seriously. Please follow the advice of our public health professionals to reduce spread of the virus and take precautions to keep your families and our community safe," said Ashleigh Padilla.Padilla previously served as Mayor of Chula Vista from 2002-2006, and is a former officer and detective with the Chula Vista Police Department.On the Chula Vista city website, Padilla is noted for being the first person of color ever elected to City office in Chula Vista history, the first Latino Mayor, and the first openly LGBT person to serve or be elected to city office. 2342

SAN DIEGO (KGTV) - Approximately 900,000 San Diegans who pay for sewer services may have had their rights violated.It’s part of what being alleged in a massive new class action lawsuit against the City of San Diego, its Public Utilities Department and the San Diego City Council.The suit calls it an “illegal financing scheme”. Attorneys who brought the suit claim the issue surrounds the city’s million smart water meter system and how it was paid for.  The lawsuit alleges the city knowingly used about million from the city's sewer fund instead of the city's water fund to help pay for that meter system.Subsequently, hundreds of thousands of San Diego sewer ratepayers were allegedly misinformed about what their money was being used for. Attorneys argue sewer ratepayers were quite possibly paying for a system that they did not necessarily benefit from- the smart water meter system. It’s still unknown whether there were any rate hikes directly tied to this.The suit claims the situation was an unconstitutional grab of million in funds.The San Diego City Attorney’s Office is reviewing the complaint and will respond through the court. 1183

SAN DIEGO (KGTV) — As wildfires continue to burn in California, researchers say they may be adding fuel to another emergency: the pandemic.Parts of the Golden State have been buried in a blanket of smoke for weeks. Wildfire smoke is a mixture of many pollutants, but the majority consists of tiny particulate matter called PM2.5, which can also be produced by cars and power plants.“It’s a threat amplifier,” said Dr. Abisola Olulade of Sharp Rees-Stealy Medical Group.In April, researchers at Harvard found that just a small increase in this kind of air pollution led to an 8% jump in the death rate from COVID-19.Studies have shown that air pollution from these tiny particles can increase the risk of death in older adults from other causes, but the Harvard researchers found the increase from COVID-19 was 20 times larger.Why? The most widely accepted theory is that smoke particles, which can burrow deep inside the lungs and enter the bloodstream, can add a layer of health complications for people already fighting the virus.“People that are already fighting off a COVID-19 infection already have compromised heart and lung function if they have severe illness,” Dr. Olulade said. “So that can increase their susceptibility to the effects of wildfires.”The particles can contribute to more inflammation and potentially lead to blood clotting, she said.“Any chink in the armor, so to speak, is going to really make people have trouble maintaining” the body’s stressful fight against the virus, said Dr. Christian Ramers of Family Health Centers of San Diego.Another theory from early COVID-19 research that hasn’t been peer-reviewed: smoke particles could allow the virus to travel farther and survive longer, potentially allowing it to spread to more people. Both Dr. Ramers and Dr. Olulade said there was less research to support this theory.“What makes the sky look hazy when there’s smoke? It’s particles. So it's conceivable, again this is kind of conjecture, but it's conceivable with more particles in the air then yes the virus can latch onto those particles a bit more,” said Dr. Ramers.Doctors say there’s stronger evidence to suggest that wildfire smoke could help the virus enter a healthy person’s body. Not only does smoke wear down the protective lining of our airways, it stimulates certain receptors in the lungs -- the exact receptors that the spike proteins of the coronavirus use to get inside cells.“The virus binds to those ACE2 receptors, so if you have more of them, it can increase the viral load,” said Dr. Olulade.All kinds of air pollution put us at greater risk from respiratory diseases like coronavirus, not just wildfires. But one thing is for sure: Californians have been exposed to a lot of smoke lately.Since the beginning of the year, wildfires in California have burned more than 3 million acres, according to CAL Fire. That’s an area larger than the entire County of San Diego. 2929

SAN DIEGO (KGTV) - Another testing site is being added to San Diego County, and this one will be the closest to the U.S.-Mexico border so far for the region.The San Ysidro port of Entry’s PedWest crossing is one of the world’s busiest pedestrian international border crossings. Within the next two weeks, a testing site at that location will join the more than two dozen others across San Diego County. It will be an appointment-free, walk-up site. Officials expect 200 tests to be done daily there.Chicano Federation Chief Strategy Officer Roberto Alcantar said this is a step in the right direction as far as testing is concerned, but said there is still work to be done to help the Latino community.Related: San Diego County launches COVID-19 outreach campaign for LatinosHe said many in the Latino community are afraid of getting tests done because of the fear of a positive test.“Our community is nervous about losing their jobs, not being able to go to work, the real economic impact that comes from being positive and feeling that that might hinder them in a way,” he said.He added that this is a big-picture problem. The Latino community lacks affordable housing, forcing families to live in close quarters and increasing the risk of spreading the virus, and also forcing people to live across the border to find affordable housing. Many of these people are essential workers and need to continue to work to support their families, so they cross the border on a daily basis. This new site will help give them access to testing.“They’re having to cross the border every day. We’re hearing from workers that they’re spending 4-5 hours every day waiting just to cross,” said Alcantar.Alcantar also said that the new testing site will likely lead to more positive rates, as is expected with increased testing, and he worries about what that will do to the perception of the Latino community, which already has higher numbers than the rest. As of August 9, 62% of San Diego’s cases are Hispanic people, a community that makes up just 34% of the population. That number will likely continue to climb with another testing site in an area dominated by Spanish speakers. This, tied with a perception that people are carrying the virus from Mexico to the U.S., could be bad.“Our concern is that this will help push further that narrative that we have to have a testing site because the rates are coming from Mexico,” he said.The Chicano Federation has been working with UCSD to reach out to the Latino community and find out why they don’t want to get tested and also encourage them to get tested. They also have been working with the county and giving feedback on testing in the Latino community.San Diego County also launched a campaign at the end of July targeted at helping get resources and information to the Latino community about safety measures, testing resources and contact tracing. 2899

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